Carcinogenesis Studies of Human Cells: Reliable In Vitro Models

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro.

1979 • 2,025 citations

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

1991 • 1,946 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Antioncogenes and human cancer.

1993 • 772 citations

Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultured from human squamous cell carcinomas.

1981 • 743 citations

The Emerging Epidemic of Melanoma and Squamous Cell Skin Cancer

1989 • 468 citations

p53 Mutations in human immortalized epithelial cell lines

1993 • 441 citations

Mutual induction of growth factor gene expression by epidermal-dermal cell interaction

1993 • 401 citations

UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement.

1994 • 324 citations

Ras gene mutation and amplification in human nonmelanoma skin cancers

1991 • 276 citations

HUMAN TUMOR SUPPRESSOR GENES

1990 • 266 citations

c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy.

1990 • 212 citations

Progression of human papillomavirus type 18-immortalized human keratinocytes to a malignant phenotype.

1991 • 170 citations

Density-dependent modulation of synthesis of keratins 1 and 10 in the human keratinocyte line HACAT and in ras-transfected tumorigenic clones

1989 • 164 citations

Oncogenes and the molecular origins of cancer

1991 • 142 citations

Growth and Differentiation Characteristics of Transformed Keratinocytes from Mouse and Human Skin in Vitro and in Vivo

1983 • 127 citations

Mesenchyme-mediated and endogenous regulation of growth and differentiation of human skin keratinocytes derived from different body sites

1990 • 110 citations

Environmental modulation of the expression of differentiation and malignancy in six human squamous cell carcinoma cell lines.

1985 • 74 citations

Epidermal morphogenesis and keratin expression in c-Ha-ras-transfected tumorigenic clones of the human HaCaT cell line.

1991 • 66 citations

Isolation and characterization of a spontaneously arising long-lived line of human keratinocytes (NM1)

1987 • 65 citations

Progressive abrogation of TGF‐β‐1 and EGF growth control is associated with tumour progression in ras‐transfected human keratinocytes

1992 • 61 citations

Pharmacology of retinoids in the skin

1989 • 54 citations

Cell Transformation and Radiation-induced Cancer

1990 • 52 citations

Pharmaceutical Applications of Cell and Tissue Culture to Drug Transport

1991 • 47 citations

Malignant progression of an SV40-transformed human epidermal keratinocyte cell line

1987 • 46 citations

Phenotypic and cytogenetic characteristics of different stages during spontaneous transformation of mouse keratinocytes in vitro.

1985 • 40 citations

Environmental induction of differentiation-specific keratins in malignant mouse keratinocyte lines.

1986 • 38 citations

Neoplastic Transformation in Human Cell Culture

1991 • 37 citations

"Trans-differentiation" from epidermal to mesenchymal/myogenic phenotype is associated with a drastic change in cell-cell and cell-matrix adhesion molecules.

1993 • 34 citations

Cell transformation and radiation-induced cancer

1989 • 24 citations

Role of elevated temperature in malignant transformation of mammalian cells in vztro

1980 • 15 citations

In vitro transformation of human skin epithelial cells: Role of RAS oncogene in malignant progression

1990 • 11 citations

11 Heritable Cancer and Tumor Suppressor Genes: A Tentative Connection

1989 • 9 citations

Mammalian cell transformation. Mechanisms of carcinogenesis and assays for carcinogens.

1985 • 7 citations

Altered Regulation of Growth and Differentiation at Different Stages of Transformation of Human Skin Keratinocytes

1991 • 6 citations

Human Keratinocyte Cell Lines

1991 • 6 citations

Genetic Determinants in Carcinogenesis

1993 • 1 citations