Cytokine function of heat shock proteins

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

Toll-like receptors and innate immunity

2001 • 4,138 citations

Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein

2002 • 3,280 citations

A family of human receptors structurally related to Drosophila Toll

1998 • 1,735 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

2000 • 1,594 citations

Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)

1999 • 1,570 citations

MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways

1998 • 1,565 citations

Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-like Receptor-2

1999 • 1,500 citations

Novel Signal Transduction Pathway Utilized by Extracellular HSP70

2002 • 1,483 citations

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway

2000 • 1,299 citations

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

1998 • 1,218 citations

Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2

2000 • 1,173 citations

CD91 Is a Common Receptor for Heat Shock Proteins gp96, hsp90, hsp70, and Calreticulin

2001 • 1,118 citations

Chaperone-Mediated Protein Folding

1999 • 1,043 citations

Roles of heat-shock proteins in innate and adaptive immunity

2002 • 1,037 citations

HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway

2002 • 949 citations

Endocytosed HSP60s Use Toll-like Receptor 2 (TLR2) and TLR4 to Activate the Toll/Interleukin-1 Receptor Signaling Pathway in Innate Immune Cells

2001 • 800 citations

Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide

1998 • 778 citations

Tlr4: central component of the sole mammalian LPS sensor

2000 • 764 citations

The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage.

1988 • 654 citations

The Human Toll Signaling Pathway: Divergence of Nuclear Factor κB and JNK/SAPK Activation Upstream of Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6)

1998 • 581 citations

Heat shock proteins transfer peptides during antigen processing and CTL priming

1994 • 580 citations

Heat-shock proteins as activators of the innate immune system

2002 • 579 citations

Cutting Edge: Heat Shock Protein (HSP) 60 Activates the Innate Immune Response: CD14 Is an Essential Receptor for HSP60 Activation of Mononuclear Cells

2000 • 561 citations

Heat Shock Proteins Come of Age: Primitive Functions Acquire New Roles in an Adaptive World

1998 • 560 citations

Chlamydial Heat Shock Protein 60 Localizes in Human Atheroma and Regulates Macrophage Tumor Necrosis Factor-α and Matrix Metalloproteinase Expression

1998 • 546 citations

Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages

1999 • 517 citations

The Endoplasmic Reticulum-resident Heat Shock Protein Gp96 Activates Dendritic Cells via the Toll-like Receptor 2/4 Pathway

2002 • 496 citations

Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses

2002 • 495 citations

Heat shock proteins as cellular lifeguards

1999 • 492 citations

Human 60-kDa Heat-Shock Protein: A Danger Signal to the Innate Immune System

1999 • 474 citations

Tumor rejection antigens of chemically induced sarcomas of inbred mice.

1986 • 463 citations

Serum Soluble Heat Shock Protein 60 Is Elevated in Subjects With Atherosclerosis in a General Population

2000 • 437 citations

A CD14-independent LPS receptor cluster

2001 • 422 citations

Chlamydial Heat Shock Protein 60 Activates Macrophages and Endothelial Cells Through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway

2002 • 416 citations

Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70.

1994 • 411 citations

Endotoxin Contamination in Recombinant Human Heat Shock Protein 70 (Hsp70) Preparation Is Responsible for the Induction of Tumor Necrosis Factor α Release by Murine Macrophages

2002 • 399 citations

Selective release from cultured mammalian cells of heat‐shock (stress) proteins that resemble glia‐axon transfer proteins

1989 • 389 citations

Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.

1991 • 384 citations

Heat Shock Proteins and Cardiovascular Pathophysiology

2001 • 377 citations

The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor

2000 • 375 citations

Inflammatory Response After Open Heart Surgery

2002 • 362 citations

Toll-Like Receptor 4, But Not Toll-Like Receptor 2, Is a Signaling Receptor forEscherichiaandSalmonellaLipopolysaccharides

2000 • 352 citations

Role of Heat Shock Proteins in Atherosclerosis

2002 • 350 citations

SYNOVIAL FLUID T CELL REACTIVITY AGAINST 65 kD HEAT SHOCK PROTEIN OF MYCOBACTERIA IN EARLY CHRONIC ARTHRITIS

1988 • 311 citations

Roles of heat-shock proteins in antigen presentation and cross-presentation

2002 • 300 citations

Stimulation of Th1-Polarizing Cytokines, C-C Chemokines, Maturation of Dendritic Cells, and Adjuvant Function by the Peptide Binding Fragment of Heat Shock Protein 70

2002 • 267 citations

Heat Shock Proteins, Inflammation, and Cardiovascular Disease

2002 • 261 citations

Primary Tumor Tissue Lysates Are Enriched in Heat Shock Proteins and Induce the Maturation of Human Dendritic Cells

2001 • 260 citations

Purification and Identification of Secreted Oxidative Stress-induced Factors from Vascular Smooth Muscle Cells

2000 • 259 citations

Heat Shock Proteins gp96 and hsp70 Activate the Release of Nitric Oxide by APCs

2002 • 258 citations

Circulating Heat Shock Protein 60 Is Associated With Early Cardiovascular Disease

2000 • 255 citations

Endotoxin-free heat-shock protein 70 fails to induce APC activation

2002 • 244 citations

Isolation of MHC Class I-Restricted Tumor Antigen Peptide and Its Precursors Associated with Heat Shock Proteins hsp70, hsp90, and gp96

1999 • 239 citations

Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines.

