Evidence for involvement of phospholipase C-γ2 in signal transduction of platelet-derived growth factor in vascular smooth-muscle cells

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro

1974 • 1,838 citations

The smooth muscle cell in culture

1979 • 1,546 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Studies of Inositol Phospholipid-Specific Phospholipase C

1989 • 914 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Replication of smooth muscle cells in vascular disease.

1986 • 770 citations

The Pathogenesis of Atherosclerosis: Atherogenesis and Inflammation

1989 • 701 citations

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

1990 • 650 citations

Localization of PDGF-B Protein in Macrophages in All Phases of Atherogenesis

1990 • 584 citations

Regulation of differentiated properties and proliferation of arterial smooth muscle cells.

1990 • 556 citations

Regulation of Phospholipase C-γ1 by Profilin and Tyrosine Phosphorylation

1991 • 532 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

The Actin-Binding Protein Profilin Binds to PIP ₂ and Inhibits Its Hydrolysis by Phospholipase C

1990 • 472 citations

Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia.

1981 • 427 citations

Platelet factors stimulate fibroblasts and smooth muscle cells quiescent in plasma serum to proliferate.

1976 • 400 citations

Platelet-derived growth factor. II. Specific binding to cultured cells.

1982 • 366 citations

Functional angiotensin II receptors in cultured vascular smooth muscle cells.

1982 • 346 citations

Antiphosphotyrosine Recovery of Phospholipase C Activity After EGF Treatment of A-431 Cells

1988 • 324 citations

Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene.

1991 • 272 citations

Platelet-Derived Growth Factor (PDGF)-Dependent Association of Phospholipase C-γ with the PDGF Receptor Signaling Complex

1990 • 204 citations

The PtdIns-PLC superfamily and signal transduction

1991 • 190 citations

Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor.

1990 • 188 citations

A short sequence responsible for both phosphoinositide binding and actin binding activities of cofilin.

1991 • 181 citations

Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells

1991 • 168 citations

A Second Type of Rat Phosphoinositide-specific Phospholipase C Containing a src-related Sequence Not Essential for Phosphoinositide-hydrolyzing Activity

1989 • 160 citations

Left and right ventricular myocardial morphometry in fetal, neonatal, and adult sheep

1989 • 140 citations

Physiological quiescence in plasma‐derived serum: Influence of platelet‐derived growth factor on cell growth in culture

1978 • 129 citations

Tissue- and cell type-specific expression of mRNAS for four types of inositol phospholipid-specific phospholipase C

1989 • 114 citations

Platelet-derived growth factor binds specifically to receptors on vascular smooth muscle cells and the binding becomes nondissociable.

1982 • 97 citations

Platelet-derived growth factor increases the in vivo activity of phospholipase C-gamma 1 and phospholipase C-gamma 2.

1991 • 90 citations

Invited review: the cellular pathobiology of atherosclerosis

1981 • 79 citations

Isolation and characterization of a γ-type phosphoinositide-specific phospholipase C (PLC-γ2)

1990 • 52 citations

Tyrosine Kinase Activity Is Essential for the Association of Phospholipase C-γ with the Epidermal Growth Factor Receptor

1990 • 41 citations

Platelet-Derived Growth Factor Increases the In Vivo Activity of Phospholipase C-γ₁ and Phospholipase C-γ₂

1991 • 13 citations

Purification of recombinant SH2SH3 proteins of phospholipase C-γ1 and -γ2 and their inhibitory effect on PIP2-hydrolysis induced by both types of phospholipase C-γ

1992 • 8 citations