Pharmacology of penile erection.

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

A review of central 5-HT receptors and their function

1999 • 3,121 citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

1990 • 2,996 citations

Prostanoid Receptors: Structures, Properties, and Functions

1999 • 2,395 citations

Distribution of serotonin-immunoreactivity in the central nervous system of the rat—Cell bodies and terminals

1981 • 2,392 citations

Adrenomedullin: A Novel Hypotensive Peptide Isolated from Human Pheochromocytoma

1993 • 2,176 citations

Signal transduction and regulation in smooth muscle

1994 • 1,915 citations

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

1995 • 1,780 citations

International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.

1994 • 1,729 citations

The paraventricular nucleus of the hypothalamus: Cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double‐labeling methods

1980 • 1,391 citations

Targeted disruption of the neuronal nitric oxide synthase gene

1993 • 1,300 citations

Signal transduction by G‐proteins, Rho‐kinase and protein phosphatase to smooth muscle and non‐muscle myosin II

2000 • 1,219 citations

Guanylyl cyclases and signaling by cyclic GMP.

2000 • 1,192 citations

Nitric Oxide: A Physiologic Mediator of Penile Erection

1992 • 1,187 citations

Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat

1982 • 1,149 citations

INCIDENCE OF ERECTILE DYSFUNCTION IN MEN 40 TO 69 YEARS OLD: LONGITUDINAL RESULTS FROM THE MASSACHUSETTS MALE AGING STUDY

2000 • 1,135 citations

Physiology of penile erection

1995 • 1,113 citations

Common precursor to corticotropins and endorphins

1977 • 1,106 citations

Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction.

1996 • 1,070 citations

Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat

1978 • 1,022 citations

Impaired Neurogenic and Endothelium-Mediated Relaxation of Penile Smooth Muscle from Diabetic Men with Impotence

1989 • 960 citations

GABAA and GABAB receptor site distribution in the rat central nervous system

1987 • 865 citations

Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat

1978 • 824 citations

Calcium movements, distribution, and functions in smooth muscle.

1997 • 750 citations

Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

2000 • 739 citations

International Union of Pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide.

1998 • 722 citations

International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update.

1995 • 694 citations

Pharmacology of lower urinary tract smooth muscles and penile erectile tissues.

1993 • 694 citations

EFFECTS OF SILDENAFIL ON THE RELAXATION OF HUMAN CORPUS CAVERNOSUM TISSUE IN VITRO AND ON THE ACTIVITIES OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ISOZYMES

1998 • 595 citations

Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.

1993 • 588 citations

Treatment of Men with Erectile Dysfunction with Transurethral Alprostadil

1997 • 566 citations

Sildenafil, a novel effective oral therapy for male erectile dysfunction

1996 • 566 citations

Plasma Oxytocin Increases in the Human Sexual Response*

1987 • 546 citations

Defective smooth muscle regulation in cGMP kinase I-deficient mice

1998 • 510 citations

Pharmacology of cotransmission in the autonomic nervous system: integrative aspects on amines, neuropeptides, adenosine triphosphate, amino acids and nitric oxide.

1996 • 490 citations

Efficacy and Safety of Intracavernosal Alprostadil in Men with Erectile Dysfunction

1996 • 484 citations

Endocrine Consequences of Long-Term Intrathecal Administration of Opioids

2000 • 455 citations

Yohimbine: a pharmacological probe for study of the alpha 2-adrenoreceptor.

1983 • 435 citations

Pharmacological analysis of male rat sexual behavior

1987 • 427 citations

Pharmacology of nociceptin and its receptor: a novel therapeutic target

2000 • 426 citations

Oxytocin and sexual behavior

1992 • 417 citations

Topographic principles in the spinal projections of serotonergic and non-serotonergic brainstem neurons in the rat

1985 • 411 citations

Vesicular acetylcholine transporter (VAChT) protein: A novel and unique marker for cholinergic neurons in the central and peripheral nervous systems

1997 • 409 citations

Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase

1999 • 396 citations

YOHIMBINE FOR ERECTILE DYSFUNCTION: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS

1998 • 383 citations

Auto-Injection of the Corpus Cavernosum with a Vasoactive Drug Combination for Vasculogenic Impotence

1985 • 373 citations

The Endothelial Nitric-oxide Synthase-Caveolin Regulatory Cycle

1998 • 357 citations

Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A

2000 • 354 citations

Nitric Oxide in the Penis: Physiology and Pathology

1997 • 352 citations

Yohimbine induced anxiety and increased noradrenergic function in humans: Effects of diazepam and clonidine

1983 • 350 citations

The orphan opioid receptor and its endogenous ligand — nociceptin/orphanin FQ

1997 • 330 citations

Effects of a new type of 5-HT receptor agonist on male rat sexual behavior

1981 • 327 citations

Trazodone

1994 • 325 citations

NADPH diaphorase in the spinal cord of rats

1992 • 321 citations

New aspects on the melanocortins and their receptors

2000 • 320 citations

The Rationale for Prostaglandin E1 in Erectile Failure: A Survey of Worldwide Experience

1996 • 319 citations

Changes In Oxytocin and Vasopressin Secretion During Sexual Activity in Men

1987 • 318 citations

Overall cardiovascular profile of sildenafil citrate

1999 • 313 citations

Pharmacological subclassification of α₁‐adrenoceptors in vascular smooth muscle

1990 • 308 citations

Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway

2001 • 304 citations

Evidence of an incerto-hypothalamic dopamine neurone system in the rat

1975 • 298 citations

NEURAL CONTROL OF PENILE ERECTION

1995 • 295 citations

Subtype Specific Regulation of Human Vascular α ₁ -Adrenergic Receptors by Vessel Bed and Age

1999 • 291 citations

Neuronal nitric oxide synthase alternatively spliced forms: Prominent functional localizations in the brain

1997 • 279 citations

Nitric oxide synthase immunoreactivity in the rat, mouse, cat and squirrel monkey spinal cord

1993 • 277 citations

Cyclic-3′,5′-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney

1999 • 275 citations

Opioids and sexual behavior

1987 • 271 citations

Gap Junctions in Vascular Tissues

1996 • 270 citations

Anatomical distribution and ultrastructural organization of the gabaergic system in the rat spinal cord. An immunocytochemical study using anti-GABA antibodies

1987 • 268 citations

Serotonergic projections from the ventral medulla to the intermediolateral cell column in the rat

1981 • 259 citations

Origin and termination of the diencephalo-spinal dopamine system in the rat

1982 • 258 citations

Effects of sildenafil, a type‐5 cGMP phosphodiesterase inhibitor, and papaverine on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro

1997 • 257 citations

DOUBLE-BLIND TRIAL OF YOHIMBINE IN TREATMENT OF PSYCHOGENIC IMPOTENCE

1987 • 254 citations

Investigative Urology: PGE sub 1 Suppresses the Induction of Collagen Synthesis by Transforming Growth Factor-beta sub 1 in Human Corpus Cavernosum Smooth Muscle

1995 • 251 citations

Physiological Features of Visceral Smooth Muscle Cells, With Special Reference to Receptors and Ion Channels

1998 • 249 citations

Immunohistochemical Localization of Nitric Oxide Synthase in the Autonomic Innervation of the Human Penis

1993 • 249 citations

Rat spinal cord neurons contain nitric oxide synthase

1994 • 239 citations

Apomorphine-induced penile erection and yawning: site of action in brain

1987 • 236 citations

Fluoxetine-induced sexual dysfunction and an open trial of yohimbine.

