Progressive abrogation of TGF‐β‐1 and EGF growth control is associated with tumour progression in ras‐transfected human keratinocytes

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Epidermal growth factor.

1990 • 1,645 citations

Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum-free medium.

1986 • 559 citations

Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers

1991 • 452 citations

Inhibition of Endothelial Regeneration by Type-Beta Transforming Growth Factor from Platelets

1986 • 439 citations

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

1989 • 432 citations

Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation.

1990 • 397 citations

Concomitant loss of transforming growth factor (TGF)-beta receptor types I and II in TGF-beta-resistant cell mutants implicates both receptor types in signal transduction.

1990 • 319 citations

Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II

1991 • 252 citations

c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy.

1990 • 212 citations

The behaviour of human oral squamous cell carcinoma in cell culture

1990 • 176 citations

Characterization of the mouse transforming growth factor-beta 1 promoter and activation by the Ha-ras oncogene.

1991 • 131 citations

Transforming growth factor-beta modulates the high-affinity receptors for epidermal growth factor and transforming growth factor-alpha.

1985 • 111 citations

Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha‐transforming growth factors in ras‐transformed mouse mammary epithelial cells

1987 • 108 citations

Early gene responses to transforming growth factor-beta in cells lacking growth-suppressive RB function.

1991 • 104 citations

Introduction of a Ha-ras oncogene into rat liver epithelial cells and parenchymal hepatocytes confers resistance to the growth inhibitory effects of TGF-beta.

1989 • 70 citations

Escape from transforming growth factor beta control and oncogene cooperation in skin tumor development.

1991 • 67 citations

Production of transforming growth factor-α in human tumour cell lines

1989 • 60 citations

Biological effects and binding properties of transforming growth factor-β on human oral squamous cell carcinoma cells

1990 • 51 citations

Regulation of transforming growth factor beta 1 action by multiple transducing pathways: evidence for both G protein-dependent and -independent signaling.

1989 • 50 citations

Neoplastic Transformation in Human Cell Culture

1991 • 37 citations

Lack of correlation between sensitivity to growth inhibition and receptor number for transforming growth factor beta in human squamous carcinoma cell lines.

1989 • 37 citations

Modifications of cell cycle controlling nuclear proteins by transforming growth factor beta in the HaCaT keratinocyte cell line.

1992 • 32 citations

Tumour Progression in experimental oral carcinogenesis is associated with changes in EGF and TGF-β receptor expression and altered responses to these growth factors

1990 • 30 citations

Transformation of mouse mammary epithelial cells with the Ha‐ras but not with the neu oncogene results in a gene dosage‐dependent increase in transforming growth factor‐α production

1989 • 23 citations

Specific effects of ras oncogene expression on the growth and histogenesis of human epidermal keratinocytes.

1990 • 16 citations

In vitro transformation of human skin epithelial cells: Role of RAS oncogene in malignant progression

1990 • 11 citations