Superantigens interact with MHC class II molecules outside of the antigen groove

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

Empirical Predictions of Protein Conformation

1978 • 3,167 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

1988 • 1,161 citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

1989 • 1,095 citations

Principles of Protein Structure

1979 • 1,090 citations

Vβ-Specific Stimulation of Human T Cells by Staphylococcal Toxins

1989 • 711 citations

Specificity pockets for the side chains of peptide antigens in HLA-Aw68

1989 • 664 citations

T cell stimulation by staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells.

1988 • 427 citations

High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR

1989 • 388 citations

The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells.

1990 • 347 citations

T‐Cell Responses to Mls and to Bacterial Proteins that Mimic its Behavior^#

1989 • 337 citations

Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope

1987 • 297 citations

The murine T-cell receptor uses a limited repertoire of expressed Vβ gene segments

1985 • 283 citations

Class II MHC Molecules Are Specific Receptors for Staphylococcus Enterotoxin A

1989 • 267 citations

Antigenic competition at the level of peptide-Ia binding.

1986 • 216 citations

Compartmentalization of MHC class II gene expression in transgenic mice

1988 • 201 citations

Binding of staphylococcal enterotoxin A to accessory cells is a requirement for its ability to activate human T cells.

1988 • 187 citations

Binding of staphylococcal enterotoxin A to HLA-DR on B cell lines.

1989 • 169 citations

Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules.

1989 • 139 citations

Antigen processing at the molecular level

1987 • 137 citations

Bacterial proteins that mediate the association of a defined subset of T cell receptor:CD4 complexes with class II MHC.

1990 • 130 citations

The T cell repertoire may be biased in favor of MHC recognition

1986 • 121 citations

An immunodominant class I-restricted cytotoxic T lymphocyte determinant of human immunodeficiency virus type 1 induces CD4 class II-restricted help for itself.

1990 • 110 citations

Oligonucleotide-directed mutagenesis by microscale ‘shot-gun’ gene synthesis

1985 • 105 citations

Specificity of the T cell receptor: two different determinants are generated by the same peptide and the I-Ak molecule.

1985 • 98 citations

Mutations of class II MHC molecules

1987 • 85 citations

Direct evidence that a class II molecule and a simple globular protein generate multiple determinants.

1985 • 84 citations

The assignment of chain specificities for anti-Ia monoclonal antibodies using L cell transfectants.

1986 • 83 citations

Identical Vβ T-cell receptor genes used in alloreactive cytotoxic and antigen plus I–A specific helper T cells

1985 • 79 citations

Identical peptides recognized by MHC class I- and II-restricted T cells.

1989 • 63 citations

Comparison of the secondary structures of human class I and class II major histocompatibility complex antigens by Fourier transform infrared and circular dichroism spectroscopy.

1989 • 61 citations

Predominant role of amino-terminal sequences in dictating efficiency of class II major histocompatibility complex alpha beta dimer expression.

1987 • 57 citations

T cell receptor gene segment usage in a panel of hen-egg white lysozyme specific, I-Ak-restricted T helper hybridomas.

1989 • 48 citations

T cell recognition of bovine ribonuclease. Self/non-self discrimination at the level of binding to the I-Ak molecule.

1988 • 47 citations

Bacterial toxins as probes for the T-cell antigen receptor

1989 • 45 citations

A molecular basis for the Ia.2 and Ia.19 antigenic determinants.

1985 • 40 citations

Identification of an immunodominant region on the I-A beta chain using site-directed mutagenesis and DNA-mediated gene transfer.

1988 • 39 citations

AN EXTERNAL STIMULUS THAT MIMICS Mls LOCUS RESPONSES

1988 • 34 citations

I-A alpha polymorphic residues that determine alloreactive T cell recognition.

1989 • 30 citations

Enhanced immunogenicity of a T cell immunogenic peptide by modifications of its N and C termini

1989 • 29 citations

Reconstruction of the immunogenic peptide RNase(43-56) by identification and transfer of the critical residues into an unrelated peptide backbone.

1989 • 29 citations

Functional sites on la molecules: A molecular dissection of Aα immunogenicity

1986 • 26 citations

Fine specificity of murine class II-restricted T cell clones for synthetic peptides of influenza virus hemagglutinin. Heterogeneity of antigen interaction with the T cell and the Ia molecule.

1988 • 24 citations

MHC class II A alpha and E alpha molecules determine the clonal deletion of V beta 6+ T cells. Studies with recombinant and transgenic mice.

1989 • 24 citations

A beta polymorphic residues responsible for class II molecule recognition by alloreactive T cells.

1989 • 22 citations

Regulation of murine MHC class II molecule expression. Identification of A beta residues responsible for allele-specific cell surface expression.

1988 • 21 citations

Polymorphic residues on the I-A beta chain modulate the stimulation of T cell clones specific for the N-terminal peptide of the autoantigen myelin basic protein.

1989 • 18 citations

Epitopic analysis by anti-I-Ak monoclonal antibodies of I-Ak-restricted presentation of lysozyme peptides.

1989 • 16 citations

I-Ak polymorphisms define a functionally dominant region for the presentation of hen egg lysozyme peptides

1989 • 15 citations

Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules

1989 • 13 citations

Antigen presentation to specific T cells by la molecules selectively altered by site-directed mutagenesis

1989 • 11 citations

Slot-machine mutagenesis of a polymorphic residue on the A kappa alpha-chain.

1988 • 9 citations

Functional sites on the A alpha-chain. Polymorphic residues involved in antigen presentation to insulin-specific, Ab alpha:Ak beta-restricted T cells.

1989 • 8 citations