1992 • 234 citations

BEHAVIORAL EFFECTS INDUCED BY INTRACISTERNALLY INJECTED ACTH AND MSH*

1963 • 226 citations

Nitric Oxide-Dependent Penile Erection in Mice Lacking Neuronal Nitric Oxide Synthase

1996 • 224 citations

NEW INSIGHTS INTO DOPAMINERGIC RECEPTOR FUNCTION USING ANTISENSE AND GENETICALLY ALTERED ANIMALS

1999 • 220 citations

Effect of YC‐1, an NO‐independent, superoxide‐sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators

1997 • 220 citations

Advanced glycation end products in human penis: elevation in diabetic tissue, site of deposition, and possible effect through inos or enos

1997 • 219 citations

Organization of diencephalic dopamine neurones projecting to the spinal cord in the rat

1985 • 211 citations

Autoradiographic mapping of 5-HT1, 5-HT1A, 5-HT1B and 5-HT2 receptors in the rat spinal cord

1991 • 207 citations

Cyclic Nucleotide Phosphodiesterases and Vascular Smooth Muscle

1996 • 205 citations

Efficacy and safety of sildenafil citrate in the treatment of erectile dysfunction in patients with ischemic heart disease

1999 • 204 citations

Cigarette Smoking: An Independent Risk Factor for Impotence?

1994 • 202 citations

Mechanism of YC-1-Induced Activation of Soluble Guanylyl Cyclase

1998 • 201 citations

Gap junction-mediated intercellular diffusion of Ca2+ in cultured human corporal smooth muscle cells

1992 • 200 citations

Central neural regulation of penile erection

2000 • 200 citations

Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells

1998 • 198 citations

Hypercholesterolemia Impairs Endothelium-Dependent Relaxation of Rabbit Corpus Cavernosum Smooth Muscle

1991 • 197 citations

Immunohistochemical localization of peripheral nitric oxide synthase‐containing nerves using antibodies raised against synthesized C‐ and N‐terminal fragments of a cloned enzyme from rat brain

1993 • 195 citations

Metabolism of prostaglandins A1 and E1 in man.

1975 • 195 citations

Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice

2000 • 194 citations

A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes

1992 • 191 citations

Melanocortin receptors: perspectives for novel drugs

1999 • 190 citations

Autoradiographic localization of 5-hydroxytryptamine1A, 5-hydroxytryptamine1B and 5-hydroxytryptamine1C/2 binding sites in the rat spinal cord

1993 • 185 citations

Reduction of penile nitric oxide synthase in diabetic BB/WORdp (type I) and BBZ/WORdp (type II) rats with erectile dysfunction.

1995 • 182 citations

The effect of androgen on nitric oxide synthase in the male reproductive tract of the rat

1995 • 178 citations

Is Yohimbine Effective in the Treatment of Organic Impotence? Results of a Controlled Trial

1987 • 176 citations

Tissue Angiotensin II as a Modulator of Erectile Function. I. Angiotensin Peptide Content, Secretion and Effects in the Corpus Cavernosum

1997 • 175 citations

Drugs affecting dopamine neurons and yawning behavior

1977 • 175 citations

Recovery of erectile function by the oral administration of apomorphine

1995 • 172 citations

YC-1 Potentiates Nitric Oxide- and Carbon Monoxide-Induced Cyclic GMP Effects in Human Platelets

1998 • 172 citations

Paraventricular nucleus lesion prevents yawning and penile erection induced by apomorphine and oxytocin but not by ACTH in rats

1987 • 171 citations

SYNTHETIC MELANOTROPIC PEPTIDE INITIATES ERECTIONS IN MEN WITH PSYCHOGENIC ERECTILE DYSFUNCTION: DOUBLE-BLIND, PLACEBO CONTROLLED CROSSOVER STUDY

1998 • 170 citations

Functional characteristics of heterologously expressed 5-HT receptors

1997 • 169 citations

THE PENIS AS A VASCULAR ORGAN

1995 • 168 citations

Effect of Yohimbine Hydrochloride on Erectile Impotence: A Double-Blind Study

1989 • 161 citations

Expression of Three Isoforms of cGMP-Binding cGMP-Specific Phosphodiesterase (PDE5) in Human Penile Cavernosum

2000 • 159 citations

Diabetes Mellitus Impairs Neurogenic and Endothelium-Dependent Relaxation of Rabbit Corpus Cavernosum Smooth Muscle

1992 • 159 citations

Pilot experiments on the actions of drugs injected into the human corpus cavernosum penis

1986 • 158 citations

Erectile Dysfunction Due to Atherosclerotic Vascular Disease: The Development of an Animal Model

1992 • 157 citations

Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in α‐adrenoceptor responsiveness with age and disease in isolated tissues

1990 • 155 citations

Effects of 5, 7-dihydroxytryptamine on serotonin1 and serotonin2 receptors throughout the rat central nervous system using quantitative autoradiography

1987 • 155 citations

Nitric oxide and neurons

1992 • 152 citations

Involvement of 5-HT1C-receptors in drug-induced penile erections in rats

1990 • 151 citations

Selective histochemical demonstration of dopamine terminal systems in rat di- and telecephalon: New evidence for dopaminergic innervation of hypothalamic neurosecretory nuclei

1984 • 149 citations

Evidence for the Modulation of Sexual Behavior by α-Adrenoceptors in Male Rats

1985 • 149 citations

Opiate use and sexual function

1980 • 148 citations

SILDENAFIL, A TYPE-5 CGMP PHOSPHODIESTERASE INHIBITOR, SPECIFICALLY AMPLIFIES ENDOGENOUS cGMP-DEPENDENT RELAXATION IN RABBIT CORPUS CAVERNOSUM SMOOTH MUSCLE IN VITRO

1998 • 146 citations

Neuromodulation of penile erection: an overview of the role of neurotransmitters and neuropeptides

1995 • 145 citations

Brain monoaminergic control of male reproductive behavior. II. Dopamine and the post-ejaculatory refractory period

1984 • 143 citations

Transmitter Role of Vasoactive Intestinal Peptide

1993 • 143 citations

Oxytocinergic innervation of autonomic nuclei controlling penile erection in the rat

1999 • 142 citations

Behavioral effects of ACTH and MSH peptides

1981 • 141 citations

Clinical Pharmacology of Potassium Channel Openers

1992 • 139 citations

Androgen and Pituitary Control of Penile Nitric Oxide Synthase and Erectile Function in the Rat1

1996 • 139 citations

Oxytocin-immunoreactive terminals synapse on oxytocin neurones in the supraoptic nucleus

1985 • 139 citations

Spinal and brain circuits to motoneurons of the bulbospongiosus muscle: Retrograde transneuronal tracing with rabies virus

1999 • 137 citations

Effects of morphine, β-endorphin and naloxone on catecholamine levels and sexual behavior in the male rat

1980 • 136 citations

Endothelin: localization, synthesis, activity, and receptor types in human penile corpus cavernosum

1991 • 135 citations

Hemodynamics of Papaverine- and Phentolamine-Induced Penile Erection

1986 • 134 citations

Erectile dysfunction: from biochemical pharmacology to advances in medical therapy

2000 • 132 citations

ACTH- and α-MSH-induced grooming, stretching, yawning and penile erection in male rats: Site of action in the brain and role of melanocortin receptors

2000 • 131 citations

Contextual approaches to the physiology and classification of erectile function, erectile dysfunction, and sexual arousal

2000 • 131 citations

Oxytocin: an extremely potent inducer of penile erection and yawning in male rats

1986 • 131 citations

Neural pathways and central sites involved in penile erection: neuroanatomy and clinical implications

2000 • 129 citations

Nitric oxide mediated erectile activity is a testosterone dependent event: a rat erection model.

