Physiological and pharmacological profile oftrans-azetidine-2,4-dicarboxylic acid: Metabotropic glutamate receptor agonism and effects on long-term potentiation

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

The metabotropic glutamate receptors: Structure and functions

1995 • 2,269 citations

Differential signal transduction by five splice variants of the PACAP receptor

1993 • 1,185 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path

1973 • 1,140 citations

Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors

1984 • 905 citations

Metabotropic glutamate receptors in brain function and pathology

1993 • 799 citations

Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors

1993 • 736 citations

Glutamate stimulates inositol phosphate formation in striatal neurones

1985 • 734 citations

Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1

1994 • 730 citations

Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat

1993 • 554 citations

A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation

1994 • 405 citations

Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors.

1986 • 399 citations

Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1

1995 • 275 citations

Association Between Brain Temperature and Dentate Field Potentials in Exploring and Swimming Rats

1993 • 268 citations

Characterisation of LTP induced by the activation of glutamate metabotropic receptors in area CA1 of the hippocampus

1993 • 262 citations

Temporal limits on the rise in postsynaptic calcium required for the induction of long-term potentiation

1992 • 258 citations

Inositol 1,4,5-Trisphosphate-Activated Calcium Channels

1992 • 236 citations

Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes.

1992 • 226 citations

Competitive antagonism at metabotropic glutamate receptors by (S) -4-carboxyphenylglycine and (RS) -α-methyl-4-carboxyphenylglycine

1993 • 219 citations

Quisqualate Metabotropic Receptors Modulate NMDA Currents and Facilitate Induction of Long‐Term Potentiation Through Protein Kinase C

1992 • 200 citations

MCPG Antagonizes Metabotropic Glutamate Receptors but not Long‐term Potentiation in the Hippocampus

1994 • 166 citations

Thapsigargin blocks the induction of long-term potentiation in rat hippocampal slices

1992 • 159 citations

Activation of Class II or III Metabotropic Glutamate Receptors Protects Cultured Cortical Neurons Against Excitotoxic Degeneration

1995 • 147 citations

(RS)-alpha-methyl-4-carboxyphenylglycine neither prevents induction of LTP nor antagonizes metabotropic glutamate receptors in CA1 hippocampal neurons

1993 • 114 citations

Activation of metabotropic glutamate receptors is necessary for long-term potentiation in the dentate gyrus and for spatial learning

1994 • 114 citations

Trans-ACPD enhances long-term potentiation in the hippocampus

1991 • 107 citations

Co-activation of metabotropic glutamate and N-methyl-d-aspartate receptors is involved in mechanisms of long-term potentiation maintenance in rat hippocampal ca1 neurons

1993 • 106 citations

Potentiation of dentate synapses initiated by exploratory learning in rats: dissociation from brain temperature, motor activity, and arousal.

1994 • 90 citations

2-Amino-3-phosphonopropionate blocks the induction and maintenance of long-term potentiation in rat hippocampal slices

1991 • 89 citations

Activation of glutamate metabotropic receptors induces long-term potentiation

1992 • 78 citations

Metabotropic glutamate receptor agonist DCG-IV as NMDA receptor agonist in immature rat hippocampal neurons

1994 • 72 citations

Inhibition of long-term potentiation in the dentate gyrus of freely moving rats by the metabotropic glutamate receptor antagonist MCPG

1995 • 67 citations

Regional and developmental profile of modulation of hippocampal synaptic transmission and LTP by AP4-sensitive mGluRs in vivo

1995 • 66 citations

Role of glutamate metabotropic receptors in long-term potentiation in the hippocampus

1995 • 66 citations

2-Amino-4-phosphonobutyrate selectively eliminates late phases of long-term potentiation in rat hippocampus

1989 • 65 citations

An antagonist of the metabotropic glutamate receptor prevents LTP in the dentate gyrus of freely moving rats

1993 • 54 citations

Enhancement of long-term potentiation by the calcium channel agonist Bayer K8644 in CA1 of the rat hippocampus in vitro

1987 • 51 citations

Trans-azetidine-2, 4-dicarboxylic acid activates neuronal metabotropic receptors

1993 • 50 citations

L-2-amino-3-phosphonopropionate blocks late synaptic long-term potentiation

1991 • 44 citations

Synthesis and bioactivity of a new class of rigid glutamate analogs. Modulators of the N-methyl-D-aspartate receptor

1990 • 41 citations

The effects of trans-ACPD on long-term potentiation in the rat hippocampal slice

1991 • 40 citations

Protein Kinase C Modulates Calcium Channels in Isolated Presynaptic Nerve Terminals of Rat Hippocampus

1995 • 40 citations

1S,3R-ACPD dose-dependently induces a slow-onset potentiation in the rat hippocampal CA1 region in vivo

1995 • 32 citations

1S,3R-ACPD dose dependently induces a slow onset potentiation in the dentate gyrus in vivo

1995 • 31 citations

Metabotropic glutamate receptor agonist trans-azetidine-2,4-dicarboxylic acid facilitates maintenance of LTP in the dentate gyrus in vivo

1995 • 28 citations

4-Aminopyridine-mediated increase in long-term potentiation in CA1 of the rat hippocampus

1986 • 28 citations

Profiling of trans-azetidine-2,4-dicarboxylic acid at the human metabotropic glutamate receptors mGlu1b, -2, -4a and -5a

1995 • 27 citations

4‐Bromohomoibotenic Acid Selectively Activates a 1‐Aminocyclopentane‐1S,3R‐Dicarboxylic Acid‐Insensitive Metabotropic Glutamate Receptor Coupled to Phosphoinositide Hydrolysis in Rat Cortical Slices

1994 • 18 citations