The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site.

NMR with Proteins and Nucleic Acids

1986 • 7,896 citations

NMR of Proteins and Nucleic Acids

2006 • 5,989 citations

Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions

1992 • 3,627 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

Improved spectral resolution in COSY 1H NMR spectra of proteins via double quantum filtering

1983 • 2,327 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Overcoming the overlap problem in the assignment of proton NMR spectra of larger proteins by use of three-dimensional heteronuclear proton-nitrogen-15 Hartmann-Hahn-multiple quantum coherence and nuclear Overhauser-multiple quantum coherence spectroscopy: application to interleukin 1.beta.

1989 • 840 citations

Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester

1995 • 643 citations

The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue

1995 • 627 citations

Raf meets Ras: completing the framework of a signal transduction pathway

1994 • 591 citations

Lipid activation of protein kinase C.

1991 • 566 citations

The ins and outs of Raf kinases

1994 • 537 citations

Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence.

1989 • 439 citations

Extracellular signals and reversible protein phosphorylation: What to Mek of it all

1993 • 426 citations

Binding of 14-3-3 Proteins to the Protein Kinase Raf and Effects on Its Activation

1994 • 415 citations

Activation of Raf-1 by 14-3-3 proteins

1994 • 370 citations

Stimulatory Effects of Yeast and Mammalian 14-3-3 Proteins on the Raf Protein Kinase

1994 • 299 citations

Tautomeric states of the active‐site histidines of phosphorylated and unphosphorylated III^Glc, a signal‐transducing protein from escherichia coli, using two‐dimensional heteronuclear NMR techniques

1993 • 294 citations

Interaction of the Protein Kinase Raf-1 with 14-3-3 Proteins

1994 • 285 citations

EXAFS study of the zinc-binding sites in the protein transcription factor IIIA

1986 • 247 citations

Two Distinct Raf Domains Mediate Interaction with Ras

1995 • 243 citations

Definition of the human raf amino-terminal regulatory region by deletion mutagenesis.

1989 • 240 citations

Mutational Activation of c-raf-1 and Definition of the Minimal Transforming Sequence

1990 • 232 citations

The cysteine-rich region of raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras

1994 • 202 citations

Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues.

1994 • 175 citations

Complete resonance assignment for the polypeptide backbone of interleukin 1.beta. using three-dimensional heteronuclear NMR spectroscopy

1990 • 168 citations

Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins.

1995 • 165 citations

Nuclear magnetic resonance investigation of nitrogen-15-labeled histidine in aqueous solution

1977 • 165 citations

Cysteine-rich Region of Raf-1 Interacts with Activator Domain of Post-translationally Modified Ha-Ras

1995 • 157 citations

Residues in the Second Cysteine-rich Region of Protein Kinase C δ Relevant to Phorbol Ester Binding as Revealed by Site-directed Mutagenesis

1995 • 149 citations

Ras Interaction with Two Distinct Binding Domains in Raf-1 5 Be Required for Ras Transformation

1996 • 140 citations

Solution structure of a cysteine rich domain of rat protein kinase C

1994 • 131 citations

Purification, cDNA‐cloning and expression of human diacylglycerol kinase

1990 • 124 citations

Mechanism of activation of the vav protooncogene.

1991 • 122 citations

The cysteine-rich domain of human proteins, neuronal chimaerin, protein kinase C and diacylglycerol kinase binds zinc. Evidence for the involvement of a zinc-dependent structure in phorbol ester binding

1991 • 115 citations

Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila.

1993 • 110 citations

Solution Structure of the Ras-Binding Domain of c-Raf-1 and Identification of Its Ras Interaction Surface

1995 • 109 citations

Precise vicinal coupling constants3JHNα in proteins from nonlinear fits of J-modulated [15N,1H]-COSY experiments

1992 • 97 citations

Identification of the 14.3.3 ζ Domains Important for Self-association and Raf Binding

1995 • 93 citations

Peptides containing a consensus Ras binding sequence from Raf-1 and theGTPase activating protein NF1 inhibit Ras function.

1996 • 76 citations

Functional Mapping of the N-terminal Regulatory Domain in the Human Raf-1 Protein Kinase

1995 • 68 citations

Identification of discrete segments of human Raf-1 kinase critical for high affinity binding to Ha-Ras.

1994 • 55 citations

Definition of the Human raf Amino-Terminal Regulatory Region by Deletion Mutagenesis

1989 • 50 citations

Critical Binding and Regulatory Interactions between Ras and Raf Occur through a Small, Stable N-Terminal Domain of Raf and Specific Ras Effector Residues

1994 • 45 citations

Identification of a transforming activity suppressing sequence in the c-raf oncogene.

1988 • 30 citations

The N-terminal region of N-chimaerin allows lipid modulation of the C-terminal p21rac-GTPaseactivating domain

1992 • 3 citations