[32] Families of cysteine peptidases

CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP

1985 • 39,646 citations

Confidence Limits on Phylogenies: An Approach Using the Bootstrap

1985 • 18,213 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

1982 • 1,024 citations

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

1992 • 981 citations

The Neuron-Specific Protein PGP 9.5 Is a Ubiquitin Carboxyl-Terminal Hydrolase

1989 • 864 citations

The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.

1991 • 595 citations

Structure of papain refined at 1.65 Å resolution

1984 • 508 citations

Sequence analysis of cDNA coding for a major house dust mite allergen, Der p 1. Homology with cysteine proteases.

1988 • 469 citations

VIRAL PROTEINASES

1988 • 448 citations

Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications.

1988 • 428 citations

A second hepatitis C virus-encoded proteinase.

1993 • 416 citations

Specificity of Proteolysis

1992 • 398 citations

The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene

1993 • 379 citations

Two distinct gene subfamilies within the family of cysteine protease genes.

1993 • 354 citations

Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases

1994 • 308 citations

Structure of actinidin, after refinement at 1.7 Å resolution

1980 • 287 citations

A single bifunctional enzyme, PilD, catalyzes cleavage and N-methylation of proteins belonging to the type IV pilin family.

1993 • 255 citations

Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family

1992 • 250 citations

Product of the Pseudomonas aeruginosa gene pilD is a prepilin leader peptidase.

1991 • 231 citations

Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes.

1987 • 189 citations

The Two Cysteine Endopeptidases of Legume Seeds: Purification and Characterization by Use of Specific Fluorometric Assays

1993 • 180 citations

Cloning and functional analysis of the ubiquitin-specific protease gene UBP1 of Saccharomyces cerevisiae

1991 • 161 citations

Three-dimensional solution structure of the reduced form of Escherichia coli thioredoxin determined by nuclear magnetic resonance spectroscopy

1990 • 160 citations

Characterization of the catalytic residues of the tobacco etch virus 49-kDa proteinase

1989 • 150 citations

Amino acid substitutions in pilin of Pseudomonas aeruginosa. Effect on leader peptide cleavage, amino-terminal methylation, and pilus assembly

1991 • 147 citations

Stem bromelain: Amino acid sequence and implications for weak binding of cystatin

1989 • 141 citations

Identification of essential residues in potyvirus proteinase HC-pro by site-directed mutagenesis

1989 • 140 citations

The VPg of tobacco etch virus RNA is the 49-kDa proteinase or the N-terminal 24-kDa part of the proteinase

1990 • 138 citations

Cysteinyl Proteinases and Their Selective Inactivation

1990 • 136 citations

Detection, resolution and nomenclature of multiple ubiquitin carboxyl-terminal esterases from bovine calf thymus

1989 • 129 citations

Identification of the active site residues in the nsP2 proteinase of sindbis virus

1992 • 124 citations

Identification of the catalytic sites of a papain-like cysteine proteinase of murine coronavirus

1993 • 107 citations

Processing of TCP pilin by TcpJ typifies a common step intrinsic to a newly recognized pathway of extracellular protein secretion by gram-negative bacteria.

1991 • 103 citations

Mechanism of ubiquitin carboxyl-terminal hydrolase. Borohydride and hydroxylamine inactivate in the presence of ubiquitin.

1986 • 102 citations

Protein degradation by the phosphoinositide-specific phospholipase C-alpha family from rat liver endoplasmic reticulum.

1992 • 100 citations

Identification of a domain required for autoproteolytic cleavage of murine coronavirus gene A polyprotein

1989 • 99 citations

The autocatalytic protease p29 encoded by a hypovirulence-associated virus of the chestnut blight fungus resembles the potyvirus-encoded protease HC-Pro

1991 • 92 citations

Molecular cloning and analysis of small optic lobes, a structural brain gene of Drosophila melanogaster.

1991 • 88 citations

[10] Finding protein coding regions in genomic sequences

1990 • 84 citations

Specificity of proteolysis

1993 • 83 citations

Proteolytic processing of the cardioviral P2 region: Primary 2A/2B cleavage in clone-derived precursors

1992 • 83 citations

Cotranslational autoproteolysis involved in gene expression from a double-stranded RNA genetic element associated with hypovirulence of the chestnut blight fungus.

1991 • 80 citations

BLH1 codes for a yeast thiol aminopeptidase, the equivalent of mammalian bleomycin hydrolase.

