Human monocytes are stimulated for nitric oxide release in vitro by some tumor cells but not by cytokines and lipopolysaccharide

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide.

1993 • 623 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Phenotype of the accessory cell necessary for mitogen-stimulated T and B cell responses in human peripheral blood: delineation by its sensitivity to the lysosomotropic agent, L-leucine methyl ester.

1983 • 353 citations

Nitric Oxide Synthase Is Not a Constituent of the Antimicrobial Armature of Human Mononuclear Phagocytes

1993 • 334 citations

Effector mechanisms of cytolytically activated macrophages. I. Secretion of neutral proteases and effect of protease inhibitors.

1980 • 194 citations

Tumor necrosis factor is an important mediator of tumor cell killing by human monocytes.

1987 • 192 citations

Human colorectal adenocarcinoma cells: differential nitric oxide synthesis determines their ability to aggregate platelets.

1991 • 182 citations

Changes in mechanisms of monocyte/macrophage-mediated cytotoxicity during culture. Reactive oxygen intermediates are involved in monocyte-mediated cytotoxicity, whereas reactive nitrogen intermediates are employed by macrophages in tumor cell killing.

1993 • 173 citations

Human Alveolar and Peritoneal Macrophages Mediate Fungistasis Independently of L-Arginine Oxidation to Nitrite or Nitrate

1990 • 136 citations

Increased Circulating Nitrogen Oxides After Human Tumor Immunotherapy: Correlation With Toxic Hemodynamic Changes

1992 • 129 citations

Human monocyte-mediated tumor cytotoxicity. I. Demonstration of an oxygen-dependent myeloperoxidase-independent mechanism.

1984 • 62 citations

Tumor target-derived soluble factor synergizes with IFN-gamma and IL-2 to activate macrophages for tumor necrosis factor and nitric oxide production to mediate cytotoxicity of the same target.

1992 • 55 citations

Ca2+/calmodulin-dependent nitric oxide synthase activity in the human cervix carcinoma cell line ME-180

1993 • 44 citations

Abilities of activated macrophages to manifest tumoricidal activity and to generate reactive nitrogen intermediates: A comparative study in vitro and ex vivo

1989 • 43 citations

Abundant Production of Nitric Oxide from Murine Macrophages by Direct Stimulation of Tumor Cells

1993 • 41 citations

Tumour-cell-induced production of tumour necrosis factor by monocytes of gastric cancer patients receiving BCG immunotherapy

1993 • 24 citations

Effects of Anti-Transferrin Receptor Antibodies on the Growth of Neoplastic Cells

1992 • 16 citations

TUMOR-CYTOTOXICITY OF NITRIC-OXIDE PRODUCED FROM ALVEOLAR MACROPHAGES DIRECTLY STIMULATED WITH TUMOR-CELLS

1993 • 10 citations

Augmentation of monocyte-mediated cytocidal activity by a low dose tumour necrosis factor measured by the kinetic colorimetric microplate assay

1992 • 3 citations