Drug Discovery: A Historical Perspective

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

A Hot Spot of Binding Energy in a Hormone-Receptor Interface

1995 • 1,943 citations

Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen

1999 • 1,684 citations

Selective antagonists of benzodiazepines

1981 • 1,235 citations

Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda

1989 • 810 citations

Pharmacological Rescue of Mutant p53 Conformation and Function

1999 • 794 citations

The Role of a Common Variant of the Cholesteryl Ester Transfer Protein Gene in the Progression of Coronary Atherosclerosis

1998 • 634 citations

A humanized antibody that binds to the interleukin 2 receptor.

1989 • 624 citations

Carbonic anhydrase. Its preparation and properties

1933 • 622 citations

On the reaction of cells and of nerve‐endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari

1905 • 581 citations

PENICILLIN AS A CHEMOTHERAPEUTIC AGENT

1940 • 572 citations

Antibody phage display technology and its applications

1998 • 506 citations

Structural genomics: beyond the Human Genome Project

1999 • 385 citations

Evolution and the genetics of populations. Vol. 1. Genetic and biométrie foundations.

1968 • 369 citations

THE MAMMALIAN LOW-DENSITY LIPOPROTEIN RECEPTOR FAMILY

1999 • 362 citations

Discovery, biochemistry and biology of lovastatin

1988 • 348 citations

Designed molecules that fold to mimic protein secondary structures

1999 • 204 citations

Predicting ligand binding to proteins by affinity fingerprinting

1995 • 202 citations

Phage-display technology – finding a needle in a vast molecular haystack

1999 • 201 citations

Population statistics of protein structures: lessons from structural classifications

1997 • 168 citations

How many leads from HTS?

1999 • 151 citations

Signaling antibodies in cancer therapy

1999 • 127 citations

Ueber das Morphium, eine neue salzfähige Grundlage, und die Mekonsäure, als Hauptbestandtheile des Opiums

1817 • 125 citations

The Effect of Sulfanilamide on Salt and Water Excretion in Congestive Heart Failure

1949 • 115 citations

The Molecular Basis for Growth Hormone–Receptor Interactions

1993 • 114 citations

In Quest of Tomorrow’s Medicines

1999 • 105 citations

Strategies for expressing human antibody repertoires in transgenic mice

1996 • 94 citations

Innovation Deficit in the Pharmaceutical Industry

1996 • 83 citations

Bioactive Diversity and Screening Library Selection via Affinity Fingerprinting

1998 • 67 citations

Innovation deficit revisited: reflections on the productivity of pharmaceutical R&D

1998 • 55 citations

Humanized antibodies

1993 • 52 citations

Drug discovery; a casebook and analysis

1991 • 49 citations

Leptin concentrations do not predict weight gain: The Mexico City Diabetes Study

1998 • 41 citations

Drug Discovery

1990 • 37 citations

Reticulum cell sarcoma and lymphosarcoma

1968 • 33 citations

A Repeat Polymorphism in Interleukin–4 Gene Is Highly Associated with Specific Clinical Phenotypes of Asthma

1999 • 30 citations

Pharmaceutical innovation between scientific opportunities and economic constraints

1997 • 30 citations

Classic drug targets

1997 • 28 citations

Schmiedeberg in Strassburg 1872–1918: The making of modern pharmacology

1978 • 26 citations

Diabetes: from phenotypes to genotypes.

1997 • 23 citations

Discovery and Development of a Novel Immunosuppressant, Tacrolimus Hydrate

1997 • 21 citations

Recent advances in the molecular genetics of hypertension

1996 • 18 citations

Monoclonal antibody therapy for B cell non-Hodgkin’s lymphomas: emerging concepts of a tumour-targeted strategy

1999 • 17 citations

The Evolution Of Chemistry: A History Of Its Ideas, Methods, And Materials

1952 • 15 citations

Interaction with Complement Receptor 1 (CD35) Leads to Amelioration of Sepsis‐Triggered Mortality but Aggravation of Arthritis During Staphylococcus aureus Infection

1999 • 11 citations

Onchocerciasis ? A potential revolution in its treatment

1987 • 10 citations

Macromolecular crystallography with a third-generation synchrotron source

1999 • 8 citations

Drug Research: Merging Experimental Pharmacology and Chemistry

1999 • 1 citations