From targets to genes: a brief history of radiosensitivity

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

1953 • 12,496 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

ACTION OF X-RAYS ON MAMMALIAN CELLS

1956 • 1,660 citations

Cell population kinetics in the intestinal epithelium of the mouse

1959 • 1,446 citations

Actions of Radiations on Living Cells

1955 • 1,242 citations

Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity

1975 • 984 citations

Quantitation of Differential Sensitivity of Human-Tumor Stem Cells to Anticancer Drugs

1978 • 982 citations

THE ORGANIZATION AND DUPLICATION OF CHROMOSOMES AS REVEALED BY AUTORADIOGRAPHIC STUDIES USING TRITIUM-LABELED THYMIDINEE

1957 • 824 citations

Creative blocks: cell-cycle checkpoints and feedback controls

1992 • 686 citations

The theory of dual radiation action

1974 • 638 citations

Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy

1981 • 530 citations

The radioresponsiveness of human tumours and the initial slope ofthe cell survival curve

1984 • 472 citations

An ‘Incomplete-repair’ Model for Survival after Fractionated and Continuous Irradiations

1985 • 471 citations

Lethal and Potentially Lethal Lesions Induced by Radiation --- A Unified Repair Model

1986 • 469 citations

Biochemistry of DNA Lesions

1985 • 445 citations

Changes in X-ray Sensitivity of HeLa Cells during the Division Cycle

1961 • 440 citations

Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.

1990 • 403 citations

The mechanism of the induction by radiation of chromosome aberrations inTradescantia

1942 • 402 citations

Cell proliferation studies in the intestinal epithelium of the rat I. Determination of the kinetic parameters

1965 • 362 citations

X-ray-sensitive mutants of Chinese hamster ovary cell line isolation and cross-sensitivity to other DNA-damaging agents

1983 • 345 citations

The Yield of DNA Double-strand Breaks Produced Intracellularly by Ionizing Radiation: A Review

1990 • 312 citations

X-Ray and Ultraviolet Sensitivity of Synchronized Chinese Hamster Cells at Various Stages of the Cell Cycle

1965 • 304 citations

Radiation Dose-Rate: A Factor of Importance in Radiobiology and Radiotherapy

1972 • 303 citations

Nuclear incorporation of P as demonstrated by autoradiographs

1951 • 302 citations

Synthesis of Desoxyribonucleic Acid in Normal and Irradiated Cells and Its Relation to Chromosome Breakage

1986 • 301 citations

An in vitro colony assay for human tumours grown in immune-suppressed mice and treated in vivo with cytotoxic agents

1978 • 296 citations

The Four R's of Radiotherapy

1975 • 271 citations

The dose-rate effect in human tumour cells

1987 • 266 citations

Spatial and Temporal Distribution of Energy

1988 • 264 citations

The Molecular Theory of Radiation Biology

1981 • 248 citations

The 5Rs of Radiobiology

1989 • 240 citations

A Survival Curve for Mammalian Leukaemia Cells Irradiated 'in vivo (Implications for the Treatment of Mouse Leukaemia by Whole-Body Irradiation)

1959 • 218 citations

Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors.

1994 • 218 citations

Track Structure Analysis of Ultrasoft X-rays Compared to High- and Low-LET Radiations

1989 • 217 citations

X-Ray—Induced Breakage and Rejoining of Human Interphase Chromosomes

1983 • 197 citations

Intrinsic radiosensitivity and prediction of patient response to radiotherapy for carcinoma of the cervix

1993 • 186 citations

A DNA end-binding factor involved in double-strand break repair and V(D)J recombination.

1994 • 164 citations

The Repair-Misrepair Model in Radiobiology: Comparison to Other Models

1985 • 163 citations

Prediction of normal-tissue tolerance to radiotherapy from in-vitro cellular radiation sensitivity

1992 • 161 citations

Dose-Survival Curves of Human Cells in Tissue Culture Irradiated with Alpha-, Beta-, 20-KV. X- and 200-KV. X-Radiation

1962 • 155 citations

Dose Rate: Its Effect on the Survival of HeLa Cells Irradiated with Gamma Rays

1964 • 152 citations

Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations

1986 • 150 citations

Sublethal damage, potentially lethal damage, and chromosomal aberrations in mammalian cells exposed to ionizing radiations

1991 • 148 citations

Measurement of mutagenesis in mammalian cells.

