Phencyclidine (PCP) and dizocilpine (MK801) exert time-dependent effects on the expression of immediate early genes in rat brain

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1994 • 3,437 citations

Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun

1991 • 2,666 citations

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

Glutamate: A Neurotransmitter in Mammalian Brain

1984 • 1,981 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Glutamate Receptor Dysfunction and Schizophrenia

1995 • 1,682 citations

Physiological and pathophysiological roles of excitatory amino acids during central nervous system development

1990 • 1,427 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs

1989 • 1,235 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

Role of ion flux in the control of c-fos expression

1986 • 1,006 citations

Subanesthetic Doses of Ketamine Stimulate Psychosis in Schizophrenia

1995 • 891 citations

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.

1985 • 888 citations

NMDA Antagonist Neurotoxicity: Mechanism and Prevention

1991 • 837 citations

A gene activated by growth factors is related to the oncogene v-jun.

1988 • 771 citations

Stimulation of Neuronal Acetylcholine Receptors Induces Rapid Gene Transcription

1986 • 761 citations

Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: The “dormant basket cell” hypothesis and its possible relevance to temporal lobe epilepsy

1991 • 706 citations

Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro.

1987 • 630 citations

Common DNA binding site for Fos protein complexesand transcription factor AP-1

1988 • 613 citations

The Fos Complex and Fos-Related Antigens Recognize Sequence Elements That Co ntain AP-1 Binding Sites

1988 • 532 citations

Anatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sites

1983 • 522 citations

Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction.

1989 • 502 citations

Ketamine activates psychosis and alters limbic blood flow in schizophrenia

1995 • 438 citations

Schizophrenia and Glutamatergic Transmission

1998 • 385 citations

Convulsant-induced increase in transcription factor messenger RNAs in rat brain.

1988 • 377 citations

Fos: An immediate‐early transcription factor in neurons

1995 • 373 citations

Induction of the proto-oncogene fos by nerve growth factor.

1985 • 359 citations

Anatomic correlation of NMDA and 3H-TCP-labeled receptors in rat brain

1988 • 284 citations

Memories of fos

1987 • 253 citations

Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem

1990 • 246 citations

In primary cultures of cerebellar granule cells the activation of N-methyl-D-aspartate-sensitive glutamate receptors induces c-fos mRNA expression.

1989 • 236 citations

MK‐801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex

1991 • 233 citations

Modulation of Glutamate Receptors: Molecular Mechanisms and Functional Implications

1989 • 198 citations

Rapid Rise in Transcription Factor mRNAs in Rat Brain After Electroshock‐Induced Seizures

1990 • 188 citations

Allosteric modulation of amino acid receptors : therapeutic implications

1989 • 187 citations

Calcium as a modulator of the immediate-early gene cascade in neurons

1988 • 179 citations

Induction and suppression of immediate early genes in specific rat brain regions by the non-competitive N-methyl-d-aspartate receptor antagonist MK-801

1993 • 137 citations

Adrenergic receptors mediate changes in c-fos mRNA levels in brain

1989 • 126 citations

MK-801 induces c-fos protein in thalamic and neocortical neurons of rat brain

1990 • 126 citations

L-DOPA activates c-fos in the striatum ipsilateral to a 6-hydroxydopamine lesion of the substantia nigra

1989 • 121 citations

Differential induction of immediate early genes by excitatory amino acid receptor types in primary cultures of cortical and striatal neurons

1992 • 118 citations

Transcriptional program coordination by N-methyl-D-aspartate-sensitive glutamate receptor stimulation in primary cultures of cerebellar neurons.

1990 • 109 citations

Haloperidol prevents induction of the hsp70 heat shock gene in neurons injured by phencyclidine (PCP), MK801, and ketamine

1992 • 106 citations

Activation of specific glutamate receptor subtypes increases c-fos proto-oncogene expression in primary cultures of neonatal rat cerebellar granule cells

1987 • 100 citations

Synaptic Regulation of Immediate Early Gene Expression in Primary Cultures of Cortical Neurons

1991 • 90 citations

Glutamate receptors in the substantia nigra of Parkinson's disease brains

1992 • 83 citations

Excitotoxic neuronal damage and neuropsychiatric disorders

1993 • 80 citations

Effects of phencyclidine on immediate early gene expression in the brain

1996 • 79 citations

Origin of transmitters released by electrical stimulation from a small, metabolically very active vesicular pool of cholinergic synapses in guinea-pig cerebral cortex

1979 • 77 citations

Proto-oncogene c-fos induction in rat hippocampus

1988 • 71 citations

Alterations in local cerebral glucose utilization induced by phencyclidine

1987 • 68 citations

Delayed regional metabolic actions of phencyclidine

1993 • 67 citations

PCP‐induced alterations in cerebral glucose utilization in rat brain: Blockade by metaphit, a PCP‐receptor‐acylating agent

1987 • 50 citations

Nucleotide sequence of rat c-jun protooncogene

1990 • 48 citations

Regulation of Immediate Early Gene Expression

1993 • 39 citations

An increase in NMDA-sensitive [3H]glutamate and [3H]kainate binding in hippocampus 24 hours after PCP

1994 • 26 citations

MK801 induces late regional increases in NMDA and kainate receptor binding in rat brain

1995 • 25 citations

Phencyclidine produces changes in NMDA and kainate receptor binding in rat hippocampus over a 48-hour time course

1996 • 18 citations