Vaccination against the Intracellular PathogensLeishmania majorandL. amazonensisby Directing CD40 Ligand to Macrophages

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

Human Leishmaniasis: Clinical, Diagnostic, and Chemotherapeutic Developments in the Last 10 Years

1997 • 804 citations

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

1993 • 792 citations

The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major

1994 • 687 citations

IL-12: Initiation Cytokine for Cell-Mediated Immunity

1993 • 583 citations

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

1995 • 476 citations

Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies

1995 • 473 citations

IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis.

1995 • 427 citations

Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

1996 • 425 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies.

1981 • 386 citations

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.

1994 • 365 citations

Selective Suppression of Interleukin-12 Induction after Macrophage Receptor Ligation

1997 • 363 citations

Expression Cloning of a Protective Leishmania Antigen

1995 • 351 citations

CD40 Ligand Is Required for Protective Cell-Mediated Immunity to Leishmania major

1996 • 332 citations

Reversal of Proinflammatory Responses by Ligating the Macrophage Fcγ Receptor Type I

1998 • 330 citations

Constructing polycompetitor cDNAs for quantitative PCR

1993 • 323 citations

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.

1996 • 319 citations

Disruption of CD40–CD40 Ligand Interactions Results in an Enhanced Susceptibility to Leishmania amazonensis Infection

1996 • 311 citations

Role of the Leishmania surface protease gp63 in complement fixation, cell adhesion, and resistance to complement-mediated lysis.

1995 • 309 citations

CD40 ligand and its role in X-linked hyper-IgM syndrome

1993 • 257 citations

Effective immunization against cutaneous leishmaniasis with recombinant bacille Calmette-Guérin expressing the Leishmania surface proteinase gp63.

1993 • 218 citations

Functions of CD40 and Its Ligand, gp39 (CD40L)

2017 • 212 citations

Induction of IL-12 p40 messenger RNA expression and IL-12 production of macrophages via CD40-CD40 ligand interaction.

1996 • 197 citations

Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice.

1995 • 162 citations

CD40 Ligand/Trimer DNA Enhances Both Humoral and Cellular Immune Responses and Induces Protective Immunity to Infectious and Tumor Challenge

1998 • 159 citations

MOLECULAR DETERMINANTS OF LEISHMANIA VIRULENCE

1990 • 159 citations

Interleukin‐12 Production by Dendritic Cells

1996 • 155 citations

Functions of CD40 and Its Ligand, gp39 (CD40L)

1996 • 126 citations

The role of the innate immune response in Th1 cell development following Leishmania major infection

1995 • 123 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies. III. Validity tests for the single-hit Poisson model

1984 • 121 citations

Interaction ofLeishmaniagp63 with Cellular Receptors for Fibronectin

1999 • 116 citations

A common major surface antigen on amastigotes and promastigotes of Leishmania species.

1985 • 114 citations

Leishmania promastigotes require opsonic complement to bind to the human leukocyte integrin Mac-1 (CD11b/CD18).

1992 • 104 citations

Surface antigens of Leishmania donovani promastigotes.

1983 • 96 citations

IL-12 as an adjuvant for cell-mediated immunity

1997 • 84 citations

The induction of a protective response inLeishmania major-infected BALB/c mice with anti-CD40 mAb

1998 • 76 citations

Metacyclogenesis modulates the ability of Leishmania promastigotes to induce IL-12 production in human mononuclear cells.

1997 • 68 citations

Analysis of the active site and activation mechanism of the Leishmania surface metalloproteinase GP63

1995 • 50 citations

Leishmania amazonensis:The Phagocytosis of Amastigotes by Macrophages

1998 • 48 citations

Progressive disease or protective immunity to Leishmania major infection: the result of a network of stimulatory and inhibitory interactions

1998 • 47 citations

The regulation of IL-12: Its role in infectious, autoimmune, and allergic diseases

1998 • 43 citations

Genetic control of the immune response in mice to Leishmania mexicana surface protease.

1991 • 23 citations