The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

The insulin signaling system.

1994 • 1,733 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Insulin Action, Diabetogenes, and the Cause of Type II Diabetes

1994 • 914 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

The engrailed locus of drosophila: Structural analysis of an embryonic transcript

1985 • 735 citations

Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and in grasshopper embryos.

1982 • 733 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila.

1993 • 719 citations

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

1993 • 705 citations

SH2 and SH3 domains

1993 • 697 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

Phosphatidylinositol 3‐kinase

1994 • 649 citations

Eukaryotic start and stop translation sites

1991 • 602 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

Monoclonal antibodies against the Drosophila nervous system.

1982 • 534 citations

Regulation of signal transduction and signal diversity by receptor oligomerization

1994 • 485 citations

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.

1994 • 450 citations

Characterization and use of theDrosophilametallothionein promoter in culturedDrosophila melanogastercells

1988 • 440 citations

Analysis of subtelomeric heterochromatin in the Drosophila minichromosome Dp1187 by single P element insertional mutagenesis.

1992 • 403 citations

Splicing signals inDrosophila: intron size, information content, and consensus sequences

1992 • 380 citations

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1988 • 368 citations

The IRS-1 signaling system

1994 • 310 citations

The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling

1994 • 282 citations

RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila

1994 • 260 citations

Determination of Neuronal Cell Fate: Lessons from the R7 Neuron of Drosophila

1994 • 245 citations

A new Drosophila homeo box gene is expressed in mesodermal precursor cells of distinct muscles during embryogenesis.

1990 • 216 citations

Activation of p70/p85 S6 kinase by a pathway independent of p21fi ras

1994 • 207 citations

Analysis of the gene encoding the largest subunit of RNA polymerase II in Drosophila

1989 • 205 citations

A model for insulin binding to the insulin receptor

1994 • 199 citations

The fate of the CNS midline progenitors in Drosophila as revealed by a new method for single cell labelling

1994 • 190 citations

Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system.

1994 • 170 citations

Differentiation of 3T3-L1 Fibroblasts to Adipocytes Induced by Transfection of ras Oncogenes

1991 • 166 citations

Hierarchy of Binding Sites for Grb2 and Shc on the Epidermal Growth Factor Receptor

1994 • 159 citations

Neuroblast Specification and Formation Regulated by wingless in the Drosophila CNS

1993 • 157 citations

The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor

1994 • 155 citations

Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen.

1994 • 153 citations

Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors.

1991 • 146 citations

Localized expression of sloppy paired protein maintains the polarity of Drosophila parasegments.

1994 • 139 citations

A common precursor for glia and neurons in the embryonic CNS ofDrosophilagives rise to segment-specific lineage variants

1993 • 133 citations

Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody.

1986 • 123 citations

Mitogen-activated protein kinase activation is not sufficient for stimulation of glucose transport or glycogen synthase in 3T3-L1 adipocytes.

1993 • 119 citations

Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.

1994 • 116 citations

Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase.

1992 • 115 citations

The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies.

1992 • 107 citations

The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals.

1992 • 105 citations

spitz, a Drosophila homolog of transforming growth factor-α, is required in the founding photoreceptor cells of the compound eye facets

1994 • 100 citations

Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila.

1993 • 99 citations

Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes.

1993 • 98 citations

Nucleotide sequence and structure of the sevenless gene of Drosophila melanogaster.

1988 • 93 citations

Structure and Lspecificity of the Drosophila melanogaster Insulin Receptor

1987 • 92 citations

Drosophila PS2 integrin mediates RGD-dependent cell-matrix interactions

1992 • 85 citations

A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies.

1991 • 85 citations

Identification of determinants that confer ligand specificity on the insulin receptor.

1992 • 81 citations

Detection of a new hormone contact site within the insulin receptor ectodomain by the use of a novel photoreactive insulin.

1992 • 80 citations

Insulin signalling: the role of insulin receptor substrate 1

1994 • 76 citations

Tissue localization of Drosophila melanogaster insulin receptor transcripts during development.

1988 • 75 citations

Role of p21ras in insulin-stimulated glucose transport in 3T3-L1 adipocytes.

1994 • 73 citations

The torpedo (DER) receptor tyrosine kinase is required at multiple times during Drosophila embryogenesis

1992 • 73 citations

Activation of Ras by insulin in 3T3 L1 cells does not involve GTPase-activating protein phosphorylation.

1992 • 73 citations

Cloning of a drosophila cDNA encoding a polypeptide similar to the human insulin receptor precursor

1986 • 73 citations

Dissection of the faint little ball (fib) phenotype: determination of the development of the Drosophila central nervous system by early interactions in the ectoderm

1992 • 71 citations

The grasshopper median neuroblast is a multipotent progenitor cell that generates glia and neurons in distinct temporal phases

1994 • 66 citations

Molecular analysis of the Drosophila EGF receptor homolog reveals that several genetically defined classes of alleles cluster in subdomains of the receptor protein.

1994 • 63 citations

Comparison of the Signaling Abilities of the Drosophila and Human Insulin Receptors in Mammalian Cells

1995 • 50 citations

A role for Raf-1 in the divergent signaling pathways mediating insulin-stimulated glucose transport

1994 • 48 citations

Interallelic complementation among DER/flb alleles: implications for the mechanism of signal transduction by receptor-tyrosine kinases.

1991 • 40 citations

Genetic and phenotypic analysis of thirteen essential genes in cytological interval 22F1-2; 23B1-2 reveals novel genes required for neural development in Drosophila.

1994 • 31 citations

Characterization of an Interaction between Insulin Receptor Substrate 1 and the Insulin Receptor by Using the Two-Hybrid System

1994 • 29 citations

Tissue Localization of Drosophila melanogaster Insulin Receptor Transcripts During Development

1988 • 17 citations