Review The link between low-LET dose-response relations and the underlying kinetics of damage production/repair/misrepair

The linear-quadratic formula and progress in fractionated radiotherapy

1989 • 2,150 citations

Stochastic Simulation

1987 • 1,835 citations

International Journal of Radiation Biology

1959 • 1,730 citations

Chromosomal translocations in human cancer

1994 • 1,551 citations

Stochastic Simulation

1987 • 1,081 citations

The application of the linear-quadratic dose-effect equation to fractionated and protracted radiotherapy

1985 • 826 citations

Radiation-induced apoptosis: Relevance to radiotherapy

1995 • 504 citations

An ‘Incomplete-repair’ Model for Survival after Fractionated and Continuous Irradiations

1985 • 471 citations

Lethal and Potentially Lethal Lesions Induced by Radiation --- A Unified Repair Model

1986 • 469 citations

A Generalized Formulation of Dual Radiation Action

1978 • 367 citations

The Yield of DNA Double-strand Breaks Produced Intracellularly by Ionizing Radiation: A Review

1990 • 312 citations

Microdosimetry and Its Applications

1996 • 294 citations

Effects of Radiations of Different Qualities on Cells: Molecular Mechanisms of Damage and Repair

1993 • 286 citations

Characterization of the Adaptive Response to Ionizing Radiation Induced by Low Doses of X Rays to Human Lymphocytes

1987 • 273 citations

Constraints on Energy Deposition and Target Size of Multiply Damaged Sites Associated with DNA Double-strand Breaks

1992 • 271 citations

The Molecular Theory of Radiation Biology

1981 • 248 citations

A microdosimetric-kinetic model of cell death from exposure to ionizing radiation of any LET, with experimental and clinical applications

1996 • 211 citations

Review of repair kinetics for DNA damage induced in eukaryotic cells in vitro by ionizing radiation

1989 • 206 citations

Review: Proximity effects in the production of chromosome aberrations by ionizing radiation

1997 • 156 citations

DNA double-strand break distributions in X-ray and alpha-particle irradiated V79 cells: evidence for non-random breakage

1997 • 153 citations

Intrinsic radiosensitivity as a predictor of patient response to radiotherapy

1995 • 135 citations

A convenient extension of the linear-quadratic model to include redistribution and reoxygenation

1995 • 116 citations

Quantification of low-level radiation exposure by conventional chromosome aberration analysis

1995 • 108 citations

Fundamentals of microdosimetry

1985 • 106 citations

Ionizing Radiation Damage and Its Early Development in Chromosomes

1993 • 101 citations

Chromosome-exchange Aberrations in Human Lymphocytes

1967 • 92 citations

Fundamentals of Microdosimetry

1985 • 91 citations

Dose-response curves for simple and complex chromosome aberrations induced by X-rays and detected using fluorescence in situ hybridization

1996 • 88 citations

Relationship between the Recovery from Sublethal X-Ray Damage and the Rejoining of Chromosome Breaks in Normal Human Fibroblasts

1987 • 85 citations

Stochastik der Strahlenwirkung

1966 • 84 citations

Track Structure, Lesion Development, and Cell Survival

1990 • 79 citations

Relationship of Microdosimetric Techniques to Applications in Biological Systems

1987 • 77 citations

Programmed cell death and radioresistance

1996 • 76 citations

Statistical Interpretation of the Overdispersed Distribution of Radiation-Induced Dicentric Chromosome Aberrations at High LET

1981 • 73 citations

MOLECULAR LOCALIZATION OF RADIATION DAMAGE RELEVANT TO BACTERIAL INACTIVATION

1964 • 73 citations

Comparative Effects of Neutrons and X-Rays on Mammalian Cells

1963 • 72 citations

Fractionated high dose-rate versus low dose-rate regimens for intracavitary brachytherapy of the cervix: Equivalent regimens for combined brachytherapy and external irradiation

1991 • 68 citations

Chromosomal Abnormalities in Leukemia and Lymphoma: Clinical and Biological Significance

1986 • 59 citations

The ESTRO Breur lecture cellular sensitivity to low dose-rate irradiation focuses the problem of tumour radioresistance

1991 • 58 citations

What have we learnt from hyperbaric oxygen?

