Ovarian normal and tumor-associated fibroblasts retain in vivo stromal characteristics in a 3-D matrix-dependent manner

Cancer Statistics, 2007

2007 • 7,372 citations

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

2003 • 4,433 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Fibroblasts in cancer

2006 • 4,177 citations

Tensional homeostasis and the malignant phenotype

2005 • 3,655 citations

Taking Cell-Matrix Adhesions to the Third Dimension

2001 • 2,940 citations

Focal adhesion kinase: in command and control of cell motility

2005 • 2,405 citations

The microenvironment of the tumour–host interface

2001 • 2,307 citations

Stromal fibroblasts in cancer initiation and progression

2004 • 2,230 citations

Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors

2005 • 2,212 citations

Putting tumours in context

2001 • 2,145 citations

Friends or foes — bipolar effects of the tumour stroma in cancer

2004 • 1,742 citations

Modeling Tissue Morphogenesis and Cancer in 3D

2007 • 1,672 citations

The myofibroblast in wound healing and fibrocontractive diseases

2003 • 1,548 citations

Formation and Function of the Myofibroblast during Tissue Repair

2007 • 1,508 citations

Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium

2000 • 1,445 citations

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

2004 • 1,346 citations

Cell interactions with three-dimensional matrices

2002 • 874 citations

Engineering tumors with 3D scaffolds

2007 • 796 citations

The tumour microenvironment as a target for chemoprevention

2007 • 790 citations

Reconstruction of functionally normal and malignant human breast tissues in mice

2004 • 777 citations

Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling.

2002 • 750 citations

The pancreatic stellate cell: a star on the rise in pancreatic diseases

2007 • 649 citations

Tumor microenvironment: The role of the tumor stroma in cancer

2007 • 597 citations

The stroma reaction myofibroblast: a key player in the control of tumor cell behavior

2004 • 543 citations

ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix

2003 • 510 citations

The matrix reorganized: extracellular matrix remodeling and integrin signaling

2006 • 504 citations

REACTIVE STROMA IN PROSTATE CANCER PROGRESSION

2001 • 489 citations

Determination of cellular shape by the extracellular matrix and its correlation with the control of cellular growth.

1978 • 487 citations

Biomimetic amplification of nanoparticle homing to tumors

2007 • 457 citations

Tumor–stroma interactions

2004 • 444 citations

A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer.

2003 • 404 citations

The stroma as a crucial target in rat mammary gland carcinogenesis

2004 • 402 citations

Mechanisms of force generation and transmission by myofibroblasts

2003 • 399 citations

Mechanobiology in the Third Dimension

2005 • 383 citations

MOLECULAR INSIGHTS INTO PROSTATE CANCER PROGRESSION: THE MISSING LINK OF TUMOR MICROENVIRONMENT

2005 • 358 citations

Tumor reversion: Correction of malignant behavior by microenvironmental cues

2003 • 321 citations

Focus on epithelial ovarian cancer

2004 • 301 citations

Modulation of Fibroblast Morphology and Adhesion during Collagen Matrix Remodeling

2002 • 247 citations

Preparation of Extracellular Matrices Produced by Cultured and Primary Fibroblasts

2016 • 243 citations

The oncofetal domain of fibronectin defined by monoclonal antibody FDC-6: its presence in fibronectins from fetal and tumor tissues and its absence in those from normal adult tissues and plasma.

1985 • 242 citations

Fibronectin as target for tumor therapy

2005 • 237 citations

Stroma-Derived Three-Dimensional Matrices Are Necessary and Sufficient to Promote Desmoplastic Differentiation of Normal Fibroblasts

2005 • 233 citations

Stromagenesis: The changing face of fibroblastic microenvironments during tumor progression

2005 • 216 citations

Dimensions and dynamics in integrin function

2003 • 192 citations

Melanoma development and progression: a conspiracy between tumor and host

2002 • 190 citations

Function and regulation of melanoma–stromal fibroblast interactions: when seeds meet soil

2003 • 176 citations

Tumor-associated fibroblasts (part I): Active stromal participants in tumor development and progression?

2002 • 163 citations

Increased Expression of Integrin αvβ5 Induces the Myofibroblastic Differentiation of Dermal Fibroblasts

2006 • 161 citations

Emergentism as a default: Cancer as a problem of tissue organization

2005 • 149 citations

Microtubule function in fibroblast spreading is modulated according to the tension state of cell–matrix interactions

2007 • 145 citations

Prostate tumor-stroma interaction: molecular mechanisms and opportunities for therapeutic targeting

2002 • 134 citations

Genomic analysis of smooth muscle cells in three‐dimensional collagen matrix

2002 • 133 citations

Tumor-associated fibroblasts (part II): Functional impact on tumor tissue.

2002 • 124 citations

Stromagenesis During Tumorigenesis: Characterization of Tumor-associated Fibroblasts and Stroma-derived 3D Matrices

2009 • 111 citations

Nested collagen matrices: A new model to study migration of human fibroblast populations in three dimensions

2005 • 104 citations

The Molecular Basis of Pancreatic Fibrosis

2004 • 97 citations

FAK‐dependent regulation of myofibroblast differentiation

2006 • 95 citations

Cell–Matrix Entanglement and Mechanical Anchorage of Fibroblasts in Three-dimensional Collagen Matrices

2005 • 94 citations

Clinicopathological Significance of Stromal Myofibroblasts in Invasive Ductal Carcinoma of the Breast

2004 • 93 citations

Tenascin‐C upregulates matrix metalloproteinase‐9 in breast cancer cells: Direct and synergistic effects with transforming growth factor β1

2003 • 92 citations

Paradoxes in carcinogenesis: New opportunities for research directions

2007 • 84 citations

Modulation of prostate cancer growth in bone microenvironments

2003 • 73 citations

Highly Proliferative Fibroblasts Forming Fibrotic Focus Govern Metastasis of Invasive Ductal Carcinoma of the Breast

2001 • 71 citations

Tumors and their microenvironments: tilling the soil. Commentary re: A. M. Scott et al., A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin. Cancer Res., 9: 1639-1647, 2003.

2003 • 69 citations

Constitutive Phosphorylation of Focal Adhesion Kinase Is Involved in the Myofibroblast Differentiation of Scleroderma Fibroblasts

2005 • 68 citations

Desmoplastic breast carcinoma as a source of human myofibroblasts.

1984 • 68 citations

Distribution of oncofetal fibronectin in human mammary tumors: immunofluorescence study on