Selective Accumulation of Related CD4+ T Cell Clones in the Synovial Fluid of Patients with Rheumatoid Arthritis

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

1987 • 2,539 citations

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

1997 • 1,651 citations

Rheumatoid Arthritis

1990 • 1,565 citations

Release of Infectious Epstein-Barr Virus by Transformed Marmoset Leukocytes

1973 • 960 citations

Vβ-Specific Stimulation of Human T Cells by Staphylococcal Toxins

1989 • 711 citations

A Molecular Basis for MHC Class II—Associated Autoimmunity

1988 • 707 citations

RHEUMATOID ARTHRITIS: A DISEASE OF T-LYMPHOCYTE/MACROPHAGE IMMUNOREGULATION

1981 • 670 citations

Human T-cell receptor variable gene segment families

1995 • 663 citations

Evidence for the Effects of a Superantigen in Rheumatoid Arthritis

1991 • 632 citations

Repeated therapy with monoclonal antibody to tumour necrosis factor α (cA2) in patients with rheumatoid arthritis

1994 • 632 citations

Superantigens and Their Potential Role in Human Disease

1993 • 620 citations

The T Cell Receptor

1987 • 554 citations

How important are t cells in chronic rheumatoid synovitis?

1990 • 553 citations

The Influence of HLA-DRB1 Genes on Disease Severity in Rheumatoid Arthritis

1992 • 520 citations

CDR3 length in antigen-specific immune receptors.

1994 • 503 citations

T Cells Responsive to Myelin Basic Protein in Patients with Multiple Sclerosis

1990 • 447 citations

Taking mortality in rheumatoid arthritis seriously--predictive markers, socioeconomic status and comorbidity.

1986 • 328 citations

Limited T-cell receptor beta-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis.

1991 • 297 citations

The role of T cells in the immunopathogenesis of rheumatoid arthritis. New perspectives

1997 • 295 citations

An immunohistological analysis of lymphocyte subpopulations and their microenvironment in the synovial membranes of patients with rheumatoid arthritis using monoclonal antibodies.

1982 • 273 citations

Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis.

1995 • 252 citations

Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis.

1992 • 229 citations

A randomized, double‐blind, placebo‐controlled study of cd4 monoclonal antibody therapy in early rheumatoid arthritis

1995 • 194 citations

Could HLA-DRB1 be the protective locus in rheumatoid arthritis?

1995 • 178 citations

T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis.

1996 • 174 citations

The Human T-Cell Receptor TCRAC/TCRDC (Cα/Cdelta;) Region: Organization, Sequence, and Evolution of 97.6 kb of DNA

1994 • 169 citations

Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis.

1994 • 159 citations

Increased Frequency of HLA‐Cw3 and HLA‐Dw4 in Rheumatoid Arthritis

1977 • 149 citations

Biologic agents for treating rheumatoid arthritis. Concepts and progress

1997 • 137 citations

How αβ T-cell receptors ‘see’ peptide/MHC complexes

1993 • 124 citations

Double‐blind, placebo‐controlled multicenter trial using chimeric monoclonal anti‐cd4 antibody, cm‐t412, in rheumatoid arthritis patients receiving concomitant methotrexate

1995 • 107 citations

T cell receptors in rheumatoid arthritis

1995 • 96 citations

Selective and nonselective stages in homing of T lymphocytes to the central nervous system during experimental allergic encephalomyelitis.

1993 • 87 citations

High frequencies of identical T cell clonotypes in synovial tissues of rheumatoid arthritis patients suggest the occurrence of common antigen‐driven immune responses

1996 • 83 citations

Treatment of Rheumatoid Arthritis with Single Dose or Weekly Pulses of Chimaeric Anti‐CD4 Monoclonal Antibody

1992 • 73 citations

Association of the shared epitope with radiological severity of rheumatoid arthritis.

1996 • 70 citations

CDR3 Size Spectratyping and Sequencing of Spectratype-Derived TCR of Spinal Cord T Cells in Autoimmune Encephalomyelitis

1998 • 63 citations

Diverse T cell receptor V beta gene usage in the central nervous system in experimental allergic encephalomyelitis.

1993 • 62 citations

CDR3 sequence motifs shared by oligoclonal rheumatoid arthritis synovial T cells. Evidence for an antigen-driven response.

1994 • 61 citations

Selection of T cells reactive against autologous B lymphoblastoid cells during chronic rheumatoid arthritis.

1996 • 55 citations

Persistence of dominant T cell clones in synovial tissues during rheumatoid arthritis.

1996 • 54 citations

Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis

1994 • 50 citations

Expectation bias in rheumatoid arthritis clinical trials. The anti‐CD4 monoclonal antibody experience

1996 • 49 citations

A possible role of two hydrophobic amino acids in antigen recognition by synovial T cells in rheumatoid arthritis

1993 • 41 citations

Evidence for selective in vivo expansion of synovial tissue-infiltrating CD4⁺ CD45RO⁺ T lymphocytes on the basis of CDR3 diversity

1994 • 39 citations

A versatile method to produce antibodies to human T cell receptor V_β segments: frequency determination of human V_β2⁺ T cells that react with toxic‐shock syndrome toxin‐1

1992 • 32 citations

Increased usage of v_β2 and v_β6 in rheumatoid synovial fluid t cells

1994 • 31 citations

The genotypic distribution of shared‐epitope DRB1 alleles suggests a recessive mode of inheritance of the rheumatoid arthritis disease‐susceptibility gene

1995 • 30 citations

T-cell receptor variable region of the β-chain gene use in peripheral blood and multiple synovial membranes during rheumatoid arthritis

1995 • 27 citations

Genetic analysis of low V beta 3 expression in humans.

1994 • 25 citations

Characterization of monoclonal antibodies specific for the Vβ3 family of the human T cell receptor generated using soluble TCR β-chain

1993 • 13 citations

Characterization of Oligoclonal Synovial T‐Cells in Rheumatoid Arthritis

1995 • 4 citations

Unstimulated Rheumatoid Synovial T‐Cells Have a Consistent Vβ Gene Bias when Compared to Peripheral Blood T‐Cells

1995 • 3 citations