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Minocycline Augmentation of Clozapine for Treatment Resistant Schizophrenia

NCT02533232

PHASE1INTERVENTIONAL
Pakistan Institute of Living and Learning
60 participants
Started 2022-08-30 · Completed 2022-12-30
Status: Unknown (as of 12-23-2025)

Conditions

SchizophreniaSchizoaffective DisorderSchizophreniform Disorder

Interventions

DRUG: Minocycline

Linked Papers (from SciSciNet-V2)

Total Papers15
Background
3
Result
0
Derived
0
Unknown
12
View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

This a randomized double-blind placebo controlled trial which aims to determine the beneficial effects of minocycline augmentation to clozapine in partial responders to Treatment Resistant Schizophrenia (TRS).

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Background Papers6

Minocycline, a Tetracycline Derivative, Is Neuroprotective against Excitotoxicity by Inhibiting Activation and Proliferation of Microglia
2001
919 citations
Minocycline, a Tetracycline Derivative, Is Neuroprotective against Excitotoxicity by Inhibiting Activation and Proliferation of Microglia
2001
919 citations
NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
2012
244 citations
NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
2012
244 citations
Pharmacological Augmentation Strategies for Schizophrenia Patients With Insufficient Response to Clozapine: A Quantitative Literature Review
2011
156 citations
Pharmacological Augmentation Strategies for Schizophrenia Patients With Insufficient Response to Clozapine: A Quantitative Literature Review
2011
156 citations

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers12

Recent advances in the phencyclidine model of schizophrenia
1991
2,886 citations
Size of burden of schizophrenia and psychotic disorders
2005
696 citations
Effectiveness of Second-Generation Antipsychotics in Patients With Treatment-Resistant Schizophrenia: A Review and Meta-Analysis of Randomized Trials
2001
631 citations
Microglia Activation in Recent-Onset Schizophrenia: A Quantitative (R)-[11C]PK11195 Positron Emission Tomography Study
2008
558 citations
Treatment-Resistant Schizophrenia - The Role of Clozapine
1997
463 citations
The inflammatory response system in treatment-resistant schizophrenia: increased serum interleukin-6
1998
317 citations
Glutamate and the Neural Basis of the Subjective Effects of Ketamine
2008
305 citations
Evaluation of Treatment-Resistant Schizophrenia
1997
241 citations
Neuroprotection by tetracyclines
2004
203 citations
The NMDA Receptor Hypofunction Model of Psychosis
2003
186 citations
The involvement of the NMDA receptor d-serine/glycine site in the pathophysiology and treatment of schizophrenia
2009
114 citations
Promising use of minocycline augmentation with clozapine in treatment-resistant schizophrenia
2014
22 citations