Relief of Extrinsic Pathway Inhibition by the Bid-dependent Mitochondrial Release of Smac in Fas-mediated Hepatocyte Apoptosis

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

1999 • 1,927 citations

Endonuclease G is an apoptotic DNase when released from mitochondria

2001 • 1,725 citations

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1998 • 1,394 citations

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

2000 • 1,245 citations

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

2000 • 1,150 citations

A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death

2001 • 1,106 citations

Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death

1999 • 1,024 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

2001 • 987 citations

BID: a novel BH3 domain-only death agonist.

1996 • 921 citations

Caspase activation: The induced-proximity model

1999 • 920 citations

Structural basis of IAP recognition by Smac/DIABLO

2000 • 844 citations

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

2000 • 842 citations

Structural Basis for the Inhibition of Caspase-3 by XIAP

2001 • 763 citations

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

1999 • 750 citations

Pro-caspase-3 Is a Major Physiologic Target of Caspase-8

1998 • 743 citations

Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase Interaction

2002 • 732 citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 • 731 citations

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

2000 • 625 citations

A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases

1998 • 611 citations

Structural Basis of Caspase-7 Inhibition by XIAP

2001 • 567 citations

HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins

2002 • 550 citations

The Serine Protease Omi/HtrA2 Regulates Apoptosis by Binding XIAP through a Reaper-like Motif

2002 • 533 citations

Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1996 • 519 citations

CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis

1996 • 480 citations

Structural Basis of Caspase Inhibition by XIAP

2001 • 473 citations

Characterization of XIAP-Deficient Mice

2001 • 425 citations

Mitochondrial endonuclease G is important for apoptosis in C. elegans

2001 • 416 citations

Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes

2001 • 388 citations

Molecular Determinants of the Caspase-promoting Activity of Smac/DIABLO and Its Role in the Death Receptor Pathway

2000 • 352 citations

FLICE Induced Apoptosis in a Cell-free System

1997 • 343 citations

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

1999 • 339 citations

The Pro-Apoptotic Proteins, Bid and Bax, Cause a Limited Permeabilization of the Mitochondrial Outer Membrane That Is Enhanced by Cytosol

1999 • 316 citations

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

2000 • 311 citations

Caspases Induce Cytochrome c Release from Mitochondria by Activating Cytosolic Factors

1999 • 302 citations

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x_L

1999 • 295 citations

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

1996 • 279 citations

Proapoptotic BH3-only Bcl-2 family members induce cytochromecrelease, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity

2000 • 273 citations

Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3

2001 • 248 citations

A Sequential Two-Step Mechanism for the Production of the Mature p17:p12 Form of Caspase-3 in Vitro

1997 • 237 citations

Bcl-2 and Bcl-xL Inhibit CD95-mediated Apoptosis by Preventing Mitochondrial Release of Smac/DIABLO and Subsequent Inactivation of X-linked Inhibitor-of-Apoptosis Protein

2002 • 235 citations

Characterization of seven murine caspase family members

1997 • 207 citations

Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9

2001 • 198 citations

TNF-α Signals Apoptosis through a Bid-Dependent Conformational Change in Bax that Is Inhibited by E1B 19K

2000 • 196 citations

Bid-induced Cytochrome c Release Is Mediated by a Pathway Independent of Mitochondrial Permeability Transition Pore and Bax

2000 • 179 citations

A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c

2001 • 156 citations

Protection against Fas Receptor-Mediated Apoptosis in Hepatocytes and Nonparenchymal Cells by a Caspase-8 Inhibitor in Vivo: Evidence for a Postmitochondrial Processing of Caspase-8

2000 • 130 citations

Activation of Pro-death Bcl-2 Family Proteins and Mitochondria Apoptosis Pathway in Tumor Necrosis Factor-α-induced Liver Injury

2001 • 123 citations

A Mouse Fas-Associated Protein with Homology to the Human Mort1/FADD Protein Is Essential for Fas-Induced Apoptosis

1996 • 117 citations

In Vivo Evidence That Caspase-3 Is Required for Fas-Mediated Apoptosis of Hepatocytes

1999 • 103 citations

Resistance to Granzyme B-mediated Cytochrome c Release in Bak-deficient Cells

2001 • 71 citations

Inhibitor of apoptosis protein hILP undergoes caspase-mediated cleavage during T lymphocyte apoptosis.

2000 • 63 citations

Molecular characterization of mouse and rat CPP32 beta gene encoding a cysteine protease resembling interleukin-1 beta converting enzyme and CED-3.

1996 • 48 citations

E1A-induced Processing of Procaspase-8 Can Occur Independently of FADD and Is Inhibited by Bcl-2

1998 • 35 citations