Shear Stress Stimulation of p130 Tyrosine Phosphorylation Requires Calcium-dependent c-Src Activation

Basic Methods in Molecular Biology

1986 • 3,284 citations

Flow-mediated endothelial mechanotransduction

1995 • 2,728 citations

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

1994 • 1,426 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

CAS/Crk Coupling Serves as a “Molecular Switch” for Induction of Cell Migration

1998 • 668 citations

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

1994 • 653 citations

A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5

1988 • 606 citations

Widespread long-term gene transfer to mouse skeletal muscles and heart.

1992 • 586 citations

BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

1997 • 580 citations

Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell Migration

1998 • 501 citations

Fibronectin-Stimulated Signaling from a Focal Adhesion Kinase–c-Src Complex: Involvement of the Grb2, p130^cas, and Nck Adaptor Proteins

1997 • 432 citations

Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas.

1995 • 423 citations

Induction of p130^cas Signaling Complex Formation upon Integrin-Mediated Cell Adhesion: a Role for Src Family Kinases

1996 • 422 citations

Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium.

1994 • 389 citations

p130Cas, a Substrate Associated with v-Src and v-Crk, Localizes to Focal Adhesions and Binds to Focal Adhesion Kinase

1996 • 364 citations

Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas

1998 • 363 citations

Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells

1992 • 355 citations

The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells.

1993 • 338 citations

Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium

1997 • 325 citations

Physiological fluid shear stress causes downregulation of endothelin-1 mRNA in bovine aortic endothelium

1992 • 305 citations

Fluid Shear Stress Stimulates Mitogen-Activated Protein Kinase in Endothelial Cells

1995 • 287 citations

Direct Binding of the Proline-rich Region of Protein Tyrosine Phosphatase 1B to the Src Homology 3 Domain of p130Cas

1996 • 272 citations

The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression.

1995 • 267 citations

Cytoplasmic calcium response to fluid shear stress in cultured vascular endothelial cells

1988 • 248 citations

Shear Stress Activates p60src-Ras-MAPK Signaling Pathways in Vascular Endothelial Cells

1998 • 239 citations

The Ras-JNK Pathway Is Involved in Shear-Induced Gene Expression

1996 • 234 citations

Fluid Shear Stress Transcriptionally Induces Lectin-like Oxidized LDL Receptor-1 in Vascular Endothelial Cells

1998 • 219 citations

Mitogen-activated protein kinase (ERK1/2) activation by shear stress and adhesion in endothelial cells. Essential role for a herbimycin-sensitive kinase.

1996 • 217 citations

Reactive Oxygen Species Are Involved in Shear Stress-Induced Intercellular Adhesion Molecule-1 Expression in Endothelial Cells

1997 • 197 citations

Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway.

1998 • 196 citations

Flow-induced calcium transients in single endothelial cells: spatial and temporal analysis

1992 • 184 citations

Activation of P2Y2 Receptors by UTP and ATP Stimulates Mitogen-activated Kinase Activity through a Pathway That Involves Related Adhesion Focal Tyrosine Kinase and Protein Kinase C

1998 • 179 citations

Fluid Shear Stress Stimulates Big Mitogen-activated Protein Kinase 1 (BMK1) Activity in Endothelial Cells

1999 • 179 citations

Suppression of Angiotensin-Converting Enzyme Expression and Activity by Shear Stress

1997 • 145 citations

Contractile activity-induced adaptations in the mitochondrial protein import system

1998 • 145 citations

Calcium responses of endothelial cell monolayers subjected to pulsatile and steady laminar flow differ

1995 • 139 citations

Shear‐induced platelet‐derived growth factor gene expression in human endothelial cells is mediated by protein kinase C

1992 • 134 citations

The Related Adhesion Focal Tyrosine Kinase Differentially Phosphorylates p130Cas and the Cas-like Protein, p105HEF1

1997 • 128 citations

Tyrosine Phosphorylation of p130Cas Is Involved in Actin Organization in Osteoclasts

1998 • 120 citations

p130CAS Forms a Signaling Complex with the Adapter Protein CRKL in Hematopoietic Cells Transformed by the BCR/ABL Oncogene

1996 • 114 citations

Differential Signaling by the Focal Adhesion Kinase and Cell Adhesion Kinase β

1997 • 113 citations

Negative transcriptional regulation of the VCAM-1 gene by fluid shear stress in murine endothelial cells

1997 • 110 citations

Epidermal Growth Factor Modulates Tyrosine Phosphorylation of p130Cas

1997 • 104 citations

The identification of p130cas-binding proteins and their role in cellular transformation.

1996 • 98 citations

Tyrosine Phosphorylation of p130 by Bombesin, Lysophosphatidic Acid, Phorbol Esters, and Platelet-derived Growth Factor

1997 • 95 citations

A New Monoclonal Antibody Which Selectively Recognizes the Active Form of Src Tyrosine Kinase

1996 • 87 citations

Endothelial cell adhesion in real time. Measurements in vitro by tandem scanning confocal image analysis.

1993 • 78 citations

Activation of Rho-Dependent Cell Spreading and Focal Adhesion Biogenesis by the v-Crk Adaptor Protein

1998 • 73 citations

Mechanical Forces and the Endothelium

1999 • 66 citations

Phosphorylation of p130 ^Cas by Angiotensin II Is Dependent on c-Src, Intracellular Ca ²⁺ , and Protein Kinase C

1998 • 59 citations

Emerging components of the Crk oncogene product: The first identified adaptor protein

1996 • 49 citations

Efficient Transfection of Primary Cells in a Canine Hemophilia B Model Using Adenovirus–Polylysine–DNA Complexes

1994 • 46 citations