1995 • 129 citations

Human recombinant soluble guanylyl cyclase: Expression, purification, and regulation

2000 • 128 citations

Opposite influence of medial preoptic D1 and D2 receptors on genital reflexes: Implications for copulation

1992 • 128 citations

Pathophysiology of Prolonged Penile Erection associated with Trazodone Use

1991 • 123 citations

Assessment of α2 adrenergic autoreceptor function in humans: Effects of oral yohimbine

1982 • 123 citations

5-HT2C receptors mediate penile erections in rats: actions of novel and selective agonists and antagonists

1997 • 122 citations

Effects of lesions in the paraventricular nucleus of the hypothalamus on vasopressin and oxytocin contents in brainstem and spinal cord of rat

1983 • 122 citations

Sildenafil Citrate, a Selective Phosphodiesterase Type 5 Inhibitor:

1999 • 121 citations

Age Decreases Nitric Oxide Synthase-Containing Nerve Fibers in the Rat Penis

1997 • 121 citations

Oxytocinergic and serotonergic innervation of identified lumbosacral nuclei controlling penile erection in the male rat

1997 • 120 citations

GABAergic control of masculine sexual behavior

1986 • 119 citations

Central neuropharmacological agents and mechanisms in erectile dysfunction: the role of dopamine

2000 • 118 citations

Microinjection of the dopamine antagonist cis-flupenthixol into the MPOA impairs copulation, penile reflexes and sexual motivation in male rats

1991 • 116 citations

THE EFFECT OF THE SPECIFIC PHOSPHODIESTERASE (PDE) INHIBITORS ON HUMAN AND RABBIT CAVERNOUS TISSUE IN VITRO AND IN VIVO

1998 • 116 citations

Pharmacotherapy for erectile dysfunction

2000 • 112 citations

Stimulation of the medial preoptic area of the hypothalamus in the rat elicits increases in intracavernous pressure

1996 • 111 citations

Effect of Long-term Passive Smoking on Erectile Function and Penile Nitric Oxide Synthase in the Rat

1997 • 111 citations

d(CH2)5Tyr(Me)-[Orn8]vasotocin, a potent oxytocin antagonist, antagonizes penile erection and yawning induced by oxytocin and apomorphine, but not by ACTH-(1–24)

1987 • 110 citations

Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II

2000 • 109 citations

Restoration of Normal Adult Penile Erectile Response in Aged Rats by Long-Term Treatment with Androgens1

1995 • 106 citations

Drug-induced penile erections in rats: indications of serotonin1B receptor mediation

1987 • 105 citations

Endothelin-1 as a Putative Modulator of Erectile Dysfunction: I. Characteristics of Contraction of Isolated Corporal Tissue Strips

1995 • 104 citations

Clinical Pharmacokinetics of Molsidomine

1996 • 104 citations

CHOLINERGIC NERVES IN HUMAN CORPUS CAVERNOSUM AND SPONGIOSUM CONTAIN NITRIC OXIDE SYNTHASE AND HEME OXYGENASE

2000 • 104 citations

Apomorphine-induced penile tumescence in impotent patients — preliminary findings

1987 • 104 citations

Microinjection of cis-flupenthixol, a dopamine antagonist, into the medial preoptic area impairs sexual behavior of male rats

1988 • 102 citations

Differential influence of a selective melanocortin MC4 receptor antagonist (HS014) on melanocortin-induced behavioral effects in rats

1998 • 101 citations

The effects of intracranial administration of the dopamine agonist apomorphine on penile reflexes and seminal emission in the rat

1989 • 101 citations

Efficacy and safety of fixed-dose and dose-optimization regimens of sublingual apomorphine versus placebo in men with erectile dysfunction

2000 • 101 citations

Penile erection induced by apomorphine and N-n-propyl-norapomorphine in rats.

1979 • 100 citations

Effect of large doses of the nitric oxide precursor, L-arginine, on erectile dysfunction.

1994 • 99 citations

Effect of apomorphine, a dopamine receptor agonist, on penile tumescence in normal subjects

1984 • 99 citations

Diminished neurogenic but not pharmacological erections in the 2- to 3-month experimentally diabetic F-344 rat

1997 • 97 citations

PRESENCE AND BIOLOGICAL ACTIVITY OF C-TYPE NATRIURETIC PEPTIDE-DEPENDENT GUANYLATE CYCLASE-COUPLED RECEPTOR IN THE PENILE CORPUS CAVERNOSUM

1998 • 97 citations

Actions of endothelin on isolated corpus cavernosum from rabbit and man

1990 • 96 citations

Selective effects of β-endorphin infused into the hypothalamus, preoptic area and bed nucleus of the stria terminalis on the sexual and ingestive behaviour of male rats

1987 • 96 citations

Cloning of a Novel Neuronal Nitric Oxide Synthase Expressed in Penis and Lower Urinary Tract

1996 • 96 citations

Role op central nitric oxide in the control of penile erection and yawning

1997 • 95 citations

ORAL PHENTOLAMINE AS TREATMENT FOR ERECTILE DYSFUNCTION

1998 • 94 citations

Changes in the Vipergic, Cholinergic and Adrenergic Innervation of Human Penile Tissue in Diabetic and Non-Diabetic Impotent Males

1987 • 94 citations

ROLE OF BRADYKININ IN THE NEONATAL RENAL EFFECTS OF ANGIOTENSIN CONVERTING ENZYME INHIBITION

1997 • 94 citations

DECREASE OF VASOACTIVE INTESTINAL POLYPEPTIDE (VIP) IN THE PENISES FROM IMPOTENT MEN

1984 • 94 citations

Evidence that apomorphine induces penile erection and yawning by releasing oxytocin in the central nervous system

1989 • 94 citations

Neurotransmission and the contraction and relaxation of penile erectile tissues

1997 • 94 citations

The biochemical and neurologic basis for the treatment of male erectile dysfunction.

2001 • 93 citations

Effects of lesions in the hypothalamic paraventricular, supraoptic and suprachiasmatic nuclei on vasopressin and oxytocin in rat brain and spinal cord

1985 • 93 citations

Androgens modulate the alpha-adrenergic responsiveness of vascular smooth muscle in the corpus cavernosum.

1997 • 93 citations

Effects of D2-dopaminergic receptor stimulation on male rat sexual behavior

1987 • 93 citations

Double Blind Trial of Yohimbine Hydrochloride in the Treatment of Erection Inadequacy

1989 • 92 citations

5-Hydroxytryptamine2C receptors on spinal neurons controlling penile erection in the rat

1999 • 91 citations

Pharmacotherapy of erectile dysfunction

2021 • 91 citations

Stimulation of spinal serotonergic receptors facilitates seminal emission and suppresses penile erectile reflexes

1985 • 89 citations

Adrenergic alpha receptors outnumber beta receptors in human penile corpus cavernosum.

1980 • 89 citations

NO synthase in cholinergic nerves and NO‐induced relaxation in the rat isolated corpus cavernosum

1999 • 89 citations

Effect of the nitric oxide level in the medial preoptic area on male copulatory behavior in rats

1998 • 87 citations

Investigative Urology

1995 • 87 citations

Systemic or intracranial apomorphine increases copulation in long-term castrated male rats

1990 • 87 citations

Nitrergic control of peripheral sympathetic responses in the human corpus cavernosum: A comparison with other species

1997 • 86 citations

Is Vasoactive Intestinal Polypeptide the Principal Transmitter Involved in Human Penile Erection?

1986 • 86 citations

Effect of the selective phosphodiesterase type 5 inhibitor sildenafil on erectile dysfunction in the anesthetized dog.

