Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors
Data up to Jan 2025
Total Citations Per Year
Abstract
References (54)
Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.
1995 • 2,534 citations
CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors
1997 • 2,201 citations
The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1
1995 • 2,199 citations
Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin‐Dependent Kinases cdc2, cdk2 and cdk5
1997 • 1,324 citations
Tau in Alzheimer's disease
1998 • 936 citations
GROWTH AND DIFFERENTIATION IN TRYPANOSOMA CRUZI. I. ORIGIN OF METACYCLIC TRYPANOSOMES IN LIQUID MEDIA.
1964 • 908 citations
Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors
1998 • 792 citations
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases
1999 • 784 citations
Genetic Analysis of the Human Malaria Parasite Plasmodium falciparum
1987 • 719 citations
Inhibition of Cyclin‐Dependent Kinases by Purine Analogues
1997 • 680 citations
Inhibition of Cyclin‐Dependent Kinases by Purine Analogues
1994 • 625 citations
P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro
1997 • 539 citations
Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent
2000 • 419 citations
Structural basis of inhibitor selectivity in MAP kinases
1998 • 408 citations
Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.
1998 • 408 citations
Potent Inhibition of Cdc2 Kinase Activity by the Flavonoid L86-8275
1994 • 349 citations
Paullones, a Series of Cyclin-Dependent Kinase Inhibitors: Synthesis, Evaluation of CDK1/Cyclin B Inhibition, and in Vitro Antitumor Activity
1999 • 314 citations
Multiple modes of ligand recognition: Crystal structures of cyclin‐dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine
1995 • 273 citations
Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors
1999 • 267 citations
ATP-site Directed Inhibitors of Cyclin-dependent Kinases
1999 • 256 citations
Chemical inhibitors of cyclin-dependent kinases
1996 • 251 citations
Progress in Cell Cycle Research
1997 • 243 citations
Physiology and pathology of tau protein kinases in relation to Alzheimer's disease.
1997 • 232 citations
Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase.
1993 • 225 citations
Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases.
1999 • 219 citations
High-Resolution Crystal Structures of Human Cyclin-Dependent Kinase 2 with and without ATP: Bound Waters and Natural Ligand as Guides for Inhibitor Design
1996 • 197 citations
Requirement for Cellular Cyclin-Dependent Kinases in Herpes Simplex Virus Replication and Transcription
1998 • 159 citations
Cyclin B targets p34cdc2 for tyrosine phosphorylation.
1991 • 152 citations
CDK inhibition and cancer therapy
1999 • 149 citations
Inhibition of Cellular Cdk2 Activity Blocks Human Cytomegalovirus Replication
1997 • 143 citations
Chemical inhibitors of cyclin-dependent kinases
1997 • 138 citations
CVT-313, a Specific and Potent Inhibitor of CDK2 That Prevents Neointimal Proliferation
1997 • 138 citations
Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist.
1997 • 136 citations
Sequential Dephosphorylation of p34 on Thr-14 and Tyr-15 at the Prophase/Metaphase Transition
1996 • 136 citations
6-Dimethylaminopurine blocks starfish oocyte maturation by inhibiting a relevant protein kinase activity
1988 • 133 citations
Cyclic activation of histone H1 kinase during sea urchin egg mitotic divisions
1988 • 126 citations
A Structure-Based Library Approach to Kinase Inhibitors
1996 • 125 citations
Prevention of graft coronary arteriosclerosis by antisense cdk2 kinase oligonucleotide
1997 • 115 citations
Cell-cycle control and renal disease
1997 • 97 citations
The molecular basis of cell cycle and growth control
1999 • 95 citations
Plasmodium falciparum: Modifications of the In vitro Culture Conditions Improving Parasitic Yields
1982 • 91 citations
Properties and Potential Applications of Chemical Inhibitors of Cyclin-Dependent Kinases
1999 • 88 citations
Combinatorial synthesis of 2,9-substituted purines
1997 • 86 citations
Facile Preparation of 2,6-Disubstituted Purines Using Solid-Phase Chemistry
1997 • 78 citations
A new screening test for antimitotic compounds using the universal M phase-specific protein kinase, p34cdc2/cyclin Bcdc13, affinity-immobilized on p13suc1-coated microtitration plates.
1991 • 66 citations
A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: Biochemical identification using Xenopus egg extracts
1999 • 65 citations
The cell cycle in protozoan parasites
2000 • 55 citations
Identification, Cloning, and Mutational Analysis of the Casein Kinase 1 cDNA of the Malaria Parasite, Plasmodium falciparum
1997 • 50 citations
Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases
1998 • 49 citations
Varicella-Zoster Virus Fc Receptor Component gI Is Phosphorylated on Its Endodomain by a Cyclin-Dependent Kinase
1999 • 46 citations
Cyclin Dependent Kinase (CDK) Inhibitors
1998 • 33 citations
Cyclin-Dependent Kinase Inhibitors of Saccharomyces cerevisiae and Schizosaccharomyces pombe
1998 • 24 citations
Starfish oocyte maturation: from prophase to metaphase
1994 • 20 citations
Cell cycle control
1997 • 3 citations
Cited By (0)
No citing papers found in database