The Deubiquitinating Enzymes

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

Structure of 20S proteasome from yeast at 2.4Å resolution

1997 • 2,211 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

1996 • 1,680 citations

Recognition of the polyubiquitin proteolytic signal

2000 • 1,651 citations

A Multiubiquitin Chain Is Confined to Specific Lysine in a Targeted Short-Lived Protein

1989 • 1,463 citations

[31] Affinity chromatography

1971 • 1,407 citations

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

1992 • 1,402 citations

A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2

1997 • 1,221 citations

Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

1995 • 960 citations

The Neuron-Specific Protein PGP 9.5 Is a Ubiquitin Carboxyl-Terminal Hydrolase

1989 • 864 citations

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1995 • 862 citations

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

1987 • 850 citations

A Proteolytic Pathway That Recognizes Ubiquitin as a Degradation Signal

1995 • 804 citations

A 26 S protease subunit that binds ubiquitin conjugates.

1994 • 759 citations

A new protease required for cell-cycle progression in yeast

1999 • 718 citations

The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis

1989 • 711 citations

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

1998 • 688 citations

Regulation of ubiquitin‐dependent processes by deubiquitinating enzymes

1997 • 576 citations

A Ubiquitin Mutant with Specific Defects in DNA Repair and Multiubiquitination

1995 • 547 citations

The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer

1997 • 543 citations

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

1999 • 505 citations

The yeast ubiquitin genes: a family of natural gene fusions.

1987 • 500 citations

Characterization of NEDD8, a Developmentally Down-regulated Ubiquitin-like Protein

1997 • 484 citations

Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

1997 • 451 citations

Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin.

1987 • 430 citations

Ubiquitination

1991 • 430 citations

The interferon-inducible 15-kDa ubiquitin homolog conjugates to intracellular proteins.

1992 • 420 citations

Substrate Specificity of Deubiquitinating Enzymes: Ubiquitin C-Terminal Hydrolases

1998 • 386 citations

The immunochemical detection and quantitation of intracellular ubiquitin-protein conjugates.

1985 • 383 citations

The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene

1993 • 379 citations

[32] Families of cysteine peptidases

1994 • 362 citations

Ubiquitin carboxyl‐terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases

1990 • 351 citations

Complete amino acid sequence of ubiquitin, an adenylate cyclase stimulating polypeptide probably universal in living cells

1975 • 350 citations

Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant.

1994 • 347 citations

Modification of yeast Cdc53p by the ubiquitin-related protein Rub1p affects function of the SCFCdc4 complex

1998 • 317 citations

The yeast ubiquitin gene: head-to-tail repeats encoding a polyubiquitin precursor protein

1984 • 313 citations

Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins.

1982 • 293 citations

Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T

1995 • 292 citations

The Doa4 Deubiquitinating Enzyme Is Required for Ubiquitin Homeostasis in Yeast

1999 • 285 citations

Structural basis for the specificity of ubiquitin C-terminal hydrolases

1999 • 279 citations

Protein Degradation or Regulation: Ub the Judge

1996 • 275 citations

Control of Cell Fate by a Deubiquitinating Enzyme Encoded by the fat facets Gene

1995 • 262 citations

Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family

1992 • 250 citations

The short-lived MAT alpha 2 transcriptional regulator is ubiquitinated in vivo.

1991 • 242 citations

Surface hydrophobic residues of multiubiquitin chains essential for proteolytic targeting.

1996 • 240 citations

Inhibition of NF-kappa B cellular function via specific targeting of the Ikappa B-ubiquitin ligase

1997 • 238 citations

Stress resistance in Saccharomyces cerevisiae is strongly correlated with assembly of a novel type of multiubiquitin chain.

1994 • 238 citations

In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome

1997 • 235 citations

Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 Å resolution

1997 • 229 citations

A Deubiquitinating Enzyme Interacts with SIR4 and Regulates Silencing in S. cerevisiae

1996 • 228 citations

Increase in ubiquitin-protein conjugates concomitant with the increase in proteolysis in rat skeletal muscle during starvation and atrophy denervation

1995 • 228 citations

Kinetic and Mechanistic Studies on the Hydrolysis of Ubiquitin C-Terminal 7-Amido-4-Methylcoumarin by Deubiquitinating Enzymes

1998 • 228 citations

Novel Multiubiquitin Chain Linkages Catalyzed by the Conjugating Enzymes E2EPF and RAD6 Are Recognized by 26 S Proteasome Subunit 5

1996 • 221 citations

Role of I Bα Ubiquitination in Signal-induced Activation of NF- B in Vivo

1996 • 216 citations

Epitope-tagged ubiquitin. A new probe for analyzing ubiquitin function.