1979 • 136 citations

Formation of large deletions by illegitimate recombination in the HPRT gene of primary human fibroblasts.

1993 • 135 citations

Dose-rate effects and the repair of radiation damage

1986 • 126 citations

Evidence for a Positive Correlation betweenin VitroRadiosensitivity of Normal Human Skin Fibroblasts and the Occurrence of Subcutaneous Fibrosis after Radiotherapy

1994 • 125 citations

Dose-rate effects in mammalian cells in culture III. Comparison of cell killing and cell proliferation during continuous irradiation for six different cell lines.

1979 • 123 citations

Impairment of the Proliferative Capacity of Human Cells in Culture by α-particles with Differing Linear-energy Transfer

1964 • 114 citations

Intrinsic radiosensitivity of normal human fibroblasts and lymphocytes after high- and low-dose-rate irradiation.

1992 • 114 citations

The search for therapeutic gain in the combination of radiotherapy and chemotherapy

1988 • 112 citations

Measurement of low levels of x-ray mutagenesis in relation to human disease.

1986 • 110 citations

The Kinetics of X-ray Survival of Mammalian Cellsin Vitro

1962 • 109 citations

Radiation-Induced Cellular Reproductive Death and Chromosome Aberrations

1978 • 107 citations

Types of chromosome structural change induced by the irradiation ofTradescantia microspores

1946 • 96 citations

The Rejoining of DNA Double-strand Breaks and a Model for the Formation of Chromosomal Rearrangements

1978 • 95 citations

Studies of the Dissemination and Quantitative Transplantation of a Lymphocytic Leukaemia of CBA Mice

1958 • 95 citations

Dose-Rate Effects in Mammalian Cells in Culture: III. Comparison of Cell Killing and Cell Proliferation during Continuous Irradiation for Six Different Cell Lines

1979 • 92 citations

Observations of Radiation-induced Chromosome Fragment Loss in Live Mammalian Cells in Culture, and Its Effect on Colony-forming Ability

1981 • 87 citations

Molecular genetic analysis of recessive mutations at a heterozygous autosomal locus in human cells

1990 • 83 citations

Track Structure, Lesion Development, and Cell Survival

1990 • 79 citations

Enhanced Post‐Irradiation Recovery of the Haemopoietic System In Animals Pretreated With A Variety of Cytotoxic Agents

1978 • 77 citations

The effect of ionization distribution on chromosome breakage by X-rays

1943 • 59 citations

The use of fluorescence in situ hybridisation combined with premature chromosome condensation for the identification of chromosome damage

1991 • 47 citations

Modification of the radiation response determined by single-cell technics: actinomycin D.

1959 • 43 citations

The Prevalence of Multilocus Lesions in Radiation-Induced Mutants

1994 • 40 citations

Ratios of radiation-produced chromosome aberrations as indicators of large-scale DNA geometry during interphase.

1993 • 40 citations

Lethal Mutations, the Survival Curve Shoulder and Split-dose Recovery

1989 • 33 citations

Genetics of growth arrest and cell death: Key determinants of tissue homeostasis

1994 • 21 citations

High colony‐forming efficiency of primary human tumor cells cultured in the adhesive‐tumor‐cell culture system: Improvements with medium and serum alterations

1988 • 20 citations

Ratios of Radiation-Produced Chromosome Aberrations as Indicators of Large-Scale DNA Geometry during Interphase

1993 • 20 citations

Experimental design considerations in clinically combining radiation and drugs

1979 • 6 citations

The collected papers of Douglas Lea

1966 • 4 citations

Dr. D. E. Lea

1947 • 1 citations