1998 • 86 citations

The pharmacokinetics of yohimbine in man

1987 • 85 citations

Characterization of Cyclic AMP Accumulation in Cultured Human Corpus Cavernosum Smooth Muscle Cells

1994 • 83 citations

Cloning and characterization of two splice variants of human phosphodiesterase 11A

2000 • 82 citations

Minoxidil versus Nitroglycerin: A Prospective Double-Blind Controlled Trial in Transcutaneous Erection Facilitation for Organic Impotence

1991 • 81 citations

Cloning of human prostanoid receptors

1995 • 81 citations

Combination therapy using oral alpha-blockers and intracavernosal injection in men with erectile dysfunction

1998 • 81 citations

Nitric oxide production is increased in the paraventricular nucleus of the hypothalamus of male rats during non-contact penile erections and copulation

1998 • 80 citations

Human calcitonin gene‐related peptide activates adenylate cyclase and releases prostacyclin from human umbilical vein endothelial cells

1987 • 80 citations

Effect of yohimbine-trazodone on psychogenic impotence: A randomized, double-blind, placebo-controlled study

1994 • 80 citations

Hypersexuality - a Complication of Dopaminergic Therapy in Parkinson's Disease

1983 • 79 citations

Characterization of Multiple [³H]5–Hydroxytryptamine Binding Sites in Rat Spinal Cord Tissue

1983 • 79 citations

Androgenic Maintenance of the Rat Erectile Response Via a Non‐Nitric‐Oxide‐Dependent Pathway

1997 • 79 citations

MECHANISMS OF ISCHEMIA-INDUCED CAVERNOSAL SMOOTH MUSCLE RELAXATION IMPAIRMENT IN A RABBIT MODEL OF VASCULOGENIC ERECTILE DYSFUNCTION

1998 • 79 citations

Apomorphine and haloperidol, but not domperidone, affect penile reflexes in rats

1988 • 79 citations

Gap Junctions Formed of Connexin43 Are Found Between Smooth Muscle Cells of Human Corpus Cavernosum

1993 • 79 citations

A Heterogeneous Population of Alpha sub 1 Adrenergic Receptors Mediates Contraction of Human Corpus Cavernosum Smooth Muscle to Norepinephrine

1995 • 78 citations

Erectile dysfunction in aging: upregulation of endothelial nitric oxide synthase

1998 • 78 citations

Yohimbine in erectile dysfunction: the facts

2000 • 78 citations

Renin Angiotensin System in Rabbit Corpus Cavernosum: Functional Characterization of Angiotensin II Receptors

1997 • 77 citations

Three cases of manic symptoms following yohimbine administration

1984 • 77 citations

K_ATP channels gated by intracellular nucleotides and phospholipids

2000 • 77 citations

Androgenic Maintenance of Inflow and Veno-Occlusion during Erection in the Rat

1998 • 77 citations

A double-blind, placebo-controlled evaluation of the erectile response to transurethral alprostadil

1996 • 77 citations

Effects of Castration and Exogenous Testosterone Supplementation in an Animal Model of Penile Erection

1994 • 76 citations

Age-dependent alterations in the efficacy of phenylephrine-induced contractions in vascular smooth muscle isolated from the corpus cavernosum of impotent men

1991 • 75 citations

Spinal control of penile erection

1997 • 75 citations

Topical Nitroglycerin: A Potential Treatment for Impotence

1989 • 75 citations

Human cloned α1A-adrenoceptor isoforms display α1L-adrenoceptor pharmacology in functional studies

1999 • 74 citations

EXPRESSION OF DIFFERENT PHOSPHODIESTERASE GENES IN HUMAN CAVERNOUS SMOOTH MUSCLE

2001 • 74 citations

Double-blind, placebo-controlled safety and efficacy trial with yohimbine hydrochloride in the treatment of nonorganic erectile dysfunction

1997 • 74 citations

Neuroendocrine and behavioral effects of m-chlorophenylpiperazine administration in rhesus monkeys

1984 • 73 citations

Pyrimidine and triazine 3-oxide sulfates: a new family of vasodilators

1983 • 73 citations

Diabetic Penile Neuropathy

1988 • 73 citations

Study of Etiologic Relationship of Arterial Atherosclerosis to Corporal Veno-Occlusive Dysfunction in the Rabbit

1996 • 73 citations

Nitric oxide synthase inhibitors prevent apomorphine- and oxytocin-induced penile erection and yawning in male rats

1993 • 72 citations

Release of nitric oxide from endothelial cells stimulated by YC‐1, an activator of soluble guanylyl cyclase

1999 • 72 citations

Preliminary Results with the Nitric Oxide Donor Linsidomine Chlorhydrate in the Treatment of Human Erectile Dysfunction

1992 • 72 citations

Effect of Apomorphine on Penile Tumescence in Men with Psychogenic Impotence

1991 • 72 citations

Assessment of erectogenic properties of apomorphine and yohimbine in man.

1988 • 71 citations

Impairment of corpus cavernosal smooth muscle relaxation by glycosylated human haemoglobin

2000 • 69 citations

Prostanoid Production in Rabbit Corpus Cavernosum: I. Regulation by Oxygen Tension

1996 • 69 citations

Nitric Oxide and the Cyclic GMP System in the Penis.

1999 • 69 citations

Endorphins in male impotence: Evidence for naltrexone stimulation of erectile activity in patient therapy

1989 • 68 citations

Penile Response to Intracavernosal Vasoactive Intestinal Polypeptide Alone and in Combination with Other Vasoactive Agents

1989 • 68 citations

Apomorphine: Clinical studies on erectile impotence and yawning

1989 • 68 citations

Oral phentolamine: an alpha-1, alpha-2 adrenergic antagonist for the treatment of erectile dysfunction

2000 • 68 citations

INTRACAVERNOSAL FORSKOLIN: ROLE IN MANAGEMENT OF VASCULOGENIC IMPOTENCE RESISTANT TO STANDARD 3-AGENT PHARMACOTHERAPY

1997 • 68 citations

Intracavernous Self-Injection with Vasoactive Intestinal Polypeptide and Phentolamine in the Management of Erectile Failure

1992 • 67 citations

Prejunctional alpha sub 2-Adrenoceptors Inhibit Nitrergic Neurotransmission in Horse Penile Resistance Arteries

1997 • 67 citations

Oxytocin increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats: correlation with penile erection and yawning

1997 • 67 citations

Investigative Urology: An Analysis of the Maxi-K sup + (k sub Ca) Channel in Cultured Human Corporal Smooth Muscle Cells

1995 • 67 citations

Apomorphine: an update of clinical trial results

2000 • 67 citations

ENDOTHELIN-1 IN DIABETIC AND NONDIABETIC MEN WITH ERECTILE DYSFUNCTION

1997 • 67 citations

N-Methyl-d-aspartic acid-induced penile erection and yawning: role of hypothalamic paraventricular nitric oxide

1997 • 66 citations

Evidence for the involvement of endothelial nitric oxide synthase from smooth muscle cells in the erectile function of the human corpus cavernosum

1998 • 65 citations

Depletion of brain serotonin differently affects behaviors induced by 5HT1A, 5HT1C, and 5HT2 receptor activation in rats

1991 • 65 citations

Correlations of Purinergic, Cholinergic and Adrenergic Functions in Rabbit Corporal Cavernosal Tissue

1992 • 65 citations

Neural and endothelial nitric oxide synthase activity in rat penile erectile tissue

1995 • 64 citations

Calcitonin-Gene-Related Peptide: A Possible Role in Human Penile Erection and its Therapeutic Application in Impotent Patients

1991 • 64 citations

Morphological and functional in vitro and in vivo characterization of the mouse corpus cavernosum

2001 • 64 citations

Endothelin-1 as Putative Modulator of Erectile Dysfunction. II. Calcium Mobilization in Cultured Human Corporal Smooth Muscle Cells

1995 • 63 citations

A Clinical Trial of Intracavernous Vasoactive Intestinal Peptide to Induce Penile Erection

1990 • 63 citations

Viagra—after one year

1999 • 62 citations

The role of gap junctions and ion channels in the modulation of electrical and chemical signals in human corpus cavernosum smooth muscle.

