The v-sis oncogene product but not platelet-derived growth factor (PDGF) A homodimers activate PDGF alpha and beta receptors intracellularly and initiate cellular transformation.

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

A C-terminal signal prevents secretion of luminal ER proteins

1987 • 2,189 citations

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

1983 • 1,657 citations

Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

1983 • 1,550 citations

Autocrine Secretion and Malignant Transformation of Cells

1980 • 1,370 citations

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

1986 • 1,244 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Perturbation of vesicular traffic with the carboxylic ionophore monensin

1983 • 890 citations

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

1986 • 786 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

1987 • 670 citations

Association between the PDGF receptor and members of the src family of tyrosine kinases

1990 • 650 citations

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1991 • 641 citations

Isolation of a Novel Receptor cDNA Establishes the Existence of Two PDGF Receptor Genes

1989 • 610 citations

Two Classes of PDGF Receptor Eecognize Different Isoforms of PDGF

1988 • 603 citations

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1991 • 585 citations

PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

1990 • 561 citations

Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types.

1988 • 514 citations

Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

1989 • 513 citations

PDGF induction of tyrosine phosphorylation of GTPase activating protein

1989 • 478 citations

Binding of GAP to Activated PDGF Receptors

1990 • 396 citations

The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor.

1984 • 376 citations

Polypeptide Growth Factors: Roles In Normal And Abnormal Cell Growth

1987 • 339 citations

Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF cell-surface receptors

1984 • 277 citations

Autocrine Stimulation of Intracellular PDGF Receptors in v- sis -Transformed Cells

1988 • 267 citations

Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells.

1989 • 262 citations

Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C.

1989 • 235 citations

Platelet-Derived Growth Factor (PDGF)-Dependent Association of Phospholipase C-γ with the PDGF Receptor Signaling Complex

1990 • 204 citations

Identification and Structural Analysis of the A Type Receptor for Platelet-derived Growth Factor

1989 • 179 citations

Comparison of Biological Properties and Transforming Potential of Human PDGF-A and PDGF-B Chains

1988 • 178 citations

Transformation by v- sis Occurs by an Internal Autoactivation Mechanism

1989 • 171 citations

Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor

1984 • 170 citations

Rapid turnover of the platelet-derived growth factor receptor in sis-transformed cells and reversal by suramin. Implications for the mechanism of autocrine transformation.

1988 • 147 citations

Phosphatidylinositol 3-Phosphate Is Present in Normal and Transformed Fibroblasts and Is Resistant to Hydrolysis by Bovine Brain Phospholipase C II

1989 • 137 citations

Processing of the platelet-derived growth factor receptor. Biosynthetic and degradation studies using anti-receptor antibodies.

1987 • 110 citations

cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains

1987 • 99 citations

Molecular cloning and comparative analyses of the genomes of simian sarcoma virus and its associated helper virus.

1981 • 81 citations

Expression of recombinant platelet-derived growth factor A- and B-chain homodimers in rat-1 cells and human fibroblasts reveals differences in protein processing and autocrine effects.

1988 • 71 citations

Nucleotide sequence of transforming human c-siscDNA clones with homology to platelet-derived growth factor

1985 • 68 citations

Autocrine stimulation by the v-sis gene product requires a ligand-receptor interaction at the cell surface.

1988 • 64 citations

Molecular Localization of the Transforming and Secretory Properties of PDGF A and PDGF B

1990 • 60 citations

Intracellular turnover, novel secretion, and mitogenically active intracellular forms of v-sis gene product in simian sarcoma virus-transformed cells. Implications for intracellular loop autocrine transformation.

1990 • 39 citations

Cell surface expression of membrane-anchored v-sis gene products: glycosylation is not required for cell surface transport.

1986 • 32 citations