Telomeres and Telomerase: A Simple Picture Becomes Complex

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

1985 • 3,331 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

Telomere elongation in immortal human cells without detectable telomerase activity.

1995 • 1,249 citations

The telomere terminal transferase of tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity

1987 • 1,127 citations

TELOMERE LENGTH REGULATION

1996 • 1,010 citations

A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena

1978 • 1,003 citations

An alternative pathway for yeast telomere maintenance rescues est1− senescence

1993 • 916 citations

A Human Telomeric Protein

1995 • 689 citations

Developmental and tissue-specific regulation of mouse telomerase and telomere length.

1995 • 686 citations

Single-Stranded DNA Arising at Telomeres in cdc13 Mutants May Constitute a Specific Signal for the RAD9 Checkpoint

1995 • 632 citations

Hypervariable ultra-long telomeres in mice

1990 • 612 citations

Telomere-Led Premeiotic Chromosome Movement in Fission Yeast

1994 • 473 citations

Telomerase, Cell Immortality, and Cancer

1994 • 405 citations

Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues.

1996 • 403 citations

Telomerase and DNA End Replication: No Longer a Lagging Strand Problem?

1995 • 385 citations

Telomere dynamics in an immortal human cell line.

1994 • 380 citations

Functional Characterization and Developmental Regulation of Mouse Telomerase RNA

1995 • 366 citations

Runaway telomere elongation caused by telomerase RNA gene mutations

1995 • 338 citations

The Crystal Structure of the DNA-Binding Domain of Yeast RAP1 in Complex with Telomeric DNA

1996 • 306 citations

Evidence for a New Step in Telomere Maintenance

1996 • 304 citations

Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis

1996 • 291 citations

Activation of telomerase in a human tumor.

1994 • 289 citations

Purification of tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme

1995 • 252 citations

Variability at the Telomeres of the Human X/Y Pseudoautosomal Region

1986 • 229 citations

Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase.

1996 • 226 citations

Extensive telomere repeat arrays in mouse are hypervariable

1990 • 177 citations

Generation of telomere-length heterogeneity in Saccharomyces cerevisiae.

1988 • 170 citations

Telomerase Activation in Mouse Mammary Tumors: Lack of Detectable Telomere Shortening and Evidence for Regulation of Telomerase RNA with Cell Proliferation

1996 • 157 citations

Evidence for clonal attenuation of growth potential in hela cells

1978 • 40 citations