Bcl-2-family proteins and the role of mitochondria in apoptosis

Caspases: Enemies Within

1998 • 6,923 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

2001 • 2,226 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

Endonuclease G is an apoptotic DNase when released from mitochondria

2001 • 1,725 citations

CD95's deadly mission in the immune system

2000 • 1,714 citations

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

2001 • 1,672 citations

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

2002 • 1,617 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane

2002 • 1,443 citations

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

2000 • 1,427 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

BAX and BAK Regulation of Endoplasmic Reticulum Ca ²⁺ : A Control Point for Apoptosis

2003 • 1,363 citations

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

2001 • 1,275 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

A matter of life and death

2002 • 1,251 citations

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

2000 • 1,245 citations

Mitochondria

2003 • 1,233 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Structure of Bax

2000 • 1,066 citations

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

2000 • 1,046 citations

The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

1999 • 1,045 citations

BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

2000 • 1,033 citations

Inhibition of Bax Channel-Forming Activity by Bcl-2

1997 • 1,023 citations

A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

2002 • 1,015 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

2001 • 815 citations

Does nitric oxide modulate mitochondrial energy generation and apoptosis?

2002 • 779 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

2002 • 695 citations

Bax Is Present as a High Molecular Weight Oligomer/Complex in the Mitochondrial Membrane of Apoptotic Cells

2001 • 676 citations

Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

1999 • 659 citations

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet

2002 • 628 citations

Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis

2001 • 620 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

2001 • 578 citations

Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak

1997 • 555 citations

Posttranslational N-Myristoylation of BID as a Molecular Switch for Targeting Mitochondria and Apoptosis

2000 • 555 citations

The Serine Protease Omi/HtrA2 Regulates Apoptosis by Binding XIAP through a Reaper-like Motif

2002 • 533 citations

Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death

1999 • 495 citations

Apoptosis driven by IP3-linked mitochondrial calcium signals

1999 • 492 citations

Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling

1999 • 473 citations

Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis

2003 • 468 citations

Reduced Loading of Intracellular Ca2+ Stores and Downregulation of Capacitative Ca2+Influx in Bcl-2–Overexpressing Cells

2000 • 462 citations

Cardiolipin provides specificity for targeting of tBid to mitochondria

2000 • 462 citations

Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis

2001 • 453 citations

TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO

2002 • 448 citations

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

2000 • 447 citations

Cytochrome C Maintains Mitochondrial Transmembrane Potential and Atp Generation after Outer Mitochondrial Membrane Permeabilization during the Apoptotic Process

2001 • 431 citations

Bcl-2 decreases the free Ca ²⁺ concentration within the endoplasmic reticulum

2000 • 417 citations

Bax Deletion Further Orders the Cell Death Pathway in Cerebellar Granule Cells and Suggests a Caspase-independent Pathway to Cell Death

1997 • 390 citations

Solution Structure of the Proapoptotic Molecule BID

1999 • 387 citations

Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression

2002 • 386 citations

Electron Tomography of Neuronal Mitochondria: Three-Dimensional Structure and Organization of Cristae and Membrane Contacts

1997 • 384 citations

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-XL

1997 • 381 citations

Apoptosis Induction by Caspase-8 Is Amplified through the Mitochondrial Release of Cytochrome c

1998 • 380 citations

Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis

2003 • 326 citations

Bax and Bak Promote Apoptosis by Modulating Endoplasmic Reticular and Mitochondrial Ca2+ Stores

2002 • 321 citations

Interdigital cell death can occur through a necrotic and caspase-independent pathway

1999 • 316 citations

Changes in Endoplasmic Reticulum Luminal Environment Affect Cell Sensitivity to Apoptosis

2000 • 285 citations

Bax, but not Bcl-x _L , decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations

1999 • 267 citations

Preservation of Mitochondrial Structure and Function after Bid- or Bax-Mediated Cytochrome c Release

2000 • 244 citations

Bax-type Apoptotic Proteins Porate Pure Lipid Bilayers through a Mechanism Sensitive to Intrinsic Monolayer Curvature

2002 • 229 citations

A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth

2002 • 224 citations

Bcl-2-dependent modulation of Ca2+ homeostasis and store-operated channels in prostate cancer cells

2002 • 213 citations

Bax-mediated Ca2+ Mobilization Promotes Cytochrome c Release during Apoptosis

2002 • 199 citations

Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein

2002 • 192 citations

The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity

2003 • 170 citations

Molecular Cloning of a Novel Polypeptide, DP5, Induced during Programmed Neuronal Death

1997 • 158 citations

A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c

2001 • 156 citations

Triggering caspase-independent cell death to combat cancer

2002 • 154 citations

BCL-2 Selectively Interacts with the BID-induced Open Conformer of BAK, Inhibiting BAK Auto-oligomerization

2003 • 144 citations

Relief of Extrinsic Pathway Inhibition by the Bid-dependent Mitochondrial Release of Smac in Fas-mediated Hepatocyte Apoptosis

2002 • 134 citations

Characterization of a Novel and Specific Inhibitor for the Pro-apoptotic Protease Omi/HtrA2

2003 • 126 citations

Solution Structure of Human BCL-w

2003 • 123 citations

Direct evidence for membrane pore formation by the apoptotic protein Bax

2002 • 111 citations

The Cell Death-promoting Gene DP5, Which Interacts with the BCL2 Family, Is Induced during Neuronal Apoptosis Following Exposure to Amyloid β Protein

1999 • 99 citations

tcBid promotes Ca2+ signal propagation to the mitochondria: control of Ca2+ permeation through the outer mitochondrial membrane

2002 • 81 citations

Tumors Acquire Inhibitor of Apoptosis Protein (IAP)-mediated Apoptosis Resistance through Altered Specificity of Cytosolic Proteolysis

2003 • 69 citations