Activation of G-protein Gα subunits by receptors through Gα–Gβ and Gα–Gγ interactions

The Many Faces of G Protein Signaling

1998 • 1,137 citations

The 2.0 Å crystal structure of a heterotrimeric G protein

1996 • 1,118 citations

The structure of the G protein heterotrimer Giα1β1γ2

1995 • 1,091 citations

G PROTEIN MECHANISMS: Insights from Structural Analysis

1997 • 1,061 citations

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1994 • 823 citations

The 2.2 Å crystal structure of transducin-α complexed with GTPγS

1993 • 788 citations

Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis

1997 • 770 citations

The structural basis of the activation of Ras by Sos

1998 • 765 citations

Crystal structure of a GA protein βγdimer at 2.1 Å resolution

1996 • 741 citations

GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

1994 • 564 citations

How receptors talk to trimeric G proteins

1997 • 562 citations

Structural Basis for Activation of ARF GTPase

1998 • 534 citations

Molecular Basis for Interactions of G Protein βγ Subunits with Effectors

1998 • 440 citations

Selectivity in Signal Transduction Determined by γ Subunits of Heterotrimeric G Proteins

1993 • 393 citations

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

2000 • 356 citations

GEFs: structural basis for their activation of small GTP-binding proteins

1999 • 334 citations

Arf, Arl, Arp and Sar proteins: a family of GTP‐binding proteins with a structural device for ‘front–back’ communication

2002 • 316 citations

Crystal Structure of the Adenylyl Cyclase Activator G _{s α}

1997 • 310 citations

Tertiary and Quaternary Structural Changes in G _iα1 Induced by GTP Hydrolysis

1995 • 294 citations

The structure of the Escherichia coli EF-Tu· EF-Ts complex at 2.5 Å resolution

1996 • 289 citations

Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 Å

2001 • 260 citations

Structural determinants for GoLoco-induced inhibition of nucleotide release by Gα subunits

2002 • 243 citations

Structural Basis for Guanine Nucleotide Exchange on Ran by the Regulator of Chromosome Condensation (RCC1)

2001 • 231 citations

Receptor and βγ Binding Sites in the α Subunit of the Retinal G Protein Transducin

1997 • 196 citations

G-protein diseases furnish a model for the turn-on switch

1998 • 192 citations

Structural Basis for Nucleotide Exchange and Competition with tRNA in the Yeast Elongation Factor Complex eEF1A:eEF1Bα

2000 • 175 citations

Chapter 5 Interactions between photoexcited rhodopsin and light-activated enzymes in rods

1984 • 174 citations

Separate GTP Binding and GTPase Activating Domains of a Gα Subunit

1993 • 172 citations

The GoLoco motif: a Gαi/o binding motif and potential guanine-nucleotide exchange factor

1999 • 163 citations

Potent Peptide Analogues of a G Protein Receptor-binding Region Obtained with a Combinatorial Library

1996 • 152 citations

Light-activated rhodopsin induces structural binding motif in G protein α subunit

1998 • 149 citations

Crystal Structure of Intact Elongation Factor EF-Tu from Escherichia coli in GDP Conformation at 2.05Å Resolution

1999 • 134 citations

The transitory complex between photoexcited rhodopsin and transducin

1989 • 129 citations

Crystal structure of the EF-Tu˙EF-Ts complex from Thermus thermophilus

1997 • 122 citations

Specific interaction with rhodopsin is dependent on the gamma subunit type in a G protein.

1993 • 97 citations

Fatty Acylation of α2

1995 • 90 citations

Mutant G protein α subunit activated by Gβγ: A model for receptor activation?

2001 • 76 citations

Progress in retinal research

1987 • 76 citations

Rapid Activation of Transducin by Mutations Distant from the Nucleotide-binding Site

2001 • 66 citations

Selective Role of G Protein γ Subunits in Receptor Interaction

2000 • 49 citations

Disruption of the α5 Helix of Transducin Impairs Rhodopsin-Catalyzed Nucleotide Exchange

2002 • 49 citations

A Novel Site on the Gα-protein That Recognizes Heptahelical Receptors

2001 • 43 citations

Direct interaction of the alpha and gamma subunits of the G proteins. Purification and analysis by limited proteolysis.

1994 • 40 citations

G Protein γ Subunit Interaction with a Receptor Regulates Receptor-stimulated Nucleotide Exchange

2001 • 29 citations

Specificity of G Protein α- γ Subunit Interactions

1995 • 25 citations

Coupling between the N- and C-Terminal Domains Influences Transducin-α Intrinsic GDP/GTP Exchange

2000 • 18 citations

Mutagenesis in the switch IV of the helical domain of the human Gs? reduces its GDP/GTP exchange rate

2000 • 18 citations