Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

1989 • 3,067 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

Analysis of membrane and surface protein sequences with the hydrophobic moment plot

1984 • 2,234 citations

Molecular cloning and characterization of the rat NMDA receptor

1991 • 1,780 citations

A Family of AMPA-Selective Glutamate Receptors

1990 • 1,453 citations

Physiological and pathophysiological roles of excitatory amino acids during central nervous system development

1990 • 1,427 citations

Excitatory amino acid receptors in the vertebrate central nervous system.

1989 • 1,316 citations

Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

1990 • 1,234 citations

Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit

1992 • 1,077 citations

Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs

1992 • 1,067 citations

Cloning by functional expression of a member of the glutamate receptor family

1989 • 1,009 citations

Protein Oligomerization in the Endoplasmic Reticulum

1989 • 993 citations

Light and electron immunocytochemical localization of AMPA‐selective glutamate receptors in the rat brain

1992 • 988 citations

Molecular Cloning and Functional Expression of Glutamate Receptor Subunit Genes

1990 • 925 citations

The TINS/TiPS Lecture the molecular biology of mammalian glutamate receptor channels

1993 • 882 citations

Structural Determinants of Ion Flow Through Recombinant Glutamate Receptor Channels

1991 • 827 citations

Identification of a Site in Glutamate Receptor Subunits That Controls Calcium Permeability

1991 • 774 citations

The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins

1993 • 695 citations

Protein degradation in the endoplasmic reticulum

1990 • 659 citations

Knowledge-based prediction of protein structures and the design of novel molecules

1987 • 653 citations

Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA

1991 • 638 citations

Neural mechanisms of form and motion processing in the primate visual system

1994 • 606 citations

A family of glutamate receptor genes: Evidence for the formation of heteromultimeric receptors with distinct channel properties

1990 • 581 citations

Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A

1993 • 581 citations

AMPA glutamate receptor subunits are differentially distributed in rat brain

1993 • 574 citations

Immunochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies. Evidence for a hetero-oligomeric structure in rat brain.

1992 • 505 citations

Regulation of Protein Export From the Endoplasmic Reticulum

1988 • 421 citations

Glutamate receptor channels in rat DRG neurons: Activation by kainate and quisqualate and blockade of desensitization by con A

1990 • 420 citations

N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1

1994 • 419 citations

Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain

1993 • 415 citations

Excitotoxic Amino Acids and Neuropsychiatric Disorders

1990 • 407 citations

Mutational analysis of the glycine-binding site of the NMDA receptor: Structural similarity with bacterial amino acid-binding proteins

1994 • 381 citations

Cloning of a putative glutamate receptor: A low affinity kainate-binding subunit

1992 • 379 citations

Three-dimensional structures of the periplasmic lysine/arginine/ornithine-binding protein with and without a ligand

1993 • 313 citations

Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors.

1992 • 284 citations

Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria.

1993 • 248 citations

Biochemical Characterization and Localization of a Non‐N‐Methyl‐D‐Aspartate Glutamate Receptor in Rat Brain

1992 • 242 citations

Concanavalin A selectively reduces desensitization of mammalian neuronal quisqualate receptors.

1989 • 228 citations

Atomic structures of periplasmic binding proteins and the high-affinity active transport systems in bacteria

1990 • 213 citations

Bench to Bedside: The Glutamate Connection

1992 • 206 citations

Molecular structure of the chick cerebellar kainate-binding subunit of a putative glutamate receptor

1989 • 204 citations

Transmembrane topology of two kainate receptor subunits revealed by N-glycosylation.

1994 • 196 citations

Biochemical and immunocytochemical characterization of antipeptide antibodies to a cloned GluR1 glutamate receptor subunit: Cellular and subcellular distribution in the rat forebrain

1993 • 190 citations

Sequence and expression of a frog brain complementary DNA encoding a kainate-binding protein

1989 • 181 citations

Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors.

1993 • 177 citations

Primary structure and expression of the γ2 subunit of the glutamate receptor channel selective for kainate

1992 • 173 citations

Cloning and complete nucleotide sequence of the Escherichia coli glutamine permease operon (glnHPQ)

1986 • 161 citations

Selective RNA editing and subunit assembly of native glutamate receptors

1994 • 158 citations

Protein chemical characterization and immunocytochemical localization of the NMDA receptor subunit NMDA R1.

1993 • 155 citations

Two periplasmic transport proteins which interact with a common membrane receptor show extensive homology: complete nucleotide sequences.

1981 • 151 citations

Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies.

1994 • 122 citations

Differential assembly of coexpressed glutamate receptor subunits in neurons of rat cerebral cortex

1994 • 108 citations

Transmembrane topology of the glutamate receptor subunit GluR6.

1994 • 107 citations

Crystal structure of the lysine-, arginine-, ornithine-binding protein (LAO) from Salmonella typhimurium at 2.7-A resolution.

1991 • 88 citations

Mutations in a putative agonist binding region of the AMPA‐selective glutamate receptor channel

1992 • 85 citations

Cloning and characterization of a glutamine transport operon of Bacillus stearothermophilus NUB36: effect of temperature on regulation of transcription

1991 • 47 citations

Antibodies to a C‐terminal peptide of the rat brain glutamate receptor subunit, GluR‐A, recognize a subpopulation of AMPA binding sites but not kainate sites

1990 • 44 citations

A deletion in the second cytoplasmic loop of GluR3 produces a dominant negative mutant of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor.

1994 • 11 citations