Rapid CD4+ T-cell turnover in HIV-1 infection: A paradigm revisited

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Identification of a major co-receptor for primary isolates of HIV-1

1996 • 3,649 citations

Structure and function of telomeres

1991 • 3,524 citations

HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time

1996 • 3,496 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1996 • 3,189 citations

CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1

1996 • 2,735 citations

Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

1997 • 2,011 citations

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

1989 • 1,509 citations

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

1993 • 1,450 citations

High Levels of HIV-1 in Plasma During All Stages of Infection Determined By Competitive PCR

1993 • 1,263 citations

The telomere terminal transferase of tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity

1987 • 1,127 citations

Quantitation of Human Immunodeficiency Virus Type 1 in the Blood of Infected Persons

1989 • 1,090 citations

Age, Thymopoiesis, and CD4+ T-Lymphocyte Regeneration after Intensive Chemotherapy

1995 • 1,066 citations

Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population

1992 • 1,059 citations

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

1995 • 951 citations

Activation of telomerase in human lymphocytes and hematopoietic progenitor cells.

1995 • 871 citations

Prognostic Value of HIV-1 Syncytium-Inducing Phenotype for Rate of CD4+ Cell Depletion and Progression to AIDS

1993 • 780 citations

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.

1993 • 743 citations

Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates

1989 • 662 citations

Telomerase activity in normal leukocytes and in hematologic malignancies

1995 • 619 citations

Quantitative Image Analysis of HIV-1 Infection in Lymphoid Tissue

1996 • 604 citations

Plasma Viremia in Human Immunodeficiency Virus Infection

1989 • 575 citations

Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis

1996 • 452 citations

Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry

1996 • 365 citations

Lymphocyte depletion during treatment with intensive chemotherapy for cancer

1994 • 356 citations

Alterations in the Immune Response of Human Immunodeficiency Virus (HIV)-Infected Subjects Treated with an HIV-Specific Protease Inhibitor, Ritonavir

1996 • 338 citations

Lymphocyte depletion during treatment with intensive chemotherapy for cancer

1994 • 314 citations

T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny

1993 • 293 citations

T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4 ⁺ T Cell Turnover

1996 • 288 citations

T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny

1993 • 250 citations

The peripheral T cell repertoire: independent homeostatic regulation of virgin and activated CD8⁺ T cell pools

1995 • 174 citations

CD34+ bone marrow cells are infected with HIV in a subset of seropositive individuals.

1992 • 173 citations

Changing Virus‐Host Interactions in the Course of HIV‐1 Infection

1994 • 157 citations

Relation between Changes in Cellular Load, Evolution of Viral Phenotype, and the Clonal Composition of Virus Populations in the Course of Human Immunodeficiency Virus Type 1 Infection

1996 • 145 citations

In vitro suppression of normal human bone marrow progenitor cells by human immunodeficiency virus

1991 • 133 citations

Telomere Length, Telomerase Activity, and Replicative Potential in HIV Infection: Analysis of CD4+ and CD8+T Cells from HIV-discordant Monozygotic Twins

1997 • 131 citations

Rapid-high, syncytium-inducing isolates of human immunodeficiency virus type 1 induce cytopathicity in the human thymus of the SCID-hu mouse

1994 • 104 citations

Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN-gamma secreting TH1 cells in humans.

1997 • 92 citations

Telomeres and Telomerase: A Simple Picture Becomes Complex

1996 • 78 citations

Inhibition of purified CD34+ hematopoietic progenitor cells by human immunodeficiency virus 1 or gp120 mediated by endogenous transforming growth factor beta 1.

1996 • 75 citations

Immunosenescence in HIV Pathogenesis

1997 • 73 citations

Evidence for a Human Immunodeficiency Virus Type 1-Mediated Suppression ofUninfected Hematopoietic (CD34+) Cells in AIDS Patients

1992 • 66 citations

Differential tropism of HIV-1 isolates for distinct thymocyte subsets in vitro

1996 • 61 citations

Productive and Persistent Infection of Human Thymic Epithelial Cellsin Vitrowith HIV-1

1996 • 36 citations

Peripheral Blood from Human Immunodeficiency Virus Type 1‐Infected Patients Displays Diminished T Cell Generation Capacity

1997 • 27 citations

Frequency and cytokine profile of HPRT mutant T cells in HIV-infected and healthy donors: implications for T cell proliferation in HIV disease.

1997 • 17 citations