Evaluation of CD14 in host defence

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

1999 • 3,364 citations

Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction

1999 • 1,905 citations

A family of human receptors structurally related to Drosophila Toll

1998 • 1,735 citations

Structure and Function of Lipopolysaccharide Binding Protein

1990 • 1,689 citations

Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)

1999 • 1,570 citations

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

1998 • 1,218 citations

Sepsis: A New Hypothesis for Pathogenesis of the Disease Process

1997 • 1,014 citations

GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases

1991 • 848 citations

Endotoxin signal transduction in macrophages

1996 • 803 citations

Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide

1998 • 778 citations

Regulated internalization of caveolae.

1994 • 760 citations

Resistance to Endotoxin Shock and Reduced Dissemination of Gram-Negative Bacteria in CD14-Deficient Mice

1996 • 760 citations

Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14.

1994 • 747 citations

CD14 Is a pattern recognition receptor

1994 • 706 citations

Human CD14 mediates recognition and phagocytosis of apoptotic cells

1998 • 685 citations

The Toll-receptor family and control of innate immunity

1999 • 666 citations

The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage.

1988 • 654 citations

Bacterial Lipopolysaccharide Activates Nuclear Factor-κB through Interleukin-1 Signaling Mediators in Cultured Human Dermal Endothelial Cells and Mononuclear Phagocytes

1999 • 610 citations

CD14: Cell surface receptor and differentiation marker

1993 • 600 citations

Recognition of Gram-negative bacteria and endotoxin by the innate immune system

1999 • 577 citations

LPS-binding proteins and receptors

1998 • 480 citations

The novel subset of CD14+/CD16+ blood monocytes is expanded in sepsis patients

1993 • 467 citations

Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes.

1991 • 427 citations

Elevated soluble CD14 receptors and altered cytokines in chronic heart failure

1997 • 393 citations

Genetic and Physical Mapping of theLpsLocus: Identification of the Toll-4 Receptor as a Candidate Gene in the Critical Region

1998 • 372 citations

LPS-binding protein protects mice from septic shock caused by LPS or gram-negative bacteria.

1998 • 346 citations

Lipopolysaccharide Binding Protein-mediated Complexation of Lipopolysaccharide with Soluble CD14

1995 • 331 citations

Nuclear factor k B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy

1998 • 306 citations

GPI-microdomains: a role in signalling via immunoreceptors

1999 • 270 citations

Soluble CD14 acts as a shuttle in the neutralization of lipopolysaccharide (LPS) by LPS-binding protein and reconstituted high density lipoprotein.

1995 • 268 citations

Binding of Bacterial Peptidoglycan to CD14

1998 • 265 citations

MCP-1 protects mice in lethal endotoxemia.

1997 • 262 citations

Lipopolysaccharide (LPS) Signal Transduction and Clearance

1995 • 260 citations

Mechanism of Gram-positive Shock: Identification of Peptidoglycan and Lipoteichoic Acid Moieties Essential in the Induction of Nitric Oxide Synthase, Shock, and Multiple Organ Failure

1998 • 237 citations

Lipopolysaccharide binding protein and soluble CD14 catalyze exchange of phospholipids.

1997 • 232 citations

Human monocyte CD14 is upregulated by lipopolysaccharide

1996 • 227 citations

CD14 Is a Cell-activating Receptor for Bacterial Peptidoglycan

1996 • 222 citations

Transgenic mice expressing human CD14 are hypersensitive to lipopolysaccharide.

1993 • 213 citations

Increased Circulating Soluble Cd14 Is Associated With High Mortality In Gram-Negative Septic Shock

1995 • 206 citations

The involvement of CD14 in stimulation of cytokine production by uronic acid polymers

1993 • 205 citations

Treponema pallidumandBorrelia burgdorferiLipoproteins and Synthetic Lipopeptides Activate Monocytic Cells via a CD14-Dependent Pathway Distinct from That Used by Lipopolysaccharide

1998 • 201 citations

Physiologic relevance of the membrane attack complex inhibitory protein CD59 in human seminal plasma: CD59 is present on extracellular organelles (prostasomes), binds cell membranes, and inhibits complement-mediated lysis.