1991 • 55 citations

A Benchmark of Cell Survival Models Using Survival Curves for Human Cells after Completion of Repair of Potentially Lethal Damage

1994 • 48 citations

From targets to genes: a brief history of radiosensitivity

1996 • 46 citations

Induction and Repair of Chromosome Aberrations in scid Cells Measured by Premature Chromosome Condensation

1996 • 45 citations

Insight into sites

1996 • 44 citations

Comments on a time-dependent version of the linear-quadratic model

1990 • 44 citations

Rejoining and Misrejoining of Radiation-Induced Chromatin Breaks. I. Experiments with Human Lymphocytes

1996 • 44 citations

Kinetics of the Formation of Chromosome Aberrations in X-Irradiated Human Lymphocytes: Analysis by Premature Chromosome Condensation with Delayed Fusion

1995 • 44 citations

The Relationship between Radiosensitivity and Repair of Potentially Lethal Damage in Human Tumor Cell Lines with Implications for Radioresponsiveness

1990 • 42 citations

A Markov Formulation of the Repair-Misrepair Model of Cell Survival

1989 • 41 citations

Genetic alterations in leukemias and lymphomas: Impressive progress and continuing complexity

1997 • 40 citations

Chromosome Aberrations in Human Fibroblasts Induced by Monoenergetic Neutrons. I. Relative Biological Effectiveness

1996 • 40 citations

The Radiosensitivity of the Chromosomes of the Cells of Human Squamous Cell Carcinoma Cell Lines

1992 • 39 citations

Biologic Basis of Radiation Therapy

1997 • 37 citations

A New Model Describing the Curves for Repair of Both DNA Double-Strand Breaks and Chromosome Damage

1996 • 36 citations

Quantitative Mathematical Models in Radiation Biology

1988 • 36 citations

Biochemical aspects of radiation biology

1989 • 33 citations

Computer Simulation in Cell Radiobiology

1988 • 32 citations

On the mechanism of the formation of chromosomal aberrations by ionising radiation

1996 • 31 citations

Interpretation of inverse dose-rate effects for mutagenesis by sparsely ionizing radiation

1996 • 29 citations

The transmission of FISH-painted patterns derived from complex chromosome exchanges

1995 • 29 citations

DNA lesions and repair

1996 • 28 citations

Computational Approaches in Molecular Radiation Biology

1994 • 26 citations

Influence of time-dependent stochastic heterogeneity on the radiation response of a cell population

1994 • 25 citations

Effects of ?-particles on survial and chromosomal aberrations in human mammary epithelial cells

1995 • 25 citations

Resensitization due to Redistribution of Cells in the Phases of the Cell Cycle during Arbitrary Radiation Protocols

1996 • 24 citations

Proximity effects for chromosome aberrations measured by FISH

1996 • 24 citations

Repair rate in mouse lung after clinically relevant radiation doses per fraction.

1995 • 23 citations

Analysis of Deletions Induced in the Genome of Mammalian Cells by Ionizing Radiation

1995 • 22 citations

Modelling the kinetics of chromosome exchange formation in human cells exposed to ionising radiation

1996 • 21 citations

Evolution of DNA damage in irradiated cells

1992 • 21 citations

Two types of double-strand breaks in electron and photon tracks and their relation to exchange-type chromosome aberrations

1996 • 20 citations

The combined effects of sublethal damage repair, cellular repopulation and redistribution in the mitotic cycle. I. Survival probabilities after exposure to radiation.

1996 • 20 citations

A Simple Model of Radiation Action in Cells Based on a Repair Saturation Mechanism

1992 • 19 citations

Mechanisms of radiation-induced chromosome aberrations

1996 • 19 citations

Reaction Kinetics for the Development of Radiation-induced Chromosome Aberrations

1991 • 19 citations

Repair Rate in Mouse Lung after Clinically Relevant Radiation Doses per Fraction

1995 • 19 citations

Saturation in Dual Radiation Action

1988 • 16 citations

The pairwise lesion interaction model

1988 • 16 citations

The Lethal and Potentially Lethal Model — A Review and Recent Development

1988 • 15 citations

The Combined Effects of Sublethal Damage Repair, Cellular Repopulation and Redistribution in the Mitotic Cycle. I. Survival Probabilities after Exposure to Radiation

1996 • 15 citations

Comparison of six different models describing survival of mammalian cells after irradiation

1990 • 15 citations

Mechanisms of Induction of Specific Chromosomal Alterations

1990 • 13 citations

Implications of Delayed Reproductive Cell Death (Lethal Mutations/Genomic Instability) for the Interpretation of Tissue Responses

1995 • 12 citations

Model of mammalian cell reproductive death I. Basic assumptions and general equations

1993 • 9 citations

Problems, pitfalls, perspectives and potentials of quantitative theoretical models for cellular radiation action

1993 • 6 citations

Analyzing the Role of Biochemical Processes in Determining Response to Ionizing Radiations

1989 • 6 citations

Cell Recovery Kinetics for Split-dose, Multifractionated and Continuous Irradiation in the DSB Model

1993 • 6 citations

Radiobiological Cell Survival Models; A methodological overview

1992 • 5 citations

Generalised Microdosimetric Calculations of Cell-to-Cell Variance

1994 • 3 citations

A CYTOGENETIC MODEL OF RADIATION EFFECTS

1991 • 1 citations

Deleted Work

1955 • 0 citations