The nucleotide analog 2-aminopurine as a spectroscopic probe of nucleotide incorporation by the Klenow fragment of Escherichia coli polymerase I and bacteriophage T4 DNA polymerase

FIDELITY MECHANISMS IN DNA REPLICATION

1991 • 709 citations

Fluorescence Studies of Nucleotides and Polynucleotides

1969 • 589 citations

CONFORMATIONAL COUPLING IN DNA POLYMERASE FIDELITY

1993 • 558 citations

Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant

1991 • 495 citations

EUKARYOTIC DNA POLYMERASES

1991 • 493 citations

An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics

1991 • 364 citations

Kinetic mechanism of DNA polymerase I (Klenow)

1987 • 352 citations

Genetic and Crystallographic Studies of the 3′,5′-Exonucleolytic Site of DNA Polymerase I

1988 • 344 citations

Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity

1988 • 278 citations

Kinetic mechanism of DNA polymerase I(Klenow fragment): identification of a second conformational change and evaluation of the internal equilibrium constant

1991 • 218 citations

Deoxyribonucleic Acid Polymerase: Two Distinct Enzymes in One Polypeptide

1972 • 215 citations

Kinetic partitioning between the exonuclease and polymerase sites in DNA error correction

1991 • 208 citations

Kinetic characterization of the polymerase and exonuclease activities of the gene 43 protein of bacteriophage T4

1992 • 207 citations

Dynamics of mismatched base pairs in DNA

1991 • 203 citations

Base pairing and mutagenesis: observation of a protonated base pair between 2-aminopurine and cytosine in an oligonucleotide by proton NMR.

1986 • 202 citations

Elementary steps in the DNA polymerase I reaction pathway

1983 • 179 citations

Purine studies. Part I. Stability to acid and alkali. Solubility. Ionization. Comparison with pteridines

1954 • 173 citations

[61] Rapid kinetic analysis of mechanochemical adenosinetriphosphatases

1986 • 151 citations

Comparison of nucleotide interactions in water, proteins, and vacuum: model for DNA polymerase fidelity.

1986 • 148 citations

Rate-limiting steps in the DNA polymerase I reaction pathway

1985 • 133 citations

The steady state kinetic parameters and non-processivity of Escherichia coli deoxyribonucleic acid polymerase I

1975 • 120 citations

A fluorescence-based assay for monitoring helicase activity.

1994 • 118 citations

Construction and characterization of a bacteriophage T4 DNA polymerase deficient in 3'-->5' exonuclease activity.

1993 • 109 citations

Pre-Steady-State Kinetic Analysis of Sequence-Dependent Nucleotide Excision by the 3'-Exonuclease Activity of Bacteriophage T4 DNA Polymerase

1994 • 99 citations

Structure and function of the bacteriophage T4 DNA polymerase holoenzyme

1992 • 96 citations

DNA polymerase III holoenzyme. Components, structure, and mechanism of a true replicative complex.

1991 • 90 citations

Influence of 5'-nearest neighbors on the insertion kinetics of the fluorescent nucleotide analog 2-aminopurine by Klenow fragment

1993 • 86 citations

Mechanism of DNA replication fidelity for three mutants of DNA polymerase I: Klenow fragment KF(exo+), KF(polA5), and KF(exo-)

1991 • 81 citations

The minimal kinetic mechanism for misincorporation by DNA polymerase I (Klenow fragment)

1992 • 76 citations

Mechanism of DNA polymerase I: exonuclease/polymerase activity switch and DNA sequence dependence of pyrophosphorolysis and misincorporation reactions.

1986 • 55 citations

Mechanistic aspects of DNA polymerases: Escherichia coli DNA polymerase I (Klenow fragment) as a paradigm

1990 • 49 citations

On the processive mechanism of Escherichia coli DNA polymerase I. Delayed initiation of polymerization.

1976 • 28 citations

Mechanism of the idling-turnover reaction of the large (Klenow) fragment of Escherichia coli DNA polymerase I.

1986 • 22 citations