Meeting Report: Signaling Schemes for TGF-βA review of the meeting "The TGF-β Superfamily: Signaling and Development," FASEB Summer Research Conference, Tucson, Arizona, 7 to 12 July 2001.

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

How cells read TGF-β signals

2000 • 1,843 citations

Regulation of myostatin activity and muscle growth

2001 • 1,536 citations

Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation

2000 • 1,299 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

Transforming Growth Factor-β1 Mediates Epithelial to Mesenchymal Transdifferentiation through a RhoA-dependent Mechanism

2001 • 993 citations

Phosphatidylinositol 3-Kinase Function Is Required for Transforming Growth Factor β-mediated Epithelial to Mesenchymal Transition and Cell Migration

2000 • 956 citations

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.

1994 • 937 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

2001 • 828 citations

Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

2000 • 823 citations

GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.

1995 • 682 citations

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.

1996 • 680 citations

TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis

1998 • 630 citations

TGF-β/Smad3 Signals Repress Chondrocyte Hypertrophic Differentiation and Are Required for Maintaining Articular Cartilage

2001 • 614 citations

Smad2 role in mesoderm formation, left–right patterning and craniofacial development

1998 • 600 citations

Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.

1995 • 574 citations

Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated Transcription

1999 • 534 citations

Role of Transforming Growth Factor-beta Signaling in Cancer

2000 • 525 citations

Genetic programs of epithelial cell plasticity directed by transforming growth factor-β

2001 • 520 citations

TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

2001 • 514 citations

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

2001 • 506 citations

TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

2001 • 479 citations

Smurf2 Is a Ubiquitin E3 Ligase Mediating Proteasome-dependent Degradation of Smad2 in Transforming Growth Factor-β Signaling

2000 • 473 citations

Expression of a Truncated, Kinase-Defective TGF-β Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and Osteoarthritis

1997 • 466 citations

TGF-β type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells

1999 • 419 citations

TGF-β signaling by Smad proteins

2000 • 406 citations

Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation.

1990 • 397 citations

Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF-β

2000 • 392 citations

Role of Smad Proteins and Transcription Factor Sp1 in p21Waf1/Cip1 Regulation by Transforming Growth Factor-β

2000 • 389 citations

TGF-β inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3

2001 • 383 citations

Nodal Signals to Smads through Cripto-Dependent and Cripto-Independent Mechanisms

2001 • 377 citations

Requirement of Type III TGF-β Receptor for Endocardial Cell Transformation in the Heart

1999 • 376 citations

The TGFβ Receptor Activation Process

2001 • 360 citations

TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradation

2001 • 304 citations

Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif

2000 • 277 citations

Latency, activation, and binding proteins of TGF-?

2001 • 262 citations

Transforming Growth Factor β1 Induces Nuclear Export of Inhibitory Smad7

1998 • 240 citations

Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN

2001 • 218 citations

Inhibition of TGF-β receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass

1999 • 210 citations

Twisted gastrulation can function as a BMP antagonist

2001 • 202 citations

The Type II Activin Receptors Are Essential for Egg Cylinder Growth, Gastrulation, and Rostral Head Development in Mice

1999 • 192 citations

The latent transforming growth factor β binding protein (LTBP) family

2000 • 176 citations

Proteolytic cleavage of Chordin as a switch for the dual activities of Twisted gastrulation in BMP signaling

2001 • 153 citations

The Serine/Threonine Transmembrane Receptor ALK2 Mediates Müllerian Inhibiting Substance Signaling

2001 • 150 citations

Interplay between bone morphogenetic proteins and cognate binding proteins in bone and cartilage development: noggin, chordin and DAN.

2001 • 135 citations

Smad7 mediates apoptosis induced by transforming growth factor β in prostatic carcinoma cells

2000 • 135 citations

A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction.

2000 • 132 citations

Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses.

1996 • 132 citations

Sorting Nexin 6, a Novel SNX, Interacts with the Transforming Growth Factor-β Family of Receptor Serine-Threonine Kinases

2001 • 130 citations

A novel Smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-β signal transduction

2000 • 121 citations

Schnurri mediates Dpp-dependent repression of brinker transcription

2000 • 119 citations

The latent transforming growth factor β binding protein (LTBP) family

2000 • 117 citations

Nodal Signaling Uses Activin and Transforming Growth Factor-β Receptor-regulated Smads

2001 • 114 citations

NEW EMBO MEMBER'S REVIEW: Nuclear interpretation of Dpp signaling in Drosophila

2001 • 114 citations

Smad7 inhibits the survival nuclear factor κB and potentiates apoptosis in epithelial cells

2001 • 110 citations

Evidence for a Role of the JNK Cascade in Smad7-mediated Apoptosis

2001 • 102 citations

Transforming Growth Factor-β Receptor-associated Protein 1 Is a Smad4 Chaperone

2001 • 93 citations

Fucosylation of Cripto Is Required for Its Ability to Facilitate Nodal Signaling

2001 • 89 citations

Direct transcriptional control of the Dpp target omb by the DNA binding protein Brinker

2000 • 86 citations

A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1

2000 • 86 citations

Slug Is a Mediator of Epithelial–Mesenchymal Cell Transformation in the Developing Chicken Heart

1999 • 73 citations

Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation

2000 • 65 citations

Regulation of activin's access to the cell: why is Mother Nature such a control freak?

2000 • 65 citations

Mechanisms of Transforming Growth Factor-β Receptor Endocytosis and Intracellular Sorting Differ between Fibroblasts and Epithelial Cells

2001 • 53 citations

TGFβ Type III and TGFβ Type II receptors have distinct activities during epithelial–mesenchymal cell transformation in the embryonic heart

2001 • 45 citations

Schnurri interacts with Mad in a Dpp‐dependent manner

2000 • 32 citations

New Developments for TGFβ

2001 • 13 citations