Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN-gamma secreting TH1 cells in humans.

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

Age, Thymopoiesis, and CD4+ T-Lymphocyte Regeneration after Intensive Chemotherapy

1995 • 1,066 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Detection of intracellular cytokines by flow cytometry

1993 • 992 citations

Human naive and memory T cells

1988 • 793 citations

Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry

1995 • 561 citations

Th1 And Th2 Cells: Different Patterns Of Lymphokine Secretion Lead To Different Functional Properties

1989 • 460 citations

Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4.

1985 • 372 citations

Reversal of Experimental Allergic Encephalomyelitis with Monoclonal Antibody to a T-Cell Subset Marker

1985 • 328 citations

Regulation of apoptosis in the immune system

1994 • 321 citations

Treatment of multiple sclerosis with the monoclonal anti-CD4 antibody cM-T412: Results of a randomized, double-blind, placebo-controlled MR-monitored phase II trial

1997 • 261 citations

Regulation of CD27 expression on subsets of mature T-lymphocytes.

1993 • 247 citations

Experimental allergic encephalomyelitis: successful treatment in vivo with a monoclonal antibody that recognizes T helper cells.

1984 • 222 citations

The Th1/Th2 balance in autoimmunity

1995 • 198 citations

A randomized, double‐blind, placebo‐controlled study of cd4 monoclonal antibody therapy in early rheumatoid arthritis

1995 • 194 citations

T Cell Receptors in Murine Autoimmune Diseases

1989 • 137 citations

Use of a chimeric monoclonal anti‐CD4 antibody in patients with refractory rheumatoid arthritis

1993 • 120 citations

CD4 antibody treatment in patients with active Crohn's disease: a phase 1 dose finding study.

1997 • 107 citations

Double‐blind, placebo‐controlled multicenter trial using chimeric monoclonal anti‐cd4 antibody, cm‐t412, in rheumatoid arthritis patients receiving concomitant methotrexate

1995 • 107 citations

Low T-cell responsiveness to activation via CD3/TCR is a prognostic marker for acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus-1 (HIV-1)-infected men

1990 • 104 citations

Heterogeneity of the human CD4+ T-cell population: two distinct CD4+ T- cell subsets characterized by coexpression of CD45RA and CD45RO isoforms

1996 • 101 citations

CD4 engagement induces Fas antigen‐dependent apoptosis of T cells in vivo

1994 • 98 citations

Multiple discrete encephalitogenic epitopes of the autoantigen myelin basic protein include a determinant for I-E class II-restricted T cells.

1988 • 92 citations

Immunological and virological markers in individuals progressing from seroconversion to AIDS

1991 • 86 citations

The CD40 Antigen and Its Ligand

1994 • 82 citations

Repeated treatment with chimeric anti‐CD4 antibody in multiple sclerosis

1994 • 82 citations

Changes in T and non-T lymphocyte subsets following seroconversion to HIV-1: stable CD3+ and declining CD3- populations suggest regulatory responses linked to loss of CD4 lymphocytes. The Multicenter AIDS Cohort Study.

1993 • 79 citations

T-cell homeostasis: implications in HIV infection .

1993 • 76 citations

Chimeric cd4 monoclonal antibody cm‐t412 as a therapeutic approach to rheumatoid arthritis

1993 • 76 citations

Treatment of Rheumatoid Arthritis with Single Dose or Weekly Pulses of Chimaeric Anti‐CD4 Monoclonal Antibody

1992 • 73 citations

Effect of anti-CD4 on CD4 subsets. I. Anti-CD4 preferentially deletes resting, naive CD4 cells and spares activated CD4 cells.

1994 • 70 citations

The progression of the inflammation in established collagen‐induced arthritis can be altered by treatments with immunological or pharmacological agents which inhibit T cell activities

1988 • 68 citations

Peripheral T lymphocyte depletion by apoptosis after CD4 ligationin vivo: selective loss of CD44− and ‘activating’ memory T cells

1994 • 58 citations

Fas (CD95) expression and death-mediating function are induced by CD4 cross-linking on CD4+ T cells.

1996 • 56 citations

Control of immune-mediated disease of the central nervous system with monoclonal (CD4-specific) antibodies

1993 • 55 citations

Th1 and Th2 cells in autoimmunity

1995 • 52 citations

Phase 1 clinical trial of chimeric monoclonal anti‐CD4 antibody in multiple sclerosis

1994 • 52 citations

Differences in the degree of depletion, rate of recovery, and the preferential elimination of naive CD4+ T cells by anti-CD4 monoclonal antibody (GK1.5) in young and aged mice.

1995 • 48 citations

Treatment of Multiple Sclerosis with Anti-CD4 Monoclonal Antibody

1993 • 41 citations

The T Lymphocyte In Experimental Allergic Encephalomyelitis

1990 • 41 citations

Suppression of experimental antiphospholipid syndrome and systemic lupus erythematosus in mice by anti‐CD4 monoclonal antibodies

1994 • 35 citations

In vivotreatment with a monoclonal antibody to T helper cells in experimental autoimmune glomerulonephritis in the BN rat

1994 • 34 citations

A phase II trial of anti-CD4 antibodies in the treatment of multiple sclerosis

1996 • 31 citations

Experimental allergic encephalomyelitis in rhesus monkeys: II. Treatment of EAE with anti-T lymphocyte subset monoclonal antibodies.

1987 • 31 citations

Kinetics of anti-CD4-induced T helper cell depletion and inhibition of function. Activation of T cells by the CD3 pathway inhibits anti-CD4-mediated T cell elimination and down-regulation of cell surface CD4.

1992 • 28 citations

Experimental allergic encephalomyelitis in rhesus monkeys: I. Immunological parameters in EAE resistant and susceptible rhesus monkeys.

1987 • 26 citations

Treatment with an anti-CD4 monoclonal antibody strongly ameliorates established rat adjuvant arthritis

1996 • 26 citations

Simultaneous regulation of CD2 adhesion and signaling functions by a novel CD2 monoclonal antibody.

1994 • 21 citations

Anti-CD4 Monoclonal Antibodies Suppress Murine Collagen-Induced Arthritis Only at the Time of Primary Immunisation

1996 • 17 citations

Immunological follow-up of 17 patients with rheumatoid arthritis treated in vivo with an anti-T CD4+ monoclonal antibody (B-F5)

1992 • 15 citations

The Regulation of Autoimmunity Through CD4+ T Cells

1993 • 14 citations

Th1 and Th2 Cells in Autoimmunity

1996 • 12 citations

Functional defects in peripheral blood T cells of multiple sclerosis patients

1994 • 11 citations

Regulation of autoimmunity

1991 • 9 citations

T Cell Receptors In Murine Autoimmune Diseases

1989 • 8 citations

T cell antigen receptor engagement abrogates CD4-mediated T cell deletion in vivo

1995 • 8 citations