1996 • 237 citations

Human Heat Shock Protein 60 Induces Maturation of Dendritic Cells Versus a Th1-Promoting Phenotype

2003 • 226 citations

Mechanisms of stimulation of interleukin-1 beta and tumor necrosis factor-alpha by Mycobacterium tuberculosis components.

1993 • 224 citations

Recombinant Human Heat Shock Protein 60 Does Not Induce the Release of Tumor Necrosis Factor α from Murine Macrophages

2003 • 223 citations

Eukaryotic chaperonin CCT stabilizes actin and tubulin folding intermediates in open quasi-native conformations

2000 • 217 citations

Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide

1999 • 202 citations

The Receptor for Heat Shock Protein 60 on Macrophages Is Saturable, Specific, and Distinct from Receptors for Other Heat Shock Proteins

2002 • 198 citations

Identification of human heat shock protein 60 (Hsp60) and anti-Hsp60 antibodies in the peripheral circulation of normal individuals

1999 • 187 citations

Serum heat shock protein and anti-heat shock protein antibody levels in aging

2001 • 168 citations

Bacterial heat shock proteins directly induce cytokine mRNA and interleukin-1 secretion in macrophage cultures

1994 • 166 citations

Different Efficiency of Heat Shock Proteins (HSP) to Activate Human Monocytes and Dendritic Cells: Superiority of HSP60

2002 • 163 citations

Mycobacterial 65-kD heat shock protein induces release of proinflammatory cytokines from human monocytic cells

1993 • 162 citations

HSP70 peptide-bearing and peptide-negative preparations act as chaperokines

2000 • 159 citations

Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophages

2001 • 152 citations

Evaluation of CD14 in host defence

2000 • 139 citations

Immune Response against Heat Shock Proteins in Infectious Diseases

1999 • 136 citations

T Cell Proliferative Responses of Type 1 Diabetes Patients and Healthy Individuals to Human hsp60 and its Peptides

1999 • 135 citations

Cytokine and adhesion molecule expression in human monocytes and endothelial cells stimulated with bacterial heat shock proteins

1997 • 133 citations

Two Lipoproteins Extracted fromEscherichia coliK-12 LCD25 Lipopolysaccharide Are the Major Components Responsible for Toll-Like Receptor 2-Mediated Signaling

2002 • 127 citations

Stress-induced release of HSC70 from human tumors

2003 • 121 citations

Re-evaluating the role of heat-shock protein–peptide interactions in tumour immunity

2003 • 112 citations

The effect of nucleotides and mitochondrial chaperonin 10 on the structure and chaperone activity of mitochondrial chaperonin 60

2001 • 112 citations

GRP94/gp96 Elicits ERK Activation in Murine Macrophages

2003 • 107 citations

Heat shock proteins in health and disease: therapeutic targets or therapeutic agents?

2001 • 102 citations

Role of hsp60 during Autoimmune and Bacterial Inflammation

1991 • 98 citations

Diagnosis and nonsurgical management of osteoarthritis

2001 • 97 citations

Type I chaperonins: not all are created equal

2002 • 81 citations

Mycobacterial Heat‐Shock Protein 65 Induces Proinflammatory Cytokines but does not Activate Human Mononuclear Phagocytes

1994 • 74 citations

Activation of Synovial Fluid T Lymphocytes by 60‐Kd Heat‐Shock Proteins in Patients with Inflammatory synovitis

1992 • 54 citations

Molecular chaperones and the heat shock response at Cold Spring Harbor

1997 • 50 citations

Legionella pneumophila heat‐shock protein‐induced increase of interleukin‐1β mRNA involves protein kinase C signalling in macrophages

1996 • 47 citations

Mycobacterial 65-kilodalton heat shock protein induces tumor necrosis factor alpha and interleukin 6, reactive nitrogen intermediates, and toxoplasmastatic activity in murine peritoneal macrophages

1995 • 47 citations

Infections, heat shock proteins, and atherosclerosis

2003 • 41 citations

Adjuvants for vaccines, a quest

2003 • 37 citations

Structure/Function Relationships of CD14

1999 • 33 citations

Evidence for T lymphocyte reactivity to the 65 kilodalton heat shock protein of mycobacterium in active Crohn's disease.

1992 • 22 citations

The immunosuppressive activity of chemically modified lipopolysaccharide of Shigella sonnei

2002 • 7 citations