p38 Mitogen-Activated Protein Kinase Mediates Cell Death and p21-Activated Kinase Mediates Cell Survival during Chemotherapeutic Drug-induced Mitotic Arrest

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

2001 • 3,295 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

1997 • 1,805 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

1999 • 1,255 citations

Cytosol-to-membrane redistribution of Bax and Bcl-X_Lduring apoptosis

1997 • 1,117 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

2000 • 778 citations

Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.

1996 • 777 citations

Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2

1997 • 742 citations

Conformation of the Bax C-terminus regulates subcellular location and cell death

1999 • 723 citations

Bax-induced Caspase Activation and Apoptosis via Cytochromec Release from Mitochondria Is Inhibitable by Bcl-xL

1999 • 717 citations

Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

1998 • 645 citations

Immunocytochemical detection and mapping of a cytokeratin 18 neo-epitope exposed during early apoptosis

1999 • 639 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Paclitaxel-induced cell death

2000 • 618 citations

Identification of a Human Mitotic Checkpoint Gene: hsMAD2

1996 • 609 citations

Characterization of the Structure and Function of the Fourth Member of p38 Group Mitogen-activated Protein Kinases, p38δ

1997 • 482 citations

Apoptosis Induced by Withdrawal of Trophic Factors Is Mediated by p38 Mitogen-activated Protein Kinase

1997 • 471 citations

Anaphase-Promoting Complex/Cyclosome–Dependent Proteolysis of Human Cyclin a Starts at the Beginning of Mitosis and Is Not Subject to the Spindle Assembly Checkpoint

2001 • 413 citations

p38 Map Kinase Mediates Bax Translocation in Nitric Oxide–Induced Apoptosis in Neurons

2000 • 391 citations

PAK to the future

1999 • 391 citations

Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells.

2000 • 359 citations

p21-Activated Kinase 1 Phosphorylates the Death Agonist Bad and Protects Cells from Apoptosis

2000 • 356 citations

Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

1998 • 353 citations

The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics

1991 • 313 citations

BAD Ser-155 Phosphorylation Regulates BAD/Bcl-XL Interaction and Cell Survival

2000 • 304 citations

Microtubule-interfering Agents Stimulate the Transcription of Cyclooxygenase-2

2000 • 301 citations

Taxol-Induced Mitotic Block Triggers Rapid Onset of a p53-Independent Apoptotic Pathway

1995 • 281 citations

Waiting for Anaphase

2000 • 279 citations

The ups and downs of MEK kinase interactions

2001 • 277 citations

How BAD phosphorylation is good for survival

1999 • 242 citations

The Akt Proto-oncogene Links Ras to Pak and Cell Survival Signals

2000 • 235 citations

The Jun Kinase/Stress-activated Protein Kinase Pathway Functions to Regulate DNA Repair and Inhibition of the Pathway Sensitizes Tumor Cells to Cisplatin

1997 • 230 citations

Coupling cell division and cell death to microtubule dynamics

1997 • 228 citations

Microtubule dynamics: taking aim at a moving target

1995 • 217 citations

The Serine/Threonine Kinase PAK4 Prevents Caspase Activation and Protects Cells from Apoptosis

2001 • 200 citations

p38 Mitogen-activated Protein Kinase Pathway Protects Adult Rat Ventricular Myocytes against β-Adrenergic Receptor-stimulated Apoptosis

2000 • 161 citations

Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells

1999 • 150 citations

Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways.

2000 • 139 citations

Calcium/Calmodulin-dependent Phosphorylation and Activation of Human Cdc25-C at the G2/M Phase Transition in HeLa Cells

1999 • 137 citations

Role of p38-Mitogen-Activated Protein Kinase in Spontaneous Apoptosis of Human Neutrophils

1999 • 132 citations

MEK Kinase 1 (MEKK1) Transduces c-Jun NH2-terminal Kinase Activation in Response to Changes in the Microtubule Cytoskeleton

1999 • 125 citations

Involvement of p38 in Apoptosis-associated Membrane Blebbing and Nuclear Condensation

2001 • 121 citations

Paclitaxel Induces Prolonged Activation of the Ras/MEK/ERK Pathway Independently of Activating the Programmed Cell Death Machinery

2001 • 117 citations

p21-activated Protein Kinase γ-PAK Suppresses Programmed Cell Death of BALB3T3 Fibroblasts

2001 • 111 citations

Selective Potentiation of Paclitaxel (Taxol)-Induced Cell Death by Mitogen-Activated Protein Kinase Kinase Inhibition in Human Cancer Cell Lines

2001 • 110 citations

The Role of ERK 1/2 and p38 MAP-Kinase Pathways in Taxol-Induced Apoptosis in Human Ovarian Carcinoma Cells

2001 • 103 citations

Complexity in the spindle checkpoint

2000 • 90 citations

MEK Kinase 3 Directly Activates MKK6 and MKK7, Specific Activators of the p38 and c-Jun NH2-terminal Kinases

1999 • 90 citations

Control of mitotic transitions by the anaphase–promoting complex

1999 • 85 citations

A member of the Ste20/PAK family of protein kinases is involved in both arrest of Xenopus oocytes at G2/prophase of the first meiotic cell cycle and in prevention of apoptosis

1997 • 84 citations

Inhibition of extracellular signal-regulated kinase (ERK) mediates cell cycle phase independent apoptosis in vinblastine-treated ML-1 cells.

2001 • 64 citations

p21WAF1 is dynamically associated with JNK in human T-lymphocytes during cell cycle progression

1998 • 50 citations