A Cancer-associated Aurora A Mutant Is Mislocalized and Misregulated Due to Loss of Interaction with TPX2

Coot: model-building tools for molecular graphics

2004 • 29,122 citations

Phasercrystallographic software

2007 • 19,186 citations

The PyMOL Molecular Graphics System

2002 • 18,218 citations

PHENIX: building new software for automated crystallographic structure determination

2002 • 4,243 citations

Patterns of somatic mutation in human cancer genomes

2007 • 2,975 citations

Mitotic kinases as regulators of cell division and its checkpoints

2001 • 1,503 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

The cellular geography of Aurora kinases

2003 • 1,118 citations

Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization.

1994 • 748 citations

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

2008 • 654 citations

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

2002 • 651 citations

Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells

2003 • 610 citations

Structural Basis of Aurora-A Activation by TPX2 at the Mitotic Spindle

2003 • 591 citations

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53

2003 • 570 citations

Human TPX2 is required for targeting Aurora-A kinase to the spindle

2002 • 563 citations

Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry

2008 • 558 citations

A Novel Mechanism for Activation of the Protein Kinase Aurora A

2003 • 358 citations

A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly

2003 • 341 citations

Aurora kinases link chromosome segregation and cell division to cancer susceptibility

2003 • 341 citations

The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis

1999 • 333 citations

Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases

1999 • 318 citations

Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

2003 • 318 citations

Aurora-A Abrogation of p53 DNA Binding and Transactivation Activity by Phosphorylation of Serine 215

2004 • 307 citations

Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast.

1999 • 306 citations

Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer.

2003 • 300 citations

TheTP53 gene, tobacco exposure, and lung cancer

2003 • 272 citations

Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis

2005 • 252 citations

Cell Cycle-dependent Expression and Centrosome Localization of a Third Human Aurora/Ipl1-related Protein Kinase, AIK3

1999 • 249 citations

The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome

2005 • 234 citations

The Xenopus laevis Aurora-related Protein Kinase pEg2 Associates with and Phosphorylates the Kinesin-related Protein XlEg5

1999 • 218 citations

Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A

2008 • 198 citations

Interaction and Feedback Regulation between STK15/BTAK/Aurora-A Kinase and Protein Phosphatase 1 through Mitotic Cell Division Cycle

2001 • 189 citations

Expression, purification, crystallization, and biochemical characterization of a recombinant protein phosphatase.

1993 • 170 citations

Aurora A activates D-TACC–Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules

2005 • 163 citations

Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway

2000 • 146 citations

Aurora- A/STK15 T + 91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types

2005 • 141 citations

Function and regulation of Maskin, a TACC family protein, in microtubule growth during mitosis

2005 • 134 citations

An Essential Function of the C. elegans Ortholog of TPX2 Is to Localize Activated Aurora A Kinase to Mitotic Spindles

2005 • 121 citations

Interaction of Aurora-A and centrosomin at the microtubule-nucleating site in Drosophila and mammalian cells

2003 • 118 citations

Prediction of Cancer Driver Mutations in Protein Kinases

2008 • 106 citations

Anaphase-Promoting Complex/Cyclosome Controls the Stability of TPX2 during Mitotic Exit

2005 • 99 citations

Crosstalk between Aurora-A and p53: Frequent Deletion or Downregulation of Aurora-A in Tumors from p53 Null Mice

2007 • 71 citations

The putative serine/threonine kinase gene STK15 on chromosome 20q13.2 is amplified in human gliomas

2003 • 59 citations