Genetic analysis of insulin signaling in Drosophila

Central nervous system control of food intake

2000 • 6,305 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

2001 • 1,583 citations

The renaissance of GSK3

2001 • 1,459 citations

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

2001 • 1,398 citations

Genetic pathways that regulate ageing in model organisms

2000 • 1,341 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control

2001 • 1,206 citations

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

1994 • 1,076 citations

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1998 • 969 citations

Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene

2001 • 908 citations

Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4

1999 • 838 citations

Drosophila S6 Kinase: A Regulator of Cell Size

1999 • 710 citations

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family

2001 • 637 citations

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

2000 • 615 citations

Stem Cells and Their Progeny Respond to Nutritional Changes during Drosophila Oogenesis

2001 • 605 citations

The Drosophila Tuberous Sclerosis Complex Gene Homologs Restrict Cell Growth and Cell Proliferation

2001 • 542 citations

The modular phosphorylation and activation of p70^s6k

1997 • 539 citations

Drosophila Tsc1 Functions with Tsc2 to Antagonize Insulin Signaling in Regulating Cell Growth, Cell Proliferation, and Organ Size

2001 • 511 citations

IRS-2 pathways integrate female reproduction and energy homeostasis

2000 • 459 citations

TOR signalling and control of cell growth

1997 • 458 citations

Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

2000 • 431 citations

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB

1999 • 368 citations

Identification of Tuberin, the Tuberous Sclerosis-2 Product. TUBERIN POSSESSES SPECIFIC Rap1GAP ACTIVITY

1995 • 361 citations

The Tuberous Sclerosis 2 Gene Product, Tuberin, Functions as a Rab5 GTPase Activating Protein (GAP) in Modulating Endocytosis

1997 • 353 citations

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

1999 • 349 citations

The Drosophila insulin receptor is required for normal growth.

1996 • 337 citations

The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.

1995 • 335 citations

Slow aging during insect reproductive diapause: why butterflies, grasshoppers and flies are like worms

2001 • 326 citations

Regulation of imaginal disc cell size, cell number and organ size by Drosophila class IA phosphoinositide 3-kinase and its adaptor

1999 • 299 citations

gigas, a Drosophila Homolog of Tuberous Sclerosis Gene Product-2, Regulates the Cell Cycle

1999 • 257 citations

The developing CNS: a scenario for the action of proinsulin, insulin and insulin-like growth factors

1995 • 243 citations

The Insulin Receptor and Its Cellular Targets¹

2001 • 231 citations

Minireview: Tissue-SpecificVersusGeneralized Gene Targeting of theigf1andigf1rGenes and Their Roles in Insulin-Like Growth Factor Physiology

2001 • 198 citations

The conserved PI3′K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila

2000 • 193 citations

Hormones in male sexual development

2000 • 185 citations

Localization of an insulin-like peptide in brains of two flies

2001 • 165 citations

Genetic analysis of protein kinase B (AKT) in Drosophila

1998 • 138 citations

Isolation of material displaying insulin-like immunological biological activity from the brain of the blowfly Calliphora vomitoria

1979 • 121 citations

Insulin is a Drosophila hormone and acts to enhance the differentiation of embryonic Drosophila cells

1974 • 102 citations

The Drosophila Insulin Receptor Contains a Novel Carboxyl-terminal Extension Likely to Play an Important Role in Signal Transduction

1995 • 98 citations

Structure and Lspecificity of the Drosophila melanogaster Insulin Receptor

1987 • 92 citations

The Drosophila Insulin Receptor Activates Multiple Signaling Pathways but Requires Insulin Receptor Substrate Proteins for DNA Synthesis

1996 • 88 citations

The Insulin Receptor and Its Cellular Targets

2001 • 88 citations

Tissue localization of Drosophila melanogaster insulin receptor transcripts during development.

1988 • 75 citations

The Drosophila insulin receptor is required for normal growth

1996 • 69 citations

Minireview: Tissue-Specific Versus Generalized Gene Targeting of the igf1 and igf1r Genes and Their Roles in Insulin-Like Growth Factor Physiology

2001 • 67 citations

Structure and ligand specificity of the Drosophila melanogaster insulin receptor.

1987 • 62 citations

Neurosecretory cells in insect brain and production of hypoglycaemic hormone

1975 • 55 citations

Characterization of Drosophila Insulin Receptor Substrate

2000 • 37 citations

Drosophila insulin receptor: lectin-binding properties and a role for oxidation-reduction of receptor thiols in activation.

1995 • 22 citations

The Carboxyl Terminal Extension of the Drosophila Insulin Receptor Homologue Binds IRS-1 and Influences Cell Survival

1999 • 21 citations

Intraportal hyperinsulinemia decreases insulin-stimulated glucose uptake in the dog

1990 • 19 citations

Structural and Functional Characterization of theDrosophilaGlycogen Phosphorylase Gene

1999 • 15 citations

The Dstpk61 locus of Drosophila produces multiple transcripts and protein isoforms, suggesting it is involved in multiple signalling pathways

2000 • 12 citations

Insulin receptor in Drosophila melanogaster

1986 • 9 citations

Drosophila insulin receptor: lectin-binding properties and a role for oxidation-reduction of receptor thiols in activation

1995 • 7 citations