Structure of rhodopsin and the metarhodopsin I photointermediate

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints

2003 • 2,754 citations

Molecular tinkering of G protein-coupled receptors: an evolutionary success

1999 • 1,479 citations

Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin

1996 • 1,159 citations

The Retinal Conformation and its Environment in Rhodopsin in Light of a New 2.2 Å Crystal Structure

2004 • 1,025 citations

Projection structure of rhodopsin

1993 • 758 citations

Structure of Bovine Rhodopsin in a Trigonal Crystal Form

2004 • 718 citations

Roles of G‐protein‐coupled receptor dimerization

2004 • 668 citations

Functional role of internal water molecules in rhodopsin revealed by x-ray crystallography

2002 • 662 citations

An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors 1 1Edited by R. Huber

1997 • 639 citations

Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function

2002 • 580 citations

Drug Design Strategies for Targeting G-Protein-Coupled Receptors

2002 • 500 citations

Arrangement of rhodopsin transmembrane α-helices

1997 • 449 citations

Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation

2005 • 435 citations

β2 Adrenergic Receptor Activation

2002 • 405 citations

Historical review: A brief history and personal retrospective of seven-transmembrane receptors

2004 • 403 citations

Rhodopsin structure, dynamics, and activation: A perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking

2003 • 354 citations

Role of the conserved NPxxY(x) _5,6 F motif in the rhodopsin ground state and during activation

2003 • 337 citations

Sequential Binding of Agonists to the β2 Adrenoceptor

2003 • 333 citations

The Binding Site of Aminergic G Protein–Coupled Receptors: The Transmembrane Segments and Second Extracellular Loop

2002 • 317 citations

Electron crystallography reveals the structure of metarhodopsin I

2004 • 297 citations

The Fourth Transmembrane Segment Forms the Interface of the Dopamine D2 Receptor Homodimer

2003 • 285 citations

Low resolution structure of bovine rhodopsin determined by electron cryo-microscopy

1995 • 278 citations

Probing the β2 Adrenoceptor Binding Site with Catechol Reveals Differences in Binding and Activation by Agonists and Partial Agonists

2005 • 260 citations

Structure-based Drug Discovery Using GPCR Homology Modeling: Successful Virtual Screening for Antagonists of the Alpha1A Adrenergic Receptor

2005 • 232 citations

The G protein‐coupled receptor rhodopsin in the native membrane

2004 • 224 citations

Projection structure of frog rhodopsin in two crystal forms.

1995 • 220 citations

Movement of Retinal Along the Visual Transduction Path

2000 • 218 citations

The second extracellular loop of the dopamine D₂receptor lines the binding-site crevice

2004 • 200 citations

Retinal counterion switch in the photoactivation of the G protein-coupled receptor rhodopsin

2003 • 195 citations

Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR

2005 • 155 citations

Essential role for the second extracellular loop in C5a receptor activation

2005 • 155 citations

Counterion displacement in the molecular evolution of the rhodopsin family

2004 • 148 citations

Coupling of retinal isomerization to the activation of rhodopsin

2004 • 134 citations

Protein crystallography microdiffraction

2005 • 116 citations

An Activation Switch in the Rhodopsin Family of G Protein-coupled Receptors

2005 • 110 citations

Phosphatidylethanolamine Enhances Rhodopsin Photoactivation and Transducin Binding in a Solid Supported Lipid Bilayer as Determined Using Plasmon-Waveguide Resonance Spectroscopy

2004 • 107 citations

Structural origins of constitutive activation in rhodopsin: Role of the K296/E113 salt bridge

2004 • 105 citations

Small is beautiful: protein micro-crystallography

1998 • 104 citations

Changes in Interhelical Hydrogen Bonding upon Rhodopsin Activation

2005 • 103 citations

Rhodopsin Activation Exposes a Key Hydrophobic Binding Site for the Transducin α-Subunit C Terminus

2004 • 102 citations

The Ants Go Marching Two by Two: Oligomeric Structure of G-Protein-Coupled Receptors

2004 • 97 citations

Characterisation of an improved two-dimensional p22121 crystal from bovine rhodopsin

1998 • 95 citations

Activation of G-protein Gα subunits by receptors through Gα–Gβ and Gα–Gγ interactions

2003 • 93 citations

Protein microcrystals and the design of a microdiffractometer: current experience and plans at EMBL and ESRF/ID13

1999 • 77 citations

Mutant G protein α subunit activated by Gβγ: A model for receptor activation?

2001 • 76 citations

Toward the active conformations of rhodopsin and the β₂‐adrenergic receptor

2004 • 75 citations

Three-dimensional structure of an invertebrate rhodopsin and basis for ordered alignment in the photoreceptor membrane 1 1Edited by D. Rees

2001 • 74 citations

Role of the Retinal Hydrogen Bond Network in Rhodopsin Schiff Base Stability and Hydrolysis

2004 • 71 citations

Projection Structure of an Invertebrate Rhodopsin

1996 • 64 citations

Complex of an Active μ-Opioid Receptor with a Cyclic Peptide Agonist Modeled from Experimental Constraints

2004 • 61 citations

Crystals of Native and Modified Bovine Rhodopsins and Their Heavy Atom Derivatives

2004 • 61 citations

Water and Peptide Backbone Structure in the Active Center of Bovine Rhodopsin

1997 • 60 citations

Structure and function in rhodopsin: Topology of the C-terminal polypeptide chain in relation to the cytoplasmic loops

1997 • 59 citations

Location and nature of the residues important for ligand recognition in G-protein coupled receptors

2004 • 56 citations

The Ring of the Rhodopsin Chromophore in a Hydrophobic Activation Switch Within the Binding Pocket

2004 • 47 citations

The Three-dimensional Structure of Bovine Rhodopsin Determined by Electron Cryomicroscopy

2003 • 46 citations

Pronounced Conformational Changes following Agonist Activation of the M3 Muscarinic Acetylcholine Receptor

2005 • 39 citations

Recent developments in microdiffraction on protein crystals

2003 • 36 citations

Rhodopsin Photoproducts in 2D Crystals

2004 • 30 citations

Time-Resolved Photointermediate Changes in Rhodopsin Glutamic Acid 181 Mutants

2004 • 25 citations

[7] Preparation and analysis of two-dimensional crystals of rhodopsin

2000 • 23 citations

X-ray crystallographic studies for ligand–protein interaction changes in rhodopsin

2004 • 21 citations

Molecular mechanisms of GABAB receptor activation: new insights from the mechanism of action of CGP7930, a positive allosteric modulator

2004 • 19 citations

X-ray diffraction of heavy-atom labelled two-dimensional crystals of rhodopsin identifies the position of cysteine 140 in helix 3 and cysteine 316 in helix 8

2002 • 18 citations