Computational Elucidation of the Structural Basis of Ligand Binding to the Dopamine 3 Receptor through Docking and Homology Modeling

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

1998 • 10,251 citations

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

Automated docking of flexible ligands: Applications of autodock

1996 • 1,500 citations

Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA

1991 • 859 citations

An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors 1 1Edited by R. Huber

1997 • 639 citations

Localization of brain reinforcement mechanisms: intracranial self-administration and intracranial place-conditioning studies

1999 • 573 citations

Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist

1999 • 565 citations

Molecular dynamics simulation of a bilayer of 200 lipids in the gel and in the liquid crystal phase

1993 • 473 citations

Modulation of Cocaine Self-Administration in the Rat Through D-3 Dopamine Receptors

1993 • 452 citations

Structural Mimicry in G Protein-Coupled Receptors: Implications of the High-Resolution Structure of Rhodopsin for Structure-Function Analysis of Rhodopsin-Like Receptors

2001 • 442 citations

Circadian rhythms in olfactory responses of Drosophila melanogaster

1999 • 316 citations

A Single Glycine Residue at the Entrance to the First Membrane-Spanning Domain of the γ-Aminobutyric Acid Type A Receptor β₂Subunit Affects Allosteric Sensitivity to GABA and Anesthetics

2000 • 271 citations

Mesolimbic Dopamine D3 Receptors and Use of Antipsychotics in Patients With Schizophrenia

1997 • 236 citations

Dopamine receptors—physiological understanding to therapeutic intervention potential

1999 • 230 citations

Mesocorticolimbic Dopamine Systems and Reward

1988 • 207 citations

Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor.

1996 • 190 citations

Dopamine D3 Receptor Partial Agonists and Antagonists as Potential Drug Abuse Therapeutic Agents

2005 • 183 citations

Selective Plasma Hydrolysis of Glucocorticoid γ-Lactones and Cyclic Carbonates by the Enzyme Paraoxonase: An Ideal Plasma Inactivation Mechanism

1999 • 177 citations

Site-directed mutagenesis of the human dopamine D2 receptor

1992 • 165 citations

Mapping the binding-site crevice of the dopamine D2 receptor by the substituted-cysteine accessibility method

1995 • 162 citations

A Cluster of Aromatic Residues in the Sixth Membrane-Spanning Segment of the Dopamine D2 Receptor Is Accessible in the Binding-Site Crevice

1998 • 159 citations

D3 dopamine receptor, behavioral sensitization, and psychosis

2001 • 134 citations

Molecular Modeling of the Three-Dimensional Structure of Dopamine 3 (D₃) Subtype Receptor: Discovery of Novel and Potent D₃Ligands through a Hybrid Pharmacophore- and Structure-Based Database Searching Approach

2003 • 128 citations

A cysteine residue in the third membrane-spanning segment of the human D2 dopamine receptor is exposed in the binding-site crevice.

1994 • 121 citations

Regional neuropathology in schizophrenia: Where are we? Where are we going?

1993 • 119 citations

substituted (S)-Phenylpiperidines and Rigid Congeners as Preferential Dopamine Autoreceptor Antagonists: Synthesis and Structure-Activity Relationships

1994 • 110 citations

Associative and limbic regions of monkey striatum express high levels of dopamine D₃ receptors: effects of MPTP and dopamine agonist replacement therapies

1998 • 108 citations

Residues in the Fifth Membrane-Spanning Segment of the Dopamine D2 Receptor Exposed in the Binding-Site Crevice

1995 • 102 citations

Lack of Discrimination by Agonists for D2 and D3 Dopamine Receptors

1995 • 102 citations

Dopamine D4/D2 Receptor Selectivity Is Determined by A Divergent Aromatic Microdomain Contained within the Second, Third, and Seventh Membrane-Spanning Segments

1999 • 95 citations

Contribution of Serine Residues to Constitutive and Agonist-Induced Signaling via the D_2SDopamine Receptor: Evidence for Multiple, Agonist-Specific Active Conformations

1998 • 87 citations

Dopamine D3 Receptor Ligands with Antagonist Properties

2002 • 75 citations

Electrostatic and Aromatic Microdomains within the Binding-Site Crevice of the D2 Receptor: Contributions of the Second Membrane-Spanning Segment

1999 • 69 citations

Conserved aromatic residues in the transmembrane region VI of the V_1a vasopressin receptor differentiate agonist vs. antagonist ligand binding

2000 • 61 citations

The Fourth Transmembrane Segment of the Dopamine D2 Receptor: Accessibility in the Binding-Site Crevice and Position in the Transmembrane Bundle

2000 • 57 citations

CoMFA-Based Prediction of Agonist Affinities at Recombinant Wild Type versus Serine to Alanine Point Mutated D2 Dopamine Receptors

2000 • 53 citations

D₃ Receptors and the Actions of Neuroleptics in the Ventral Striatopallidal System of Schizophrenics

1999 • 51 citations

Design, Synthesis and Pharmacological Evaluation of 5-Hydroxytryptamine_1aReceptor Ligands to Explore the Three-Dimensional Structure of the Receptor

2002 • 47 citations

Effect of Multiple Serine/Alanine Mutations in the Transmembrane Spanning Region V of the D₂ Dopamine Receptor on Ligand Binding

2000 • 44 citations

Role of Conserved Serine Residues in the Interaction of Agonists with D₃ Dopamine Receptors

1999 • 36 citations

Contributions of cysteine 114 of the human D3 dopamine receptor to ligand binding and sensitivity to external oxidizing agents

1998 • 21 citations

Interactions of ligands with active and inactive conformations of the dopamine D2 receptor

1998 • 20 citations

Identification of Transmembrane Regions Critical for Ligand Binding to the Human D₃Dopamine Receptor Using Various D₃/D₁Transmembrane Chimeras

1998 • 20 citations

Mutagenesis of the Human 5-HT_1BReceptor: Differences from the Closely Related 5-HT_1AReceptor and the Role of Residue F331 in Signal Transduction

1998 • 16 citations

Toward a Molecular Understanding of Psychostimulant Actions Using Genetically Engineered Dopamine Receptor Knockout Mice as Model Systems

2001 • 15 citations

[3H](+)S 14297: A novel, selective radioligand at cloned human dopamine D3 receptors

1995 • 10 citations

Site-directed mutagenesis of Tyr417 in the rat D2 dopamine receptor

1994 • 9 citations

[The role of uridine in the synthesis of phage specific DNA in the cells of Escherichia coli infected by T2 phage].

1970 • 3 citations

The Estimation of Aromatic Amidines.

1945 • 2 citations