1991 • 212 citations

Substrate Binding and Catalysis by Ubiquitin C-Terminal Hydrolases: Identification of Two Active Site Residues

1996 • 211 citations

PA700, an ATP-dependent activator of the 20 S proteasome, is an ATPase containing multiple members of a nucleotide-binding protein family.

1994 • 200 citations

Viral cytopathogenicity correlated with integration of ubiquitin-coding sequences

1991 • 193 citations

UBPY: a growth-regulated human ubiquitin isopeptidase

1998 • 191 citations

Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes.

1987 • 189 citations

The fat facets gene is required for Drosophila eye and embryo development

1992 • 187 citations

Ubiquitin carboxyl-terminal hydrolase acts on ubiquitin carboxyl-terminal amides.

1985 • 187 citations

DUB-1, a deubiquitinating enzyme with growth-suppressing activity.

1996 • 170 citations

Yeast ubiquitin-like genes are involved in duplication of the microtubule organizing center.

1996 • 165 citations

A ubiquitin C-terminal isopeptidase that acts on polyubiquitin chains. Role in protein degradation.

1992 • 161 citations

Cloning and functional analysis of the ubiquitin-specific protease gene UBP1 of Saccharomyces cerevisiae

1991 • 161 citations

Cleavage of the C-Terminus of NEDD8 by UCH-L3

1998 • 158 citations

Proteolysis: The proteasome: a protein-degrading organelle?

1995 • 155 citations

Structure of Tetraubiquitin Shows How Multiubiquitin Chains Can Be Formed

1994 • 151 citations

Stimulation of ATP-dependent proteolysis requires ubiquitin with the COOH-terminal sequence Arg-Gly-Gly.

1981 • 150 citations

Roles of Ubiquitinylation in Proteolysis and Cellular Regulation

1995 • 150 citations

Cloning of a cDNA Which Encodes a Novel Ubiquitin-like Protein

1993 • 146 citations

Conjugation of the 15-kDa Interferon-induced Ubiquitin Homolog Is Distinct from That of Ubiquitin

1996 • 143 citations

Two-dimensional proton NMR study of human ubiquitin: a main chain directed assignment and structure analysis

1987 • 142 citations

A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain.

1990 • 141 citations

Comparison of the three-dimensional structures of human, yeast, and oat ubiquitin.

1987 • 138 citations

A uniform isopeptide-linked multiubiquitin chain is sufficient to target substrate for degradation in ubiquitin-mediated proteolysis.

1990 • 136 citations

Comparisons of neuronal (PGP 9.5) and non-neuronal ubiquitin C-terminal hydrolases

1992 • 130 citations

Detection, resolution and nomenclature of multiple ubiquitin carboxyl-terminal esterases from bovine calf thymus

1989 • 129 citations

Ubiquitin C-terminal hydrolase activity associated with the 26 S protease complex.

1993 • 125 citations

Coordinated Induction of the Ubiquitin Conjugation Pathway Accompanies the Developmentally Programmed Death of Insect Skeletal Muscle

1995 • 124 citations

The genomic organization and transcription of the ubiquitin genes of Trypanosoma cruzi.

1988 • 124 citations

Activation of the ubiquitin-ATP-dependent proteolytic system in skeletal muscle during fasting and denervation atrophy.

1991 • 122 citations

Sequential 1H NMR Assignments and Secondary Structure Identification of Human Ubiquitin

1987 • 114 citations

The Hydrophobic Effect Contributes to Polyubiquitin Chain Recognition

1998 • 112 citations

Specificity of the Ubiquitin Isopeptidase in the PA700 Regulatory Complex of 26 S Proteasomes

1997 • 111 citations

DUB-2 Is a Member of a Novel Family of Cytokine-inducible Deubiquitinating Enzymes

1997 • 111 citations

The dynamics of ubiquitin pools within cultured human lung fibroblasts.

1987 • 104 citations

Mechanism of ubiquitin carboxyl-terminal hydrolase. Borohydride and hydroxylamine inactivate in the presence of ubiquitin.

1986 • 102 citations

Alcohol-induced conformational changes of ubiquitin

1986 • 101 citations

Sequential proton NMR assignments and secondary structure identification of human ubiquitin

1987 • 97 citations

The bacterially expressed yeast CDC34 gene product can undergo autoubiquitination to form a multiubiquitin chain-linked protein.

1993 • 96 citations

Multiubiquitin chains linked through lysine 48 are abundant in vivo and are competent intermediates in the ubiquitin proteolytic pathway.

1993 • 94 citations

PGP9.5, a ubiquitin C-terminal hydrolase; pattern of mRNA and protein expression during neural development in the mouse

1995 • 92 citations

Isopeptidase: a novel eukaryotic enzyme that cleaves isopeptide bonds.

