Superantigens —remnants of a past process?

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

The Staphylococcal Enterotoxins and Their Relatives

1990 • 1,914 citations

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

1988 • 1,161 citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

1989 • 1,095 citations

The somatic generation of immune recognition

1971 • 974 citations

The outline structure of the T-cell alpha beta receptor.

1988 • 625 citations

Superantigens interact with MHC class II molecules outside of the antigen groove

1990 • 438 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR

1989 • 388 citations

Crystal structure of staphylococcal enterotoxin B, a superantigen

1992 • 304 citations

Molecular Components of T-Cell Recognition

1992 • 304 citations

Residues of the variable region of the T-cell-receptor β-chain that interact with S. aureus toxin superantigens

1990 • 301 citations

Expression of T-cell antigen receptor genes during fetal development in the thymus

1985 • 293 citations

Class II MHC Molecules Are Specific Receptors for Staphylococcus Enterotoxin A

1989 • 267 citations

HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells.

1990 • 253 citations

Identification of the region of T cell receptor β chain that interacts with the self-superantigen MIs-1a

1990 • 242 citations

Mutations defining functional regions of the superantigen staphylococcal enterotoxin B.

1992 • 208 citations

Implications of a Fab-like structure for the T-cell receptor

1989 • 193 citations

Binding of staphylococcal enterotoxin A to HLA-DR on B cell lines.

1989 • 169 citations

Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules.

1989 • 139 citations

Two adjacent residues in staphylococcal enterotoxins A and E determine T cell receptor V beta specificity.

1993 • 122 citations

Zinc regulates the function of two superantigens.

1992 • 122 citations

Identification of the staphylococcal enterotoxin A superantigen binding site in the beta 1 domain of the human histocompatibility antigen HLA-DR.

1991 • 119 citations

Identification of HLA-DR1 beta chain residues critical for binding staphylococcal enterotoxins A and E.

1992 • 116 citations

Staphylococcal enterotoxin B and toxic shock syndrome toxin-1 bind to distinct sites on HLA-DR and HLA-DQ molecules.

1989 • 105 citations

Direct binding of secreted T-cell receptor beta chain to superantigen associated with class II major histocompatibility complex protein.

1991 • 87 citations

Enterotoxin residues determining T-cell receptor Vβ binding specificity

1992 • 77 citations

Resolution of hypervariable regions in T-cell receptor beta chains by a modified Wu-Kabat index of amino acid diversity.

1990 • 62 citations

Identification of HLA-DR alpha chain residues critical for binding of the toxic shock syndrome toxin superantigen.

1992 • 56 citations

T-cell antigen receptor binding sites for the microbial superantigen staphylococcal enterotoxin A.

1992 • 40 citations

Structural basis for differential binding of staphylococcal enterotoxin A and toxic shock syndrome toxin 1 to class II major histocompatibility molecules.

1991 • 39 citations

AN EXTERNAL STIMULUS THAT MIMICS Mls LOCUS RESPONSES

1988 • 34 citations

The I-Aβb region (65–85) is a binding site for the superantigen, staphylococcal enterotoxin A

1990 • 29 citations

Sequences in both class II major histocompatibility complex alpha and beta chains contribute to the binding of the superantigen toxic shock syndrome toxin 1.

1992 • 29 citations

Both alpha-helices along the major histocompatibility complex binding cleft are required for staphylococcal enterotoxin A function.

1991 • 28 citations

Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules

1989 • 13 citations

Antigen processing and presentation

1990 • 7 citations