Platelet-derived Growth Factor (PDGF) Receptor-α Activates c-Jun NH2-terminal Kinase-1 and Antagonizes PDGF Receptor-β-induced Phenotypic Transformation

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor

1999 • 2,386 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

1983 • 1,657 citations

Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

1983 • 1,550 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites

1997 • 706 citations

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1992 • 692 citations

Isolation of a Novel Receptor cDNA Establishes the Existence of Two PDGF Receptor Genes

1989 • 610 citations

Increasing Complexity of the Ras Signaling Pathway

1998 • 585 citations

Platelet-derived growth factor receptor signals.

1994 • 561 citations

The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases

1997 • 507 citations

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein.

1996 • 453 citations

Transcriptional regulation by MAP kinases

1995 • 431 citations

Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice

1999 • 430 citations

Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development

1997 • 420 citations

Paracrine PDGF-B/PDGF-Rβ signaling controls mesangial cell development in kidney glomeruli

1998 • 359 citations

Polypeptide Growth Factors: Roles In Normal And Abnormal Cell Growth

1987 • 339 citations

cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules.

1988 • 338 citations

A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA.

1996 • 250 citations

Expression of a Platelet-Derived Growth Factor-Like Protein in Simian Sarcoma Virus Transformed Cells

1983 • 246 citations

Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII.

1994 • 218 citations

Proliferation and Differentiation of Human Osteoblastic Cells Associated with Differential Activation of MAP Kinases in Response to Epidermal Growth Factor, Hypoxia, and Mechanical Stressin Vitro

1998 • 205 citations

Sphingosine‐1‐Phosphate in Cell Growth and Cell Death^a

1998 • 202 citations

Evidence for Distinct Signaling Properties and Biological Responses Induced by the PDGF Receptor α and β Subtypes

1999 • 197 citations

Activation of the JNK pathway is essential for transformation by the Met oncogene

1997 • 183 citations

Transformation of NIH 3T3 cells by a human c-sis cDNA clone

1984 • 181 citations

Comparison of Biological Properties and Transforming Potential of Human PDGF-A and PDGF-B Chains

1988 • 178 citations

Platelet-derived Growth Factor Activates p38 Mitogen-activated Protein Kinase through a Ras-dependent Pathway That Is Important for Actin Reorganization and Cell Migration

1999 • 171 citations

Transformation by v- sis Occurs by an Internal Autoactivation Mechanism

1989 • 171 citations

Requirement of Erk, but Not JNK, for Arsenite-induced Cell Transformation

1999 • 168 citations

Epidermal growth factor-mediated apoptosis of MDA-MB-468 human breast cancer cells.

1994 • 166 citations

Constitutive Activation of c-Jun N-terminal Kinase by a Mutant Epidermal Growth Factor Receptor

1998 • 163 citations

The Jun Kinase 2 Isoform Is Preferentially Required for Epidermal Growth Factor-Induced Transformation of Human A549 Lung Carcinoma Cells

1999 • 146 citations

Transformation by v-Src: Ras-MAPK and PI3K-mTOR Mediate Parallel Pathways

1999 • 127 citations

Platelet-derived Growth Factor-BB and Thrombin Generate Positive and Negative Signals for Human Hepatic Stellate Cell Proliferation

1998 • 103 citations

The epidermal growth factor receptor and its ligands as therapeutic targets in human tumors

1996 • 102 citations

Mechanism of action of platelet-derived growth factor

1996 • 99 citations

Stress-activated protein kinases are negatively regulated by cell density

1998 • 92 citations

Comparison of Paclitaxel-, 5-Fluoro-2′-deoxyuridine-, and Epidermal Growth Factor (EGF)-induced Apoptosis

1999 • 88 citations

Identification of the Receptor-associated Signaling Enzymes That Are Required for Platelet-derived Growth Factor-AA-dependent Chemotaxis and DNA Synthesis

1999 • 87 citations

Jun NH₂-terminal kinase is constitutively activated in T cells transformed by the intracellular parasiteTheileria parva

1997 • 82 citations

Differences in substrate specificities of alpha and beta platelet-derived growth factor (PDGF) receptors. Correlation with their ability to mediate PDGF transforming functions

1993 • 79 citations

Platelet-derived growth factor receptors expressed by cDNA transfection couple to a diverse group of cellular responses associated with cell proliferation.

1988 • 73 citations

Platelet-derived growth factor induces apoptosis in growth-arrested murine fibroblasts.

1995 • 71 citations

Differential Involvement of MEK Kinase 1 (MEKK1) in the Induction of Apoptosis in Response to Microtubule-targeted Drugsversus DNA Damaging Agents

1999 • 71 citations

Requirement of Phosphatidylinositol-3 Kinase for Activation of JNK/SAPKs by PDGF

1997 • 69 citations

Survival factors, intracellular signal transduction, and the activation of endonucleases in apoptosis

1995 • 67 citations

Tyrosine Phosphatase SHP-2 Is Involved in Regulation of Platelet-derived Growth Factor-induced Migration

1999 • 64 citations

Roles of sphingosine-1-phosphate in cell growth, differentiation, and death.

1998 • 63 citations

A dual function for p38 MAP kinase in hematopoietic cells: involvement in apoptosis and cell activation

1999 • 60 citations

Activation of c-Jun N-Terminal Kinase 1 by UV Irradiation Is Inhibited by Wortmannin without Affecting c-jun Expression

1999 • 60 citations

Platelet-derived Growth Factor-dependent Cellular Transformation Requires Either Phospholipase Cγ or Phosphatidylinositol 3 Kinase

1997 • 57 citations

Structural Determinants in the Platelet-derived Growth Factor α-Receptor Implicated in Modulation of Chemotaxis

1996 • 53 citations

Platelet-Derived Growth Factor Stimulation of Mitogen-Activated Protein Kinases and Cyclin D₁ Promoter Activity in Cultured Airway Smooth-Muscle Cells

1999 • 51 citations

The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with rasGAP.

1994 • 41 citations

Transforming Growth Factor- and Epidermal Growth Factor Activate Mitogen-Activated Protein Kinase and Its Substrates in Intestinal Epithelial Cells

1995 • 39 citations

Synergistic activation of JNK/SAPK by interleukin-1 and platelet-derived growth factor is independent of Rac and Cdc42

1999 • 33 citations

Platelet-derived growth factor (PDGF) B and A homodimers transform murine fibroblasts depending on the genetic background of the cell.

1994 • 24 citations

Biosynthesis and Processing of the Platelet Derived Growth Factor Type α Receptor

1993 • 15 citations

26 Platelet-derived growth factor-BB induces apoptosis in cultured vascular smooth muscle cells derived from human saphenous vein

1998 • 6 citations