1993 • 196 citations

Tolerance to endotoxin-induced expression of the interleukin-1 beta gene in blood neutrophils of humans with the sepsis syndrome.

1993 • 192 citations

Antimicrobial polypeptides of human neutrophils

1990 • 188 citations

Isolation and phenotypic characterization of colonic macrophages

1998 • 184 citations

Glycosyl-phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin.

1993 • 183 citations

Targeted Deletion of the Lipopolysaccharide (LPS)-binding Protein Gene Leads to Profound Suppression of LPS Responses Ex Vivo, whereas In Vivo Responses Remain Intact

1997 • 179 citations

Quantitation of surface CD14 on human monocytes and neutrophils

1997 • 168 citations

Elevated Levels of Serum-Soluble CD14 in Human Immunodeficiency Virus Type 1 (HIV-1) Infection: Correlation to Disease Progression and Clinical Events

1998 • 166 citations

Activation of human monocytes by streptococcal rhamnose glucose polymers is mediated by CD14 antigen, and mannan binding protein inhibits TNF-alpha release.

1995 • 164 citations

Relationship between soluble CD14, lipopolysaccharide binding protein, and the alveolar inflammatory response in patients with acute respiratory distress syndrome.

1997 • 164 citations

Interleukin-10 Inhibits Activation of Coagulation and Fibrinolysis During Human Endotoxemia

1997 • 156 citations

Selective depletion of CD14+ CD16+ monocytes by glucocorticoid therapy

1998 • 150 citations

Evidence for a CD14+ population of monocytes in inflammatory bowel disease mucosa—implications for pathogenesis

1995 • 145 citations

Monocytes can phagocytose Gram-negative bacteria by a CD14-dependent mechanism.

1996 • 144 citations

Analysis of lipopolysaccharide binding by CD14.

1993 • 143 citations

Enzymatically Deacylated Lipopolysaccharide (LPS) Can Antagonize LPS at Multiple Sites in the LPS Recognition Pathway

1995 • 143 citations

Serum CD14 levels in poly traumatized and severely burned patients

1991 • 143 citations

Caveolae, transmembrane signalling and cellular transformation

1995 • 139 citations

CD14-Dependent Internalization of Bacterial Lipopolysaccharide (LPS) Is Strongly Influenced by LPS Aggregation But Not by Cellular Responses to LPS

1998 • 136 citations

Biochemistry and expression of myelomonocytic antigens.

1986 • 129 citations

Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endotoxin signaling system.

1996 • 128 citations

Soluble lipopolysaccharide receptor (CD14) is released via two different mechanisms from human monocytes and CD14 transfectants

1995 • 126 citations

Quantitative analysis of leukocyte membrane antigen expression: Normal adult values

1996 • 124 citations

Endotoxin activates human vascular smooth muscle cells despite lack of expression of CD14 mRNA or endogenous membrane CD14

1995 • 124 citations

Regulation of human monocyte apoptosis by the CD14 molecule.

1997 • 115 citations

Elevated levels of soluble CD 14 in serum of patients with systemic lupus erythematosus

1994 • 113 citations

Binding sites for endotoxins (lipopolysaccharides) on human monocytes.

1991 • 113 citations

The Monoclonal Antimonocyte Antibody My4 Stains B Lymphocytes and Two Distinct Monocyte Subsets in Human Peripheral Blood

1988 • 109 citations

CD14 contributes to the adherence of human monocytes to cytokine-stimulated endothelial cells.