1993 • 80 citations

Cloning and gene expression of Schistosoma mansoni protease.

1987 • 70 citations

Novel structures CTLA‐2α and CTLA‐2β expressed in mouse activated T cells and mast cells and homologous to cysteine proteinase proregions

1989 • 70 citations

Gene expression by a hypovirulence-associated virus of the chestnut blight fungus involves two papain-like protease activities. Essential residues and cleavage site requirements for p48 autoproteolysis.

1991 • 68 citations

Synthesis and characterization of ubiquitin ethyl ester, a new substrate for ubiquitin carboxyl-terminal hydrolase

1986 • 60 citations

Mutational analysis of the putative catalytic triad of the cowpea mosaic virus 24K protease

1991 • 59 citations

Cloning and Expression of a Yeast Ubiquitin-Protein Cleaving Activity in Escherichia Coli

1989 • 59 citations

Proteinase from germinating bean cotyledons. Evidence for involvement of a thiol group in catalysis

1984 • 58 citations

Poliovirus thiol proteinase 3C can utilize a serine nucleophile within the putative catalytic triad.

1991 • 58 citations

Primary structure of streptococcal proteinase. III. Isolation of cyanogen bromide peptides: complete covalent structure of the polypeptide chain.

1976 • 57 citations

Identification of active-site cysteines in the conserved domain of PilD, the bifunctional type IV pilin leader peptidase/N-methyltransferase of Pseudomonas aeruginosa

1993 • 55 citations

Isolation and characterization of the Porphyromonas gingivalis prtT gene, coding for protease activity

1993 • 52 citations

The BaculovirusAutographa californicaNuclear Polyhedrosis Virus Genome Includes a Papain-Like Sequence

1992 • 48 citations

Expression and partial characterization of a cathepsin B-like enzyme (Sm31) and a proposed ‘haemoglobinase’ (Sm32) from Schistosoma mansoni

1993 • 48 citations

Identification of the Essential Cysteine and Histidine Residues of the Turnip Yellow Mosaic Virus Protease

1994 • 47 citations

Molecular cloning of three cDNAs that encode cysteine proteinases in the digestive gland of the American lobster (Homarus americanus)

1991 • 47 citations

Protease of adenovirus type 2: Partial characterization

1979 • 45 citations

Purification, characterization, and amino acid composition of rabbit pulmonary bleomycin hydrolase

1987 • 45 citations

Kinetics and sequence specificity of processing of prepilin by PilD, the type IV leader peptidase of Pseudomonas aeruginosa

1992 • 44 citations

Pyroglutamyl Peptidase Gene from Bacillus amyloliquefaciens: Cloning, Sequencing, Expression, and Crystallization of the Expressed Enzyme1

1993 • 38 citations

Crystal and molecular structure of the sulfhydryl protease calotropin DI at 3·2 Å resolution

1982 • 38 citations

Clostripain: Characterization of the active site

1991 • 35 citations

The heterodimeric protease clostripain from Clostridium histolyticum is encoded by a single gene

1993 • 31 citations

Cleavage specificity of the poliovirus 3C protease is not restricted to Gln-Gly at the 3C/3D junction

1990 • 29 citations

The active adenovirus protease is the intact L3 23K protein

1993 • 27 citations

Mechanism of action of streptococcal proteinase. II. Comparison of the kinetics of protein ase- and papain-catalyzed hydrolysis of N-acylamino acid esters

1973 • 26 citations

Comparisons of the genomic sequences of erysimum latent virus and other tymoviruses: a search for the molecular basis of their host specificities

1992 • 24 citations

Amino‐Acid Sequences of the Active‐Site Sulfhydryl Peptide and Other Thiol Peptides from the Cysteine Proteinase α‐Clostripain

1983 • 23 citations

Primary structure of zymogen of streptococcal proteinase

1982 • 19 citations

N-α-carbobenzoxy pyroglutamyl diazomethyl ketone as active-site-directed inhibitor for pyroglutamyl peptidase

1982 • 15 citations

Autocatalytic activity of the tobacco etch virus NIa proteinase in viral and foreign protein sequences

1992 • 13 citations

Site-directed mutagenesis of the putative active site residues of 3C proteinase of coxsackievirus B3: evidence of a functional relationship with trypsin-like serine proteinases

1993 • 10 citations

Expression of the “helper component” protein of potato virus Y (PVY) inE. coli: Possible involvement of a third protease

1993 • 3 citations