1982 • 92 citations

Heat shock proteins in the nervous system

1994 • 91 citations

Two related localized mRNAs from Xenopus laevis encode ubiquitin-like fusion proteins

1993 • 86 citations

An enzyme with ubiquitin carboxy-terminal esterase activity from reticulocytes

1983 • 82 citations

E2/E3-mediated Assembly of Lysine 29-linked Polyubiquitin Chains

1999 • 79 citations

A "housekeeping" gene on the X chromosome encodes a protein similar to ubiquitin.

1988 • 76 citations

Processing of Poly-ubiquitin in the Polyprotein of an RNA Virus

1993 • 75 citations

Binding Sites of Ubiquitin-Protein Ligase

1989 • 70 citations

Kinetic studies of isopeptidase T: modulation of peptidase activity by ubiquitin

1995 • 65 citations

Quantitation and immunocytochemical localization of ubiquitin conjugates within rat red and white skeletal muscles.

1988 • 64 citations

Cloning and Expression of a Yeast Ubiquitin-Protein Cleaving Activity in Escherichia Coli

1989 • 59 citations

Genomic structure and expression of the human fau gene: Encoding the ribosomal protein S30 fused to a ubiquitin-like protein

1992 • 58 citations

Protein A24 lyase activity in nucleoli of thioacetamide-treated rat liver releases histone 2A and ubiquitin from conjugated protein A24

1981 • 57 citations

The MurineDUB-1Gene Is Specifically Induced by the βc Subunit of the Interleukin-3 Receptor

1996 • 54 citations

The Dose of a Putative Ubiquitin-Specific Protease Affects Position-Effect Variegation in Drosophila melanogaster

1996 • 51 citations

Recognition of Modified Forms of Ribonuclease A by the Ubiquitin System

1989 • 50 citations

A human de‐ubiquitinating enzyme with both isopeptidase and peptidase activities in vitro

1995 • 47 citations

Functional Characterization of the Ubiquitin Variant Encoded by the Baculovirus Autographa californica

1996 • 45 citations

Ubiquitin-like moiety of the monoclonal nonspecific suppressor factor beta is responsible for its activity.

1996 • 43 citations

The carboxyl extension of a ubiquitin-like protein is rat ribosomal protein S30.

1993 • 42 citations

The binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3

1999 • 40 citations

Coordinating DNA Replication To Produce One Copy of the Genome Requires Genes That Act in Ubiquitin Metabolism

1996 • 36 citations

Kinetic Studies on the Inhibition of Isopeptidase T by Ubiquitin Aldehyde

1996 • 32 citations

Cloning and Analysis of Expression of a Ubiquitin Carboxyl Terminal Hydrolase Expressed during Oogenesis in Drosophila melanogaster

1993 • 32 citations

Protein A24 lyase is an isopeptidase

1981 • 32 citations

Differential Effects of Ubiquitin Aldehyde on Ubiquitin and ATP-Dependent Protein Degradation

1996 • 32 citations

Polyubiquitin in crustacean striated muscle: increased expression and conjugation during molt-induced claw muscle atrophy

1995 • 31 citations

Dynamics of Ubiquitin Conjugation during Erythroid Differentiation in Vitro

1995 • 28 citations

Purification and Structural Properties of Ubiquitin

1988 • 28 citations

Purification of a ubiquitin protein peptidase from yeast with efficient in vitro assays

1989 • 26 citations

The Yeast UBC4 Ubiquitin Conjugating Enzyme Monoubiquitinates Itself in Vivo: Evidence for an E2-E2 Homointeraction

1995 • 25 citations

The structures of ubiquitin conjugates of yeast Iso-2-cytochrome c

1991 • 25 citations

Role of ubiquitin conformations in the specificity of protein degradation: Iodinated derivatives with altered conformations and activities

1986 • 24 citations

Affinity chromatography using protein immobilized via arginine residues: purification of ubiquitin carboxyl-terminal hydrolases

1989 • 15 citations

Ubiquitin Carboxyl-Terminal Hydrolases

1988 • 15 citations

Neuronal protein gene product 9.5 (IEF SSP 6104) is expressed in cultured human MRC‐5 fibroblasts of normal origin and is strongly down‐regulated in their SV40 transformed counterparts

1991 • 14 citations

Ubiquitin‐protein conjugates selectively distribute during early chicken embryogenesis

1995 • 14 citations

Amyloid beta precursor protein and ubiquitin epitopes in human and experimental dystrophic axons. Ultrastructural localization.

1994 • 12 citations

Ubiquitin C-terminal hydrolase as a putative factor involved in sex differentiation of fish (temperate wrasse, Halichoeres poecilopterus)

1994 • 10 citations

Distribution of prosome proteins and their relationship with the cytoskeleton in oogenesis of Xenopus laevis

1994 • 9 citations

Hrap12, a human ubiquitin-like nuclear protein that associates with human rad51/rad52 proteins

1996 • 1 citations