1993 • 62 citations

α2Adrenergic and Opiate Receptor Blockade

1986 • 61 citations

Oxytocin Stimulation of Penile Erection

1992 • 61 citations

Modification of sexual behavior of Long–Evans male rats by drugs acting on the 5-HT1A receptor

1999 • 61 citations

Concentrations of gaba and glycine in discrete brain nuclei Stress-induced changes in the levels of inhibitory amino acids

1986 • 61 citations

The density and distribution of endothelin 1 and endothelin receptor subtypes in normal and diabetic rat corpus cavernosum

1995 • 61 citations

Trazodone, a double blind trial for treatment of erectile dysfunction

1997 • 61 citations

Prostaglandin E1 activates the large-conductance KCa channel in human corporal smooth muscle cells

1999 • 60 citations

Role of the nitric oxide donor linsidomine chlorhydrate (SIN-1) in the diagnosis and treatment of erectile dysfunction

1994 • 60 citations

Sexual behavior in heroin addiction and methadone maintenance. Correlation with plasma luteinizing hormone.

1972 • 60 citations

ORAL AND TOPICAL TREATMENT OF ERECTILE DYSFUNCTION

1995 • 59 citations

Direct immunocytochemical localization of 5‐hydroxytryptamine receptors in the adult rat spinal cord: A light and electron microscopic study using an anti‐idiotypic antiserum

1994 • 59 citations

Spinal monoaminergic modulation of masculine copulatory behavior in the rat

1984 • 59 citations

Localization of Androgen Receptor in Nitric Oxide Synthase‐ and Vasoactive Intestinal Peptide‐Containing Neurons of the Major Pelvic Ganglion Innervating the Rat Penis

1997 • 59 citations

Apomorphine- and Oxytocin-Induced Penile Erection and Yawning in Intact and Castrated Male Rats: Effect of Sexual Steroids

1994 • 59 citations

Effects of intrathecal administration of 8-OH-DPAT on genital reflexes and mating behavior in male rats

1990 • 59 citations

Experience with buccal phentolamine mesylate for impotence.

1994 • 59 citations

Trazodone Hydrochloride: A Wide Spectrum Antidepressant with a Unique Pharmacological Profile

1982 • 59 citations

Penile erection and yawning induced by paraventricular NMDA injection in male rats are mediated by oxytocin

1994 • 58 citations

Afferents originating from the dorsal penile nerve excite oxytocin cells in the hypothalamic paraventricular nucleus of the rat

1996 • 58 citations

Cardiovascular effects of vasoactive intestinal peptide in healthy subjects

1987 • 58 citations

Morphine injected into the paraventricular nucleus of the hypothalamus prevents noncontact penile erections and impairs copulation: involvement of nitric oxide

1999 • 58 citations

Cavernosal nerve stimulation in the rat reverses castration-induced decrease in penile NOS activity

1996 • 57 citations

Expression of Penile Neuronal Nitric Oxide Synthase Variants in the Rat and Mouse Penile Nerves1

2000 • 56 citations

EX VIVO EXPRESSION OF NITRIC OXIDE SYNTHASE ISOFORMS (eNOS/iNOS) AND CALMODULIN IN HUMAN PENILE CAVERNOSAL CELLS

1998 • 56 citations

Expression of myosin isoforms in smooth muscle cells in the corpus cavernosum penis

1998 • 55 citations

THE EFFECT OF SILDENAFIL ON APOMORPHINE-EVOKED INCREASES IN INTRACAVERNOUS PRESSURE IN THE AWAKE RAT

1999 • 55 citations

Evidence Against Involvement of Endorphins in Sexual Arousal and Orgasm in Man

1977 • 55 citations

THE EFFECTS OF ALTERATIONS IN NITRIC OXIDE LEVELS IN THE PARAVENTRICULAR NUCLEUS ON COPULATORY BEHAVIOR AND REFLEXIVE ERECTIONS IN MALE RATS

1999 • 55 citations

REPEATED PGE1 TREATMENT ENHANCES NITRIC OXIDE AND ERECTION RESPONSES TO NERVE STIMULATION IN THE RAT PENIS BY UPREGULATING CONSTITUTIVE NOS ISOFORMS

1999 • 54 citations

Analysis of the Presence and Physiological Relevance of Subconducting States of Connexin43-Derived Gap Junction Channels in Cultured Human Corporal Vascular Smooth Muscle Cells

1999 • 54 citations

Opiate-Androgen Interactions in Drug-Induced Yawning and Penile Erections in the Rat

1986 • 54 citations

Oral Phentolamine in Nonspecific Erectile Insufficiency

1988 • 53 citations

Integrative erectile biology: the role of signal transduction and cell-to-cell communication in coordinating corporal smooth muscle tone and penile erection

1997 • 53 citations

Methadone Dose and Human Sexual Behavior

1978 • 53 citations

Nitric oxide donors induce penile erection and yawning when injected in the central nervous system of male rats

1995 • 53 citations

Localization of Nitric Oxide Synthase in Spinal Nuclei Innervating Pelvic Ganglia

1995 • 52 citations

The Role of Andorgens in the Erectile Response: A 1999 Perspective.

1999 • 52 citations

Effects of Some Calcium Channel Blockers on Isolated Human Penile Erectile Tissues

1987 • 51 citations

Effects of fenfluramine, M-chlorophenylpiperazine, and other serotonin-related agonists and antagonists on penile erections in nonhuman primates

1988 • 51 citations

Phentolamine mesylate relaxes penile corpus cavernosum tissue by adrenergic and non-adrenergic mechanisms

1998 • 50 citations

A Possible Role for Calcitonin-Gene-Related Peptide in the Regulation of the Smooth Muscle Tone of the Bladder and Penis

1990 • 50 citations

Functional effects, binding sites and immunolocalization of endothelin-1 in isolated penile tissues from man and rabbit.

1992 • 50 citations

Possible role for endothelins in penile erection

1996 • 49 citations

Is high-dose yohimbine hydrochloride effective in the treatment of mixed-type impotence? A prospective, randomized, controlled double-blind crossover study

1997 • 49 citations

Oral trazodone as empirical therapy for erectile dysfunction: a retrospective review

1995 • 49 citations

Clinical Experience with Intraurethral Alprostadil (MUSE<sup>®</sup>) in the Treatment of Men with Erectile Dysfunction

2000 • 49 citations

Characterization of ATP-sensitive potassium channels in human corporal smooth muscle cells

1999 • 49 citations

Effect of infused vasoactive intestinal peptide on airway function in normal subjects.

1986 • 49 citations

Nitric oxide synthase inhibitors prevent acid-induced penile erection and yawning in male rats

1994 • 48 citations

Specific involvement of central 5-HT1A receptors in the mediation of male rat ejaculatory behavior.

1997 • 48 citations

Effects of Intracavernosal Trazodone Hydrochloride: Animal and Human Studies

1990 • 47 citations

Receptor-specific influence of endothelin-1 in the erectile response of the rat

2000 • 47 citations

Pituitary adenylate cyclase‐activating polypeptide, helospectin, and vasoactive intestinal polypeptide in human corpus cavernosum

1995 • 47 citations

Kinetic characteristics of alpha 1-adrenergic contractions in human corpus cavernosum smooth muscle

1992 • 47 citations

Signal transduction in cavernous smooth muscle

1997 • 46 citations

N-3-Substituted Imidazoquinazolinones: Potent and Selective PDE5 Inhibitors as Potential Agents for Treatment of Erectile Dysfunction

2000 • 46 citations

Nitric oxide synthase and vasoactive intestinal polypeptide colocalization in neurons innervating the human penile circulation.

