Multiple modes of ligand recognition: Crystal structures of cyclin‐dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Analytical molecular surface calculation

1983 • 2,454 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

Improved Fourier coefficients for maps using phases from partial structures with errors

1986 • 1,897 citations

A graphics model building and refinement system for macromolecules

1978 • 1,858 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1994 • 982 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

A family of human cdc2-related protein kinases.

1992 • 928 citations

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1992 • 906 citations

The structure of protein-protein recognition sites.

1990 • 825 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

Amino‐aromatic interactions in proteins

1986 • 752 citations

Cyclins and cancer

1991 • 701 citations

Aromatic rings act as hydrogen bond acceptors

1988 • 685 citations

Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.

1992 • 638 citations

Inhibition of Cyclin‐Dependent Kinases by Purine Analogues

1994 • 625 citations

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with magnesium-ATP and peptide inhibitor

1993 • 593 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

Slow-cooling protocols for crystallographic refinement by simulated annealing

1990 • 530 citations

Redundant cyclin overexpression and gene amplification in breast cancer cells.

1993 • 526 citations

Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.

1991 • 502 citations

Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15.

1993 • 475 citations

Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.

1991 • 459 citations

Role of phosphorylation in p34cdc2 activation: identification of an activating kinase.

1992 • 459 citations

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

1993 • 399 citations

Structure of myohemerythrin in the azidomet state at resolution

1987 • 377 citations

2.2 Å refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor

1993 • 356 citations

Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.

1991 • 318 citations

A cell cycle-regulated inhibitor of cyclin-dependent kinases.

1994 • 285 citations

Crystal structures of the myristylated catalytic subunit of cAMP‐dependent protein kinase reveal open and closed conformations

1993 • 284 citations

Antibody-antigen interactions

1993 • 282 citations

p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.

1992 • 276 citations

Activation of human cyclin-dependent kinases in vitro.

1992 • 242 citations

Targets of cyclin-dependent protein kinases

1993 • 240 citations

A comparison of the heme binding pocket in globins and cytochrome b5.

1975 • 237 citations

Stereochemical Criteria for Polypeptide and Protein Chain Conformations

1966 • 183 citations

Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitro.

1993 • 161 citations

Mycorrhizal fungi stimulate clover growth in New Zealand hill country soils

1976 • 79 citations

Adenosine cyclic 3',5'-monophosphate dependent protein kinase: a new fluorescence displacement titration technique for characterizing the nucleotide binding site on the catalytic subunit

1983 • 75 citations

Mapping the ATP-Binding Site in the Catalytic Subunit of A denosine-3':5'-monophosphate-Dependent Protein Kinase. Spatial Relationship with the ATP Site of the Undissociated Enzyme

1978 • 64 citations

Purification and Crystallization of Human Cyclin-dependent Kinase 2

1993 • 64 citations

PAP: a protein analysis package

1990 • 9 citations