1991 • 108 citations

Release from a human monocyte‐like cell line of two different soluble forms of the lipopolysaccharide receptor, CD14

1993 • 108 citations

CD14-dependent Endotoxin Internalization via a Macropinocytic Pathway

1998 • 107 citations

Nucleotide sequence of the gene encoding the monocyte differentiation antigen, CD14

1988 • 101 citations

Lipopolysaccharide induces up‐regulation of CD14 molecule on monocytes in human whole blood

1992 • 100 citations

Characterization of binding and TNF-α-inducing ability of chitosans on monocytes: the involvement of CD14

1994 • 99 citations

Phosphatidylinositides Bind to Plasma Membrane CD14 and Can Prevent Monocyte Activation by Bacterial Lipopolysaccharide

1998 • 94 citations

Does endotoxin stimulate cells by mimicking ceramide?

1995 • 93 citations

IL-13 down-regulates CD14 expression and TNF-alpha secretion in normal human monocytes.

1995 • 90 citations

Heterogeneous Expression and Release of CD14 by Human Gingival Fibroblasts: Characterization and CD14-Mediated Interleukin-8 Secretion in Response to Lipopolysaccharide

1998 • 89 citations

CD 14⁺⁺Monocytes, CD14⁺/CD16⁺Subset and Soluble CD14 as Biological Markers of Inflammatory Systemic Diseases and Monitoring Immuno-suppressive Therapy

1999 • 85 citations

IL-4 Decreases the Expression of the Monocyte Differentiation Marker CD14, Paralleled by an Increasing Accessory Potency

1991 • 85 citations

Mutation of Amino Acids 39–44 of Human CD14 Abrogates Binding of Lipopolysaccharide and Escherichia coli

1997 • 83 citations

Potential role of membrane internalization and vesicle fusion in adhesion of neutrophils in response to lipopolysaccharide and TNF.

1996 • 82 citations

Lipopolysaccharide induces apoptosis in a bovine endothelial cell line via a soluble CD14 dependent pathway

1998 • 79 citations

Tolerance to Pyrogens

1998 • 78 citations

CD14 and tolerance to lipopolysaccharide: biochemical and functional analysis.

1993 • 78 citations

Endotoxin receptors (CD14) are found with CD16 (Fc gamma RIII) in an intracellular compartment of neutrophils that contains alkaline phosphatase.

1995 • 78 citations

Engagement of the monocyte surface antigen CD14 induces lymphocyte function-associated antigen-1/intercellular adhesion molecule-1-dependent homotypic adhesion.

1990 • 76 citations

Soluble CD14 but not interleukin-6 is a new marker for clinical activity in atopic dermatitis

1992 • 76 citations

Dual effects of soluble CD14 on LPS priming of neutrophils

1997 • 75 citations

Obtention and characterization of primary astrocyte and microglial cultures from adult monkey brains

1997 • 74 citations

Effect of cytokines and lipopolysaccharide on CD14 antigen expression in human monocytes and macrophages

1991 • 73 citations

Endotoxin opens the Toll gates to innate immunity

1999 • 72 citations

Expansion of CD14+CD16+ monocytes in critically ill cardiac surgery patients.

1998 • 71 citations

Detection and biochemical characteristics of the receptor for complexes of soluble CD14 and bacterial lipopolysaccharide.

1997 • 66 citations

Coexistence of CD14-dependent and independent pathways for stimulation of human monocytes by gram-positive bacteria

1997 • 64 citations

Endotoxin Binding and Elimination by Monocytes: Secretion of Soluble CD14 Represents an Inducible Mechanism Counteracting Reduced Expression of Membrane CD14 in Patients with Sepsis and in a Patient with Paroxysmal Nocturnal Hemoglobinuria

1998 • 63 citations

Signal Transduction in LPS-Activated Aged and Young Monocytes

1998 • 62 citations

Saturable CD14-dependent binding of fluorescein-labeled lipopolysaccharide to human monocytes

1997 • 60 citations

Role for L-selectin in lipopolysaccharide-induced activation of neutrophils

1996 • 57 citations

Increased in vitro production and serum levels of the soluble lipopolysaccharide receptor sCD14 in liver disease

1995 • 57 citations

Expression and release of the monocyte lipopolysaccharide receptor antigen CD14 are suppressed by glucocorticoids in vivo and in vitro.

