Ketamine-Induced NMDA Receptor Hypofunction as a Model of Memory Impairment and Psychosis

The assessment and analysis of handedness: The Edinburgh inventory

1971 • 35,021 citations

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

The Pharmacological Basis of Therapeutics

1976 • 8,675 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

What are the functional consequences of neurocognitive deficits in schizophrenia?

1996 • 3,505 citations

Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans

1994 • 3,182 citations

A Standardized Memory Scale for Clinical Use

1945 • 2,925 citations

Recent advances in the phencyclidine model of schizophrenia

1991 • 2,886 citations

Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex

1989 • 2,677 citations

Wechsler Memory Scale-Revised

1987 • 2,327 citations

Negative Symptoms in Schizophrenia

1982 • 2,228 citations

Wechsler memory scale-revised

1988 • 2,058 citations

Diagnostic Interview for Genetic Studies

1994 • 2,004 citations

Memory and Brain

1987 • 1,821 citations

Stroop Color and Word Test: Manual for Clinical and Experimental Uses.

1978 • 1,788 citations

Glutamate Receptor Dysfunction and Schizophrenia

1995 • 1,682 citations

Ketamine—Its Pharmacology and Therapeutic Uses

1982 • 1,490 citations

Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs

1989 • 1,235 citations

Neuropsychological Function in Schizophrenia

1991 • 1,158 citations

Neuropsychological Deficits in Neuroleptic Naive Patients With First-Episode Schizophrenia

1994 • 1,099 citations

Study of a New Schizophrenomimetic Drug—Sernyl

1959 • 922 citations

Subanesthetic Doses of Ketamine Stimulate Psychosis in Schizophrenia

1995 • 891 citations

Some effects of frontal lobectomy in man

1964 • 852 citations

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit

1995 • 832 citations

Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D- aspartate receptor antagonist AP5

1989 • 766 citations

Ketamine: an update on the first twenty-five years of clinical experience

1989 • 714 citations

Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia

1980 • 703 citations

Ketamine-Induced Exacerbation of Psychotic Symptoms and Cognitive Impairment in Neuroleptic-Free Schizophrenics

1997 • 670 citations

NMDA Receptor Function and Human Cognition: The Effects of Ketamine in Healthy Volunteers

1996 • 667 citations

A multiple scoring method for the assessment of complex memory functions.

1975 • 625 citations

Determination of Free and Total Insulin and C-Peptide in Insulin-treated Diabetics

1977 • 593 citations

The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro

1992 • 545 citations

Memory improvement following induced hyperinsulinemia in alzheimer's disease

1996 • 495 citations

Memories of NMDA receptors and LTP

1995 • 484 citations

Abnormal Excitatory Neurotransmitter Metabolism in Schizophrenic Brains

1995 • 458 citations

Ketamine activates psychosis and alters limbic blood flow in schizophrenia

1995 • 438 citations

Glucocorticoid-induced impairment in declarative memory performance in adult humans

1994 • 437 citations

The neuropharmacological and neurochemical basis of place learning in the Morris water maze

1993 • 430 citations

Dissociative anesthesia: further pharmacologic studies and first clinical experience with the phencyclidine derivative CI-581.

1966 • 389 citations

Specific [3H]phencyclidine binding in rat central nervous system.

1979 • 382 citations

Medial temporal lesions in monkeys impair memory on a variety of tasks sensitive to human amnesia.

1985 • 366 citations

Impairments on Neuropsychologic Tests of Temporohippocampal and Frontohippocampal Functions and Word Fluency in Remitting Schizophrenia and Affective Disorders

1988 • 366 citations

Neuropsychological Functioning in Siblings Discordant for Schizophrenia and Healthy Volunteers

1994 • 355 citations

Medial temporal lesions in monkeys impair memory on a variety of tasks sensitive to human amnesia.

1985 • 353 citations

Psychometric Differentiation of Mild Senile Dementia of the Alzheimer Type

1984 • 322 citations

Some additional quantitative observations of immediate memory in a patient with bilateral hippocampal lesions

1968 • 314 citations

Facilitation of Working Memory in Humans by a D2 Dopamine Receptor Agonist

1992 • 276 citations

Effects of the NMDA antagonists CPP and MK-801 on radial arm maze performance in rats

1990 • 274 citations

A “Glutamatergic Hypothesis” of Schizophrenia

1989 • 270 citations

MODEL PSYCHOSES AND SCHIZOPHRENIA

1962 • 269 citations

Interaction of phencyclidine ("angel dust") with a specific receptor in rat brain membranes.

1979 • 263 citations

Human amnesia and animal models of amnesia: Performance of amnesic patients on tests designed for the monkey.

1988 • 259 citations

Hippocampal synaptic plasticity and NMDA receptors: a role in information storage?

1990 • 259 citations

Comparison of the Neuropsychological Deficits Associated With Early and Advanced Huntington's Disease

1978 • 240 citations

Human amnesia and animal models of amnesia: Performance of amnesic patients on tests designed for the monkey.

1988 • 225 citations

Intra-ventricular infusion of the NMDA antagonist AP5 impairs performance on a non-spatial operant DRL task in the rat

1988 • 225 citations

Learning impairment in rats by N-methyl-D-aspartate receptor antagonists

1988 • 222 citations

Intact verbal and nonverbal short‐term memory following damage to the human hippocampus

1992 • 222 citations

Ketamine

1985 • 193 citations

The Brief Psychiatric Rating Scale in Psychopharmacology Research

2015 • 187 citations

NMDA receptor antagonists can enhance or impair learning performance in animals

1989 • 184 citations

Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: A longitudinal study.

