Role of p38-Mitogen-Activated Protein Kinase in Spontaneous Apoptosis of Human Neutrophils

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

1989 • 1,540 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products

1992 • 1,103 citations

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

1996 • 1,099 citations

Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide.

1985 • 796 citations

Single-step separation of red blood cells, granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque

1974 • 735 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators

1993 • 726 citations

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.

1996 • 650 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils.

1996 • 574 citations

Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony-stimulating factor is caused by inhibition of programmed cell death

1992 • 367 citations

Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase

1996 • 346 citations

Involvement of Reactive Oxygen Intermediates in Spontaneous and CD95(Fas/APO-1)–Mediated Apoptosis of Neutrophils

1997 • 334 citations

Differential expression of bcl-2 and susceptibility to anti-Fas- mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils

1994 • 320 citations

Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases

1997 • 314 citations

Fas Activation of the p38 Mitogen-Activated Protein Kinase Signalling Pathway Requires ICE/CED-3 Family Proteases

1997 • 285 citations

p38 Mitogen-activated Protein Kinase-dependent and -independent Intracellular Signal Transduction Pathways Leading to Apoptosis in Human Neutrophils

1998 • 282 citations

Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide.

1996 • 240 citations

Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants.

1994 • 212 citations

Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils.

1994 • 205 citations

Hypoxia prolongs neutrophil survival in vitro

1995 • 203 citations

Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.

1995 • 187 citations

Chemotactic Peptide N-formyl-Met-Leu-Phe Activation of p38 Mitogen-activated Protein Kinase (MAPK) and MAPK-activated Protein Kinase-2 in Human Neutrophils

1997 • 184 citations

Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes

1996 • 166 citations

Fas Induces Cytoplasmic Apoptotic Responses and Activation of the MKK7-JNK/SAPK and MKK6-p38 Pathways Independent of CPP32-like Proteases

1997 • 154 citations

Transient elevations of cytosolic free calcium retard subsequent apoptosis in neutrophils in vitro.

1993 • 141 citations

A comparison of the substrate specificity of MAPKAP kinase‐2 and MAPKAP kinase‐3 and their activation by cytokines and cellular stress

1996 • 137 citations

Agents That Elevate cAMP Inhibit Human Neutrophil Apoptosis

1995 • 137 citations

Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophils stimulated with various agonists

1996 • 131 citations

Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor.

1996 • 127 citations

Tumour necrosis factor-α-induced phosphorylation and activation of cytosolic phospholipase A2 are abrogated by an inhibitor of the p38 mitogen-activated protein kinase cascade in human neutrophils

1996 • 126 citations

Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products

1992 • 108 citations

The Critical Role of p38 MAP Kinase in T Cell HIV-1 Replication

1997 • 107 citations

Augmented Intracellular Glutathione Inhibits Fas-Triggered Apoptosis of Activated Human Neutrophils

1997 • 97 citations

The activation of distinct mitogen-activated protein kinase cascades is required for the stimulation of 2-deoxyglucose uptake by interleukin-1 and insulin-like growth factor-1 in KB cells

1995 • 91 citations

Differential Effects of a Mitogen-Activated Protein Kinase Kinase Inhibitor on Human Neutrophil Responses to Chemotactic Factors

1997 • 72 citations

Neutrophil superoxide release is required for spontaneous and FMLP-mediated but not for TNF alpha-mediated apoptosis.

1997 • 69 citations

The Expression of Genes Modulating Programmed Cell Death in Normal Human Polymorphonuclear Neutrophils

1997 • 61 citations

Characterization of two different forms of mitogen-activated protein kinase kinase induced in polymorphonuclear leukocytes following stimulation by N-formylmethionyl-leucyl-phenylalanine or granulocyte-macrophage colony-stimulating factor

1994 • 54 citations

Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony-stimulating factor is caused by inhibition of programmed cell death

1992 • 43 citations