1997 • 54 citations

T-Lymphozyten und Monozyten in der Pathogenese der Arteriosklerose

1998 • 51 citations

Serum Concentrations of Lipopolysaccharide Activity–Modulating Proteins during Tuberculosis

1998 • 50 citations

Engagement of CD14 on human monocytes terminates T cell proliferation by delivering a negative signal to T cells.

1991 • 48 citations

Identification of CD14 residues involved in specific lipopolysaccharide recognition

1997 • 45 citations

Pathological significance of elevated soluble CD14 production in rheumatoid arthritis: in the presence of soluble CD14, lipopolysaccharides at low concentrations activate RA synovial fibroblasts

1998 • 41 citations

Soluble CD14 is increased in bronchoalveolar lavage of active sarcoidosis and correlates with alveolar macrophage membrane-bound CD14.

1995 • 40 citations

Sensitive responses of leukocytes to lipopolysaccharide require a protein distinct from CD14 at the cell surface.

1997 • 40 citations

Azurophilic granules of human neutrophils contain CD14

1997 • 37 citations

Elevated levels of soluble CD14 in serum of patients with acute Plasmodium falciparum malaria

1996 • 36 citations

Functional role of endogenous CD14 in lipopolysaccharide-stimulated bone resorption

1997 • 33 citations

Difference in the blood monocyte phenotype between uremic patients and healthy controls: its relation to monocyte differentiation into macrophages in the peritoneal cavity.

1998 • 31 citations

Chorioamnionitis reduces placental endocrine functions: the role of bacterial lipopolysaccharide and superoxide anion

1997 • 31 citations

EFFECT OF RECOMBINANT INTERLEUKIN-1β ON MURINE CD14 GENE EXPRESSION IN VIVO

1998 • 30 citations

Soluble (s) CD14 and Plasmatic Lipopolysaccharides (LPS) in Patients with Chronic Hepatitis C Before and After Treatment with Interferon (IFN)-α

1998 • 29 citations

Porphyromonas gingivalis lipopolysaccharide-stimulated bone resorption via CD14 is inhibited by broad-spectrum antibiotics

1997 • 29 citations

Neutrophil response to endotoxin in the adult respiratory distress syndrome: role of CD14.

1995 • 28 citations

Molecular Basis of Endotoxin Tolerancea

1998 • 27 citations

Variation of LPS-binding capacity, epitope expression, and shedding of membrane-bound CD14 during differentiation of human monocytes.

1995 • 27 citations

Human breast cancer cells share antigens with the myeloid monocyte lineage

1987 • 23 citations

Transforming Growth Factor-β1 Lowers the CD14 Content of Monocytes

1994 • 22 citations

CD14 and CD11b mediate serum-independent binding to human monocytes of an acylpolygalactoside isolated from Klebsiella pneumoniae

1994 • 20 citations

Soluble CD14 Monocyte Antigen in Suction Blister Fluid and Serum of Patients with Psoriasis

1993 • 20 citations

Human macrophages respond to LPS in a serum-independent, CD14-dependent manner

1996 • 18 citations

Immunomodulating Properties of the Antibiotic Novobiocin in Human Monocytes

1998 • 16 citations

Lipopolysaccharide Primes Human Basophils for Enhanced Mediator Release: Requirement for Plasma Co-factor and CD14

1994 • 15 citations

Role of cell surface molecules of Blastomyces dermatitidis in the pathogenesis and immunobiology of blastomycosis.

1997 • 11 citations

CD14-Dependent Activation of Human Endothelial Cells byBacteroides fragilisOuter Membrane

1998 • 8 citations