1995 • 46 citations

Dose dependent D2 effects on genital reflexes after MPOA injections of quinelorane and apomorphine

1991 • 46 citations

Suppression of the Excitatory Adrenergic Neurotransmission; a Possible Role of Cholinergic Nerves in the Retractor Penis Muscle

1977 • 46 citations

A double blind, placebo controlled study of intracavernosal vasoactive intestinal polypeptide and phenotolamine mesylate in a novel auto-injector for the treatment of non-psychogenic erectile dysfunction

1999 • 45 citations

Effect of angiotensin II on corpus cavernosum smooth muscle in relation to nitric oxide environment: in vitro studies in canines

1997 • 45 citations

Adrenoceptor-Mediated Regulation of the Contractility in Horse Penile Resistance Arteries

1997 • 45 citations

Effects of intrathecal and systemic administration of buspirone on genital reflexes and mating behavior in male rats

1990 • 44 citations

Effects of Adenosine on Canine Penile Erection

1992 • 44 citations

Coexistence of Nitric Oxide Synthase, Tyrosine Hydroxylase and Vasoactive Intestinal Polypeptide in Human Penile Tissue–a Triple Histochemical and Immunohistochemical Study

1995 • 43 citations

Identification of alpha 1-adrenergic receptor subtypes in human corpus cavernosum tissue and in cultured trabecular smooth muscle cells.

1995 • 43 citations

The effects of intrathecal administration of the dopamine agonist apomorphine on penile reflexes and copulation in the male rat

1989 • 43 citations

Neurogenic Nitric Oxide Mediates Relaxation of Canine Corpus Cavernosum

1996 • 42 citations

EFFICACY AND SAFETY OF APOMORPHINE SL VS PLACEBO FOR MALE ERECTILE DYSFUNCTION (MED)

1999 • 42 citations

Dopamine-stimulated sexual behavior is testosterone dependent in mice.

1998 • 42 citations

A therapeutic taxonomy of treatments for erectile dysfunction: an evolutionary imperative

1997 • 42 citations

Prevention by NG-nitro-L-arginine methyl ester of apomorphine- and oxytocin-induced penile erection and yawning: site of action in the brain

1994 • 42 citations

Nitric oxide is a central mediator of penile erection

1994 • 42 citations

Investigative Urology: Modulation of Vasoactive Intestinal Polypeptide (VIP)-Mediated Relaxation by Nitric Oxide and Prostanoids in the Rabbit Corpus Cavernosum

1995 • 42 citations

Safety of Intracavernous Injections using an Alpha-Blocking Agent

1989 • 41 citations

Prostaglandin E1 and the Nitric Oxide Donor Linsidomine for Erectile Failure: A Diagnostic Comparative Study of 40 Patients

1993 • 41 citations

Followup Results of a Combination of Calcitonin Gene-Related Peptide and Prostaglandin E1 in the Treatment of Erectile Dysfunction

1993 • 41 citations

Erectogenic effect of the selective phosphodiesterase type 5 inhibitor, DA-8159

2000 • 41 citations

Forskolin: A Promising New Adjunct to Intracavernous Pharmacotherapy

1996 • 41 citations

Vasomax for the treatment of male erectile dysfunction

2001 • 39 citations

Brain localization of cholinergic influence on male sex behavior in rats: Agonists

1988 • 39 citations

Gene Expression of the Phosphodiesterases 3A and 5A in Human Corpus cavernosum Penis

2000 • 39 citations

The role of prostaglandins in the aetiology and treatment of erectile dysfunction

1999 • 39 citations

Comparison of the effects of different isomers of bicuculline infused in the preoptic area on male rat sexual behavior

1985 • 39 citations

Nociceptin, a novel endogenous ligand for the ORL1 receptor, has potent erectile activity in the cat

1997 • 39 citations

A pilot study of the role of intracavernous injection of vasoactive intestinal peptide (VIP) and phentolamine mesylate in the treatment of erectile dysfunction.

1996 • 38 citations

Vasoactive intestinal polypeptide and phentolamine mesylate administered by autoinjector in the treatment of patients with erectile dysfunction resistant to other intracavernosal agents

1998 • 38 citations

Serotonergic influences on male sexual behavior of rhesus monkeys: effects of serotonin agonists

1993 • 38 citations

STUDIES ON THE MECHANISMS INVOLVED IN THE ATP-INDUCED RELAXATION IN HUMAN AND RABBIT CORPUS CAVERNOSUM

1999 • 38 citations

Diabetes mellitus increases nitric oxide synthase in penises but not in major pelvic ganglia of rats

1995 • 37 citations

Expression of functional muscarinic acetylcholine receptor subtypes in human corpus cavernosum and in cultured smooth muscle cells.

1995 • 37 citations

Investigative Urology

1995 • 37 citations

POTENTIATION OF ERECTILE RESPONSE AND cAMP ACCUMULATION BY COMBINATION OF PROSTAGLANDIN E₁AND ROLIPRAM, A SELECTIVE INHIBITOR OF THE TYPE 4 PHOSPHODIESTERASE (PDE 4)

1999 • 37 citations

Septohippocampal cholinergic pathway and penile erections induced by dopaminergic and cholinergic stimulants

1990 • 37 citations

Adrenergic Receptors on Smooth Muscle Cells Isolated from Human Penile Corpus Cavernosum

1993 • 37 citations

Prevention by morphine of apomorphine- and oxytocin-induced penile erection and yawning: involvement of nitric oxide

1997 • 37 citations

Spinal proerectile effect of apomorphine in the anesthetized rat

2001 • 36 citations

Opposite influences of dopaminergic receptor subtypes on penile erection

1992 • 36 citations

Regulation of pre-synaptic alpha adrenergic activity in the corpus cavernosum

2000 • 36 citations

Prostanoid production in rabbit corpus cavernosum. II. Inhibition by oxidative stress.

1996 • 36 citations

Pharmacodynamic effects of chronic yohimbine treatment in healthy volunteers

1990 • 36 citations

Intracavernous Calcitonin Gene-Related Peptide Plus Prostaglandin E(1): Possible Alternative to Penile Implants in Selected Patients

1994 • 36 citations

ERECTILE RESPONSE TO TRANSURETHRAL ALPROSTADIL, PRAZOSIN AND ALPROSTADIL-PRAZOSIN COMBINATIONS

1998 • 36 citations

Preliminary report on the effect of the nitric oxide donor SIN-1 on human cavernous tissue in vivo

1991 • 36 citations

Gap junctions and ion channels: relevance to erectile dysfunction

2000 • 35 citations

STIMULATION OF P2y PURINOCEPTORS INDUCES, VIA NITRIC OXIDE PRODUCTION, ENDOTHELIUM-DEPENDENT RELAXATION OF HUMAN ISOLATED CORPUS CAVERNOSUM

1999 • 35 citations

Soluble guanylate cyclase and cGMP-dependent protein kinase I expression in the human corpus cavernosum

2000 • 34 citations

Effects of opioid blockade with nalmefene in older impotent men

1990 • 34 citations

G-protein-coupled receptor agonists augment adenylyl cyclase activity induced by forskolin in human corpus cavernosum smooth muscle cells.

1997 • 33 citations

DHOBIE MARK DERMATITIS

1943 • 33 citations

Transcutaneous Nitroglycerin Therapy in the Treatment of Impotence

1989 • 33 citations

Melatonin enhances sexual behavior in the male rat

2000 • 33 citations

Effects of papaverine and vasointestinal polypeptide on penile and vascular cAMP and cGMP in control and diabetic animals: an in vitro study.

1995 • 33 citations

Effects of purines on rabbit corpus cavernosum contractile activity.

1993 • 33 citations

mRNA and protein expression of nitric oxide synthase and adrenoceptor alpha 1 in young and old rat penile tissues

1997 • 33 citations

Evidence against vasoactive intestinal polypeptide as the relaxant neurotransmitter in human cavernosal smooth muscle

1993 • 32 citations

Androgenic maintenance of the erectile response in the rat

1999 • 32 citations

Effectiveness of yohimbine in the treatment of erectile disorder: Four meta-analytic integrations

1996 • 32 citations

Autoradiographic Localization of Nitric Oxide Synthase Binding Sites in Normal and Diabetic Rat Corpus Cavernosum

1996 • 32 citations

Expression of functional alpha2-adrenergic receptor subtypes in human corpus cavernosum and in cultured trabecular smooth muscle cells.

