The NMDA Receptor Hypofunction Model of Psychosis

Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex

1997 • 1,743 citations

Glutamate Receptor Dysfunction and Schizophrenia

1995 • 1,682 citations

Neuregulin 1 and Susceptibility to Schizophrenia

2002 • 1,654 citations

Ketamine—Its Pharmacology and Therapeutic Uses

1982 • 1,490 citations

Ethanol-Induced Apoptotic Neurodegeneration and Fetal Alcohol Syndrome

2000 • 1,366 citations

Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs

1989 • 1,235 citations

Decrease in Reelin and Glutamic Acid Decarboxylase67 (GAD67) Expression in Schizophrenia and Bipolar Disorder

2000 • 1,189 citations

Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

1998 • 1,002 citations

Deficits in Small Interneurons in Prefrontal and Cingulate Cortices of Schizophrenic and Schizoaffective Patients

1991 • 889 citations

Genetic Variation in the 6p22.3 Gene DTNBP1, the Human Ortholog of the Mouse Dysbindin Gene, Is Associated with Schizophrenia

2002 • 842 citations

NMDA Antagonist Neurotoxicity: Mechanism and Prevention

1991 • 837 citations

Genetic and physiological data implicating the new human gene G72 and the gene for <scp>d</scp> -amino acid oxidase in schizophrenia

2002 • 828 citations

Ketamine: an update on the first twenty-five years of clinical experience

1989 • 714 citations

NMDA Receptor Function and Human Cognition: The Effects of Ketamine in Healthy Volunteers

1996 • 667 citations

Ketamine-Induced NMDA Receptor Hypofunction as a Model of Memory Impairment and Psychosis

1999 • 593 citations

NMDA-dependent modulation of CA1 local circuit inhibition

1996 • 481 citations

Attenuation of the Neuropsychiatric Effects of Ketamine With Lamotrigine

2000 • 418 citations

A subclass of prefrontal γ-aminobutyric acid axon terminals are selectively altered in schizophrenia

1998 • 408 citations

Corticolimbic Dopamine Neurotransmission Is Temporally Dissociated from the Cognitive and Locomotor Effects of Phencyclidine

1998 • 368 citations

Mental Illness in Adults With Fetal Alcohol Syndrome or Fetal Alcohol Effects

1998 • 357 citations

Interactive effects of subanesthetic ketamine and haloperidol in healthy humans

1999 • 237 citations

MK‐801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex

1991 • 233 citations

Enhancement of immobility in a forced swimming test by subacute or repeated treatment with phencyclidine: a new model of schizophrenia

1995 • 220 citations

Age-specific neurotoxicity in the rat associated with NMDA receptor blockade: Potential relevance to schizophrenia?

1995 • 215 citations

Clozapine Blunts N-Methyl-d-Aspartate Antagonist-Induced Psychosis: A Study with Ketamine

1997 • 197 citations

Dexmedetomidine Premedication Attenuates Ketamine-induced Cardiostimulatory Effects and Postanesthetic Delirium

1995 • 186 citations

Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans

1998 • 185 citations

NMDA receptor antagonists decrease GABA outflow from the septum and increase acetylcholine outflow from the hippocampus: a microdialysis study

1994 • 142 citations

Induction and suppression of immediate early genes in specific rat brain regions by the non-competitive N-methyl-d-aspartate receptor antagonist MK-801

1993 • 137 citations

Differential effects of clozapine and haloperidol on ketamine-induced brain metabolic activation

1998 • 127 citations

MK-801 induces c-fos protein in thalamic and neocortical neurons of rat brain

1990 • 126 citations

Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity

2002 • 121 citations

Metabolic mapping of the rat brain after subanesthetic doses of ketamine: potential relevance to schizophrenia

1998 • 118 citations

Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity

2002 • 116 citations

Multifocal brain damage induced by phencyclidine is augmented by pilocarpine

1997 • 109 citations

Haloperidol prevents induction of the hsp70 heat shock gene in neurons injured by phencyclidine (PCP), MK801, and ketamine

1992 • 106 citations

MK-801-induced neuronal damage in rats

1997 • 103 citations

Differential Effects of MK-801 on Brain-Derived Neurotrophic Factor mRNA Levels in Different Regions of the Rat Brain

1993 • 99 citations

Antipsychotic drugs block phencyclidine receptor-mediated neurotoxicity

1993 • 98 citations

Competitive and noncompetitive NMDA antagonists induce similar limbic degeneration

1994 • 95 citations

Phencyclidine induction of the hsp70 stress gene in injured pyramidal neurons is mediated via multiple receptors and voltage gated calcium channels

1994 • 89 citations

Excessive cerebrocortical release of acetylcholine induced by NMDA antagonists is reduced by GABAergic and α2-adrenergic agonists

1999 • 83 citations

Effects of phencyclidine on immediate early gene expression in the brain

1996 • 79 citations

Effects of MK-801 upon Local Cerebral Glucose Utilisation in Conscious Rats and in Rats Anaesthetised with Halothane

1989 • 76 citations

Ketamine-induced Changes in Regional Glucose Utilization in the Rat Brain

1980 • 72 citations

Localisation of phencyclidine-induced changes in brain energy metabolism

1979 • 71 citations

Serotonergic Agents That Activate 5HT2A Receptors Prevent NMDA Antagonist Neurotoxicity

1998 • 68 citations

MK801 induces immediate-early gene proteins and BDNF mRNA in rat cerebrocortical neurones

1993 • 65 citations

Halothane prevents MK-801 neurotoxicity in the rat cingulate cortex

1995 • 60 citations

Phencyclidine (PCP) and dizocilpine (MK801) exert time-dependent effects on the expression of immediate early genes in rat brain

1998 • 59 citations

MK-801 increases endogenous acetylcholine release in the rat parietal cortex: a study using brain microdialysis

1993 • 55 citations

Effects of oral clonidine premedication on side effects of intravenous ketamine anesthesia: a randomized, double-blind, placebo-controlled study

2000 • 49 citations

α2 Adrenergic Agonists Prevent MK-801 Neurotoxicity

1995 • 47 citations

DNQX inhibits phencyclidine (PCP) and ketamine induction of the hsp70 heat shock gene in the rat cingulate and retrosplenial cortex

1995 • 44 citations

Developmental changes in distribution patterns of phencyclidine-induced c-Fos in rat forebrain

1997 • 36 citations

Halothane and Diazepam Inhibit Ketamine-induced c-fos Expression in the Rat Cingulate Cortex

1996 • 31 citations

Can Schizophrenia Be Related to Prenatal Exposure to Alcohol? Some Speculations

1989 • 28 citations

Propofol Inhibits Ketamine-Induced c-fos Expression in the Rat Posterior Cingulate Cortex

1998 • 27 citations

Muscimol prevents NMDA antagonist neurotoxicity by activating GABAA receptors in several brain regions

2003 • 22 citations

Regionally different effects of scopolamine on NMDA antagonist-induced heat shock protein HSP70

1997 • 14 citations

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