1993 • 179 citations

Memories of NMDA receptors and LTP

1995 • 176 citations

Plasma Cortisol Determination: Radioimmunoassay and Competitive Protein Binding Compared

1974 • 174 citations

Excitatory amino acid antagonists and memory: Effect of drugs acting at N-methyl-d-aspartate receptors in learning and memory tasks

1990 • 169 citations

Determination of free and total insulin and C-peptide in insulin-treated diabetics

1977 • 169 citations

Neuropsychological correlates of MRI temporal lobe abnormalities in schizophrenia

1993 • 166 citations

Effects of phencyclidine on excitatory amino acid activation of spinal interneurones in the cat

1982 • 162 citations

Observations on the psychotomimetic effects of sernyl

1961 • 159 citations

Evidence of glutamatergic deficiency in schizophrenia

1991 • 154 citations

Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: A longitudinal study.

1993 • 145 citations

Effects of interference on discrimination learning and recall by rats with hippocampal lesions

1979 • 142 citations

A novel NMDA antagonist, MK-801, impairs performance in a hippocampal-dependent spatial learning task

1989 • 141 citations

The animal model of human amnesia: long-term memory impaired and short-term memory intact.

1994 • 136 citations

The Behavioral Pharmacology of Phencyclidine

1976 • 129 citations

Comparison of Phencyclidine Hydrochloride (Sernyl) with Other Drugs

1962 • 128 citations

The Effect of 1-Arylcyclohexylamine (Sernyl) on Twelve Normal Volunteers

1960 • 125 citations

External and internal standards in the single-isotope derivative (radioenzymatic) measurement of plasma norepinephrine and epinephrine.

1985 • 122 citations

The performance of amnesic subjects on tests of experimental amnesia in animals: delayed matching-to-sample and concurrent learning

1988 • 120 citations

SERNYL (C1-395) IN CLINICAL ANAESTHESIA

1959 • 120 citations

N-methyl-D-aspartate antagonists and working memory performance: Comparison with the effects of scopolamine, propranolol, diazepam, and phenylisopropyladenosine.

1991 • 104 citations

Linear relationship between the maintenance of hippocampal long‐term potentiation and retention of an associative memory

1992 • 96 citations

MK-801 impedes the acquisition of a spatial memory task in rats

1990 • 92 citations

N-methyl-D-aspartate antagonists and working memory performance: Comparison with the effects of scopolamine, propranolol, diazepam, and phenylisopropyladenosine.

1991 • 85 citations

Glucose-Induced Increase in Memory Performance in Patients With Schizophrenia

1999 • 82 citations

Selective memory impairment by phencyclidine in rats

1987 • 77 citations

Effects of the novel NMDA antagonist, NPC 12626, on long-term potentiation, learning and memory

1991 • 62 citations

Acute behavioral effects of MK-801 in rhesus monkeys: Assessment using an operant test battery

1994 • 60 citations

The PCP Psychosis: Prolonged Intoxication or Drug-Precipitated Functional Illness?

1980 • 56 citations

Short-term and long-term memory in early temporal lobe dysfunction.

1998 • 54 citations

Short-term and long-term memory in early temporal lobe dysfunction.

1998 • 53 citations

Effects of phencyclidine, ketamine and MDMA on complex operant behavior in monkeys

1987 • 52 citations

Differential effects of σ and phencyclidine receptor ligands on learning

1990 • 45 citations

Reduction of cerebrospinal fluid glutamic acid in huntington's chorea and in schizophrenic patients

1980 • 45 citations

Acute phencyclidine (PCP) intoxication: psychopathology and prognosis.

1978 • 43 citations

Right-hippocampal contralateral-hand effect in the recall of spatial location in the tactual modality

1994 • 40 citations

Acute behavioral effects of phencyclidine on rhesus monkey performance in an operant test battery

1995 • 38 citations

ATTENTION, LEARNING, AND PERSONALITY DURING KETAMINE EMERGENCE

1976 • 33 citations

Effects of ketamine on adrenocortical function in man.

1970 • 33 citations

NMDA receptor channel antagonism by dizocilpine (MK-801) impairs performance of rats in aversively motivated complex maze tasks

1991 • 32 citations

Effects of hippocampal lesions on spatial delayed responses in dog

1995 • 25 citations

A multiple scoring method for the assessment of complex memory functions.

1975 • 25 citations

Phenycyclidine in combination with d-amphetamine: Differential effects on acquisition and performance of response chains in monkeys

1984 • 19 citations

Pituitary Adrenal Response to Ketamine and the Inhibition of the Response by Catecholaminergic Blockade

1974 • 16 citations

Hippocampal synaptic plasticity and NMDA receptors: a role in information storage?

1991 • 15 citations

Plasma Cortisol and blood sugar following minor surgery under intravenous anaesthetics

1974 • 13 citations

Serum free fatty acid and blood sugar levels in children under halothane, thiopentone and ketamine anaesthesia (comparative study)

1975 • 13 citations

Effects of Ketamine on Adrenocortical Function in Man

1970 • 12 citations

CLINICAL STUDIES OF INDUCTION AGENTS XXXVII: AMNESIC ACTION OF KETAMINE

1971 • 9 citations

Excitatory amino acid antagonists and memory: Effect of drugs acting at N- methyl-D-aspartate receptors in learning and memory tasks

1990 • 7 citations