1997 • 32 citations

Nitric oxide is involved in the ACTH-induced behavioral syndrome

1995 • 32 citations

Opiate Antagonists in Erectile Dysfunction: A Possible New Treatment Option?

1995 • 32 citations

Prevention by Morphine of N-Methyl-d-Aspartic Acid-Induced Penile Erection and Yawning: Involvement of Nitric Oxide

1997 • 32 citations

NORADRENALINE RELEASE IN HUMAN CORPUS CAVERNOSUM AND ITS MODULATION VIA PRESYNAPTIC α₂‐ADRENOCEPTORS

1989 • 31 citations

CHARACTERIZATION OF α-ADRENOCEPTOR SUBTYPES IN THE CORPUS CAVERNOSUM OF PATIENTS UNDERGOING SEX CHANGE SURGERY

1999 • 31 citations

Non‐invasive Management of Impotence with Transcutaneous Nitroglycerin

1992 • 31 citations

Sexual Aspects of Drug Abuse in Narcotic Addicts*

1976 • 31 citations

Ion Channels and Gap Junctions: Their Role in Erectile Physiology, Dysfunction, and Future Therapy.

1999 • 31 citations

The Potent Relaxant Effect of Adenosine in Rabbit Corpora Cavernosa Is Nitric Oxide Independent and Mediated by A₂ Receptors

1995 • 30 citations

Central Nervous System Pathways Involved in the Control of Penile Erection

1999 • 30 citations

Comparison of Responses to Adrenomedullin and Calcitonin Gene‐Related Peptide in the Feline Erection Model

1997 • 30 citations

Activation of γ-aminobutyric acidA receptors in the paraventricular nucleus of the hypothalamus reduces apomorphine-, N-methyl-d-aspartic acid- and oxytocin-induced penile erection and yawning in male rats

2000 • 30 citations

Synthetic nitrovasodilators are effective, in vitro, in relaxing penile tissue from impotent men: the findings and their implications

1989 • 30 citations

Prevention by morphine of apomorphine- and oxytocin-induced penile erection and yawning: site of action in the brain.

1992 • 30 citations

EFFECTS OF AN ENVIRONMENTAL ANTI-ANDROGEN ON ERECTILE FUNCTION IN AN ANIMAL PENILE ERECTION MODEL

2000 • 30 citations

ω-Conotoxin prevents apomorphine- and oxytocin-induced penile erection and yawning in male rats

1990 • 30 citations

Affinity of trazodone for human penile α₁‐ andα₂‐adrenoceptors

2000 • 29 citations

Male sexual arousal with repeated exposure to erotic stimuli

1984 • 29 citations

Quinelorane (LY163502), a D2 dopamine receptor agonist, acts centrally to facilitate penile erections of male rhesus monkeys

1991 • 29 citations

Sexuality and Impotence in the Aging Man

1991 • 29 citations

Design and evaluation of nitrosylated alpha-adrenergic receptor antagonists as potential agents for the treatment of impotence.

1999 • 29 citations

PATTERNS OF MESSENGER RNA EXPRESSION FOR alpha _{1-ADRENOCEPTOR} SUBTYPES IN HUMAN CORPUS CAVERNOSUM

1998 • 28 citations

Recombinant saphenous vein 5‐HT_1B receptors of the rabbit: comparative pharmacology with human 5‐HT_1B receptors

1997 • 28 citations

Central noradrenergic control of penile erection

2000 • 28 citations

Comparative studies of the maxi-K (KCa) channel in freshly isolated myocytes of human and rat corpora

2000 • 28 citations

Acute low doses of melatonin stimulate rat sex behavior: the role of serotonin neurotransmission

1999 • 27 citations

Regulation of actomyosin and contraction in smooth muscle

1994 • 27 citations

The ?syncytial tissue triad?: a model for understanding how gap junctions participate in the local control of penile erection

1997 • 27 citations

Vasoactive intestinal polypeptide (VIP) and peptide histidine methionine (PHM) in human penile corpus cavernosum tissue and circumflex veins: localization and in vitro effects

1992 • 26 citations

Adrenomedullin induces penile erection in the cat

1997 • 26 citations

Effect of moxisylyte hydrochloride on isolated human penile corpus cavernosum tissue

1989 • 26 citations

PLASMA LEVELS OF CAVERNOUS AND SYSTEMIC NOREPINEPHRINE AND EPINEPHRINE IN MEN DURING DIFFERENT PHASES OF PENILE ERECTION

2000 • 26 citations

Different effects of ω-conotoxin on penile erection, yawning and paraventricular nitric oxide in male rats

1998 • 26 citations

On the putative mechanistic basis for intraoperative propofol-induced penile erections

1997 • 26 citations

Role of the Dopaminergic, Serotonergic and Cholinergic Link in the Expression of Penile Erection in Rats

1994 • 25 citations

Transcutaneous nitroglycerin in the treatment of erectile dysfunction in spinal cord injured

1992 • 25 citations

Phospholipase C Activation by Endothelin-1 and Noradrenaline in Isolated Penile Erectile Tissue from Rabbit

1992 • 25 citations

IN VIVO AND IN VITRO INVESTIGATION OF THE EFFECTS OF SILDENAFIL ON RAT CAVERNOUS SMOOTH MUSCLE

2001 • 25 citations

Nitric oxide-synthesizing neurons originating at several different levels innervate rat penis

1996 • 25 citations

Localization and effects of pituitary adenylate cyclase‐activating polypeptide (PACAP) in human penile erectile tissue

1994 • 25 citations

New Treatments for Erectile Impotence

1992 • 24 citations

Distribution and function of nitric oxide‐containing nerves in canine corpus cavernosum and spongiosum

1995 • 24 citations

Endothelial and neuronal-derived nitric oxide mediated relaxation of corpus cavernosal smooth muscle in a rat, in vitro, model of erectile function

2000 • 24 citations

Vasoactive Intestinal Polypeptide and Phentolamine Mesylate Administered by Autoinjector in the Treatment of Patients With Erectile Dysfunction Resistant to Other Intracavernosal Agents

1998 • 23 citations

Developmental status of topical therapies for erectile and ejaculatory dysfunction

2000 • 23 citations

Functional Characterization of Endothelin Receptors in the Bovine Retractor Penis Muscle and Penile Artery

1996 • 23 citations

Eicosanoids, erections and erectile dysfunction

1994 • 23 citations

Trazodone: a double-blind, placebo-controlled, randomized study of its effects in patients with erectile dysfunction without major organic findings

2000 • 23 citations

Oral pharmacotherapy for erectile dysfunction: current perspectives

1999 • 23 citations

Potentiation of penile tumescence by T-1032, a new potent and specific phosphodiesterase type V inhibitor, in dogs.

2000 • 22 citations

Effects of intracavernous administration of selective antagonists of alpha(1)-adrenoceptor subtypes on erection in anesthetized rats and dogs.

