Microtubule dynamics: taking aim at a moving target

Dynamic instability of microtubule growth

1984 • 3,187 citations

Feedback control of mitosis in budding yeast

1991 • 1,167 citations

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

1991 • 1,125 citations

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations.

1993 • 1,086 citations

Taxol binds to polymerized tubulin in vitro

1981 • 618 citations

Opposite end assembly and disassembly of microtubules at steady state in vitro

1978 • 567 citations

Mechanism of inhibition of cell proliferation by Vinca alkaloids.

1991 • 534 citations

Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles : Implications for the role of microtubule dynamics in mitosis

1992 • 521 citations

Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau

1994 • 391 citations

Structure of Curacin A, a Novel Antimitotic, Antiproliferative and Brine Shrimp Toxic Natural Product from the Marine Cyanobacterium Lyngbya majuscula

1994 • 347 citations

Substoichiometric Binding of Taxol Suppresses Microtubule Dynamics

1995 • 331 citations

3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin.

1994 • 244 citations

Kinetic stabilization of microtubule dynamic instability in vitro by vinblastine

1993 • 240 citations

Cryptophycin: a new antimicrotubule agent active against drug-resistant cells.

1994 • 217 citations

Taxane Anticancer Agents

1994 • 189 citations

Natural products which interact with tubulin in the vinca domain: Maytansine, rhizoxin, phomopsin a, dolastatins 10 and 15 and halichondrin B

1992 • 186 citations

Kinetic Stabilization of Microtubule Dynamics at Steady State by Tau and Microtubule-Binding Domains of Tau

1995 • 174 citations

Molecular Structure and Function of Microtubule-Associated Proteins

1991 • 166 citations

Vinblastine suppresses dynamics of individual microtubules in living interphase cells.

1995 • 161 citations

Kinetic Stabilization of Microtubule Dynamics at Steady State in Vitro by Substoichiometric Concentrations of Tubulin-Colchicine Complex

1995 • 88 citations

LU103793 (NSC D-669356): a synthetic peptide that interacts with microtubules and inhibits mitosis.

1995 • 61 citations

Microtubule Polymerization Dynamics, Mitotic Block, and Cell Death by Paclitaxel at Low Concentrations

1994 • 22 citations

Deleted Work

1955 • 0 citations