The orphan opioid receptor and its endogenous ligand — nociceptin/orphanin FQ

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

1995 • 1,887 citations

Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor

1995 • 1,800 citations

Cloning of a Delta Opioid Receptor by Functional Expression

1992 • 1,225 citations

ORL1, a novel member of the opioid receptor family

1994 • 1,060 citations

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

1975 • 981 citations

Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type

1994 • 593 citations

The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties

1982 • 509 citations

Dynorphin1–8 and dynorphin1–9 are ligands for the κ-subtype of opiate receptor

1982 • 448 citations

cDNA cloning and regional distribution of a novel member of the opioid receptor family

1994 • 404 citations

cDNA Cloning of an orphan opiate receptor gene family member and its splice variant

1994 • 379 citations

Orphanin FQ is a functional anti-opioid peptide

1996 • 369 citations

Molecular biology of the opioid receptors: structures, functions and distributions

1995 • 345 citations

Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family

1994 • 333 citations

Immunohistochemical localization of ORL-1 in the central nervous system of the rat

1996 • 283 citations

Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned μ, δ, and κ opioid receptors

1994 • 254 citations

Molecular Cloning of a Novel G Protein‐Coupled Receptor Related to the Opiate Receptor Family

1995 • 249 citations

Nociceptin/Orphanin FQ Microinjected into Hippocampus Impairs Spatial Learning in Rats

1997 • 240 citations

Increase by the ORL₁ receptor (opioid receptor‐like₁) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones

1996 • 231 citations

Bidirectional modulatory effect of orphanin FQ on morphine‐induced analgesia: antagonism in brain and potentiation in spinal cord of the rat

1997 • 230 citations

Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro

1996 • 223 citations

Functional antagonism of μ-, δ- and κ-opioid antinociception by orphanin FQ

1996 • 220 citations

Nociceptin or antinociceptin: potent spinal antinociceptive effect of orphanin FQ/nociceptin in the rat.

1996 • 217 citations

The effect of nociceptin on Ca²⁺ channel current and intracellular Ca²⁺ in the SH‐SY5Y human neuroblastoma cell line

1996 • 208 citations

Structure-Activity Relationship Studies on the Novel Neuropeptide Orphanin FQ

1996 • 196 citations

Modulation of Voltage-Gated Calcium Channels by Orphanin FQ in Freshly Dissociated Hippocampal Neurons

1996 • 181 citations

Intracerebroventricular orphanin FQ/Nociceptin supresses dopamine release in the nucleus accumbens of anaesthetized rats

1996 • 171 citations

Mapping of opioid receptors using antisense oligodeoxynucleotides: correlating their molecular biology and pharmacology

1995 • 170 citations

Actions of the ORL1 receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro.

1997 • 170 citations

Actions of the ORL₁Receptor Ligand Nociceptin on Membrane Properties of Rat Periaqueductal Gray NeuronsIn Vitro

1997 • 151 citations

Cloning and functional characterization through antisense mapping of a kappa 3-related opioid receptor.

1995 • 150 citations

Orphanin FQ: Receptor binding and analog structure activity relationships in rat brain

1996 • 147 citations

The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion

1996 • 144 citations

Nociceptin stimulates locomotion and exploratory behaviour in mice

1996 • 140 citations

Recognition and activation of the opioid receptor-like ORL1 receptor by nociceptin, nociceptin analogs and opioids

1997 • 138 citations

Orphanin FQ acts as a supraspinal, but not a spinal, anti-opioid peptide

1996 • 137 citations

Inhibitory action of nociceptin on spinal dorsal horn neurones of the rat, in vivo

1996 • 133 citations

Rats rapidly develop tolerance to the locomotor-inhibiting effects of the novel neuropeptide orphanin FQ

1996 • 132 citations

Nociceptin/orphanin FQ and opioid peptides show overlapping distribution but not co-localization in pain-modulatory brain regions

1996 • 131 citations

The mouse vas deferens: a pharmacological preparation sensitive to nociceptin

1996 • 131 citations

Nociceptin induced inhibition of K⁺ evoked glutamate release from rat cerebrocortical slices

1996 • 128 citations

Naloxone sensitive orphanin FQ-induced analgesia in mice

1996 • 125 citations

Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide

1996 • 122 citations

Structure and Chromosomal Mapping of Genes for the Mouse κ-Opioid Receptor and an Opioid Receptor Homologue (MOR-C)

1994 • 116 citations

Nociceptin/Orphanin FQ Metabolism: Role of Aminopeptidase and Endopeptidase 24.15

1997 • 113 citations

Biochemical Evidence for Orphanin FQ/Nociceptin Receptor Heterogeneity in Mouse Brain

1997 • 110 citations

Orphanin FQ/nociceptin- immunoreactive nerve fibers parallel those containing endogenous opioids in rat spinal cord

1996 • 104 citations

Depression of glutamatergic transmission by nociceptin in the neonatal rat hemisected spinal cord preparation in vitro

1996 • 104 citations

Identification and characterization of an endogenous ligand for opioid receptor homologue ROR-C: its involvement in allodynic response to innocuous stimulus

1996 • 99 citations

Moving from the Orphanin FQ Receptor to an Opioid Receptor Using Four Point Mutations

1996 • 82 citations

Naloxone‐insensitive inhibition of acetylcholine release from parasympathetic nerves innervating guinea‐pig trachea by the novel opioid, nociceptin

1997 • 80 citations

Determination of activity for nociceptin in the mouse vas deferens

1996 • 75 citations

Functional selectivity of orphanin FQ for its receptor coexpressed with potassium channel subunits in Xenopus laevis oocytes.

1996 • 72 citations

Sensitivity of Opioid Receptor-like Receptor ORL1 for Chemical Modification on Nociceptin, a Naturally Occurring Nociceptive Peptide

1996 • 72 citations

Contrast between effects of aminobisphosphonates and non‐aminobisphosphonates on collagen‐induced arthritis in mice

1996 • 70 citations

Nociceptin (orphanin FQ), an endogenous ligand for the QRL1 (opioid-receptor-like1) receptor; modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli

1996 • 62 citations

Identification of Dynorphins as Endogenous Ligands for an Opioid Receptor-like Orphan Receptor

1995 • 49 citations

Influence of the endothelium and nitric oxide on the contractile responses evoked by 5‐HT_1D receptor agonists in the rabbit isolated saphenous vein

1996 • 49 citations

Inhibition by nociceptin of the light‐evoked release of ACh from retinal cholinergic neurones

1997 • 33 citations

Pronociceptive effects of the neuropeptide, nociceptin, in the land snail, Cepaea nemoralis

1996 • 32 citations

Pasternak and standifer reply

1996 • 6 citations