2000 • 22 citations

Non‐surgical management of erectile dysfunction

2000 • 22 citations

Possible involvement of the septo-hippocampal cholinergic and raphe-hippocampal serotonergic activations in the penile erection induced by fenfluramine in rats

1994 • 22 citations

Role of Cyclic Adenosine Monophosphate in Prostaglandin E(1)-lnduced Penile Erection in Rabbits

1995 • 22 citations

Vasoactive intestinal peptide and impotence in experimental diabetes mellitus

1996 • 21 citations

Neuropeptides in the Human Penis: An Immunohistochemical Study

1994 • 21 citations

Denervation-induced changes in perineuronal plexuses in the major pelvic ganglion of the rat: immunohistochemistry for vasoactive intestinal polypeptide and tyrosine hydroxylase and histochemistry for NADPH-diaphorase

1997 • 21 citations

The Effect of Papaverine on Arterial and Venous Hemodynamics of Erection

1987 • 21 citations

Rationale for the combination of PGE(1) and S-nitroso-glutathione to induce relaxation of human penile smooth muscle.

2000 • 20 citations

Effect of Phentolamine on Venous Return in Human Erection

1989 • 20 citations

Preliminary Results of a Comparative Study with Intracavernous Sodium Nitroprusside and Prostaglandin E1 in Patients with Erectile Dysfunction

1995 • 20 citations

INCREASES IN INTRACAVERNOUS PENILE PRESSURE FOLLOWING INJECTIONS OF EXCITATORY AMINO ACID RECEPTOR AGONISTS IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS OF ANESTHETIZED RATS

2000 • 20 citations

Intracavernous pharmacotherapy: comparison of Moxisylyte and prostaglandin E1.

1996 • 20 citations

Endothelin-1-induced modulation of contractile responses elicited by an alpha 1-adrenergic agonist on human corpus cavernosum smooth muscle.

1996 • 19 citations

Effect of vasoactive intestinal peptide and acetylcholine on penile erection in the rat in vivo.

1995 • 19 citations

P‐chlorophenylallanine Facilitates Copulatory Behavior in Septal Lesioned but not in Preoptic Lesioned Male Rats

1993 • 19 citations

Prospective Comparative Study with Intracavernous Sodium Nitroprusside and Prostaglandin E<sub>1</sub> in Patients with Erectile Dysfunction

1998 • 18 citations

Identification of a down-regulated mRNA transcript in corpus cavernosum from diabetic patients with erectile dysfunction.

1996 • 18 citations

Apomorphine, deprenyl, and yohimbine fail to increase sexual behavior in rhesus males.

1989 • 18 citations

Localization of NADPH Diaphorase and Vasoactive Intestinal Polypeptide-Containing Neurons in the Efferent Pathway to the Rat Corpus cavernosum

1997 • 18 citations

Serotonin and sexual behavior in the male rabbit

2000 • 17 citations

The role of prostaglandins in penile erection

2000 • 17 citations

Minoxidil versus nitroglycerine: a prospective, double-blind, controlled trial in transcutaneous therapy for organic impotence.

1994 • 17 citations

Comparison of transdermal nitroglycerin and intracavernous injection of papaverine in the treatment of erectile dysfunction in patients with spinal cord lesions

1997 • 17 citations

Difference in the actions of calcitonin gene‐related peptide on pig detrusor and vesical arterial smooth muscle

1991 • 17 citations

[The peripheral pharmacology of erection].

1997 • 16 citations

Comparison of the Effects of Prostanoids on Human Penile Circumflex Veins and Corpus Cavernosum Tissue

1993 • 16 citations

Oxytocin-induced penile erection and yawning: Role of calcium and prostaglandins

1990 • 16 citations

Moxisylyte: A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in impotence

1998 • 16 citations

Drug utilization by the 30–64 year-old people in two cities in the Federal Republic of Germany in 1984

1990 • 15 citations

Hemodynamic Improvement following a Single Dose of Oral Phentolamine

1979 • 15 citations

Neuroeffector transmission to different layers of smooth muscle in the rat penile bulb

2000 • 15 citations

IP3 receptors. Ligand-activated calcium channels in multiple forms.

1992 • 15 citations

Non-synergistic relaxant effects of vasoactive intestinal polypeptide and SIN-1 in human isolated cavernous artery and corpus cavernosum

1995 • 14 citations

Effect of excitatory amino acid receptor antagonists on apomorphine-, oxytocin- and ACTH-induced penile erection and yawning in male rats

1992 • 14 citations

Molecular studies of human connexin 43 (Cx43) expression in isolated corporal tissue strips and cultured corporal smooth muscle cells

1998 • 14 citations

Peptide histidine methionine (PHM) and the human male genitalia

1985 • 13 citations

Apomorphine- and oxytocin-induced penile erection and yawning in male rats: Effect of pertussis toxin

1992 • 13 citations

Presence of Gonadotropin‐Releasing Hormone (GnRH) mRNA in Rathke’s Pouch and Effect of the GnRH‐Antagonist ORG 30276 on Lactotroph Development

1998 • 13 citations

A stretch-sensitive Cl− channel in human corpus cavernosal myocytes

1999 • 13 citations

Diabetic rats are unresponsive to the penile erection-inducing effect of intracerebroventricularly injected adrenocorticotropin

1998 • 12 citations

EFFECTS OF IC351 ON ERECTILE RESPONSE TO VISUAL SEXUAL STIMULATION

1999 • 12 citations

Molecular biological characterization of phosphodiesterase 3A from human corpus cavernosum

1999 • 12 citations

Effect of Vasoactive Intestinal Peptide in Man

1988 • 12 citations

Oral Therapy with Phentolamine in Chronic Congestive Heart Failure

1979 • 12 citations

Detection of m2 muscarinic acetylcholine receptor mRNA in human corpus cavernosum by in-situ hybridization

1994 • 11 citations

Comparison of oral and intracavernosal vasoactive agents in penile erection

2000 • 11 citations

Multiple types of ion channels in cavernous smooth muscle

1997 • 11 citations

Liver function and pharmacokinetics of molsidomine and its metabolite 3-morpholinosydnonimine in healthy volunteers.

1986 • 11 citations

Interaction of aminoalkylcarbamates of forskolin with adenylyl cyclase: synthesis of an iodinated derivative of forskolin with high affinity for adenylyl cyclase.

1992 • 10 citations

Systemic and cavernous plasma levels of endothelin 1 in healthy males during different functional conditions of the penis

2000 • 10 citations

Calcitonin gene-related peptide: immunohistochemical localization in and effects on bovine penile artery

1990 • 9 citations

Prostaglandin E<sub>1</sub> versus Linsidomine Chlorhydrate in Erectile Dysfunction

1994 • 9 citations

THE ROLE OF PROSTAGLANDIN E AS DETERMINED BY EXPRESSION OF FUNCTIONAL PROSTAGLANDIN E RECEPTORS IN HUMAN CORPUS CAVERNOSUM

1999 • 9 citations

EFFICACY OF APOMORPHINE SL VS PLACEBO FOR ERECTILE DYSFUNCTION IN PATIENTS WITH HYPERTENSION

1999 • 9 citations

Effect of Intracavernosal Sodium Nitroprusside in Impotence

1996 • 8 citations

The loss of alpha-adrenergic effect during the erectile response in the long-term diabetic rat.

1998 • 8 citations

Pharmacology of erection: Agents which initiate and terminate erection

1994 • 7 citations

The Endothelin ETB Receptor Agonist [125I]BQ-3020 Binds Predominantly to Nerves in the Bovine Retractor Penis Muscle and Penile Artery

2000 • 7 citations

The Carboxy‐Terminal Glycopeptide of the Vasopressin Precursor in the Guinea‐Pig: Release Studies Using a Specific and Sensitive Homologous Radioimmunoassay

1989 • 7 citations

Intracavernosal endothelin levels of impotent men before and after papaverine induced penile erection.

1998 • 5 citations

Effects of naloxone on penile erection in cats

1988 • 4 citations

[Prolonged use of moxisylyte chlorhydrate (Icavex) by intracavernous self-injections in the treatment of impotence. Evaluation of long-term tolerance].

1996 • 4 citations

Erectile response on visual sexual stimulation after 20 mg or 40 mg BAY 38-9456 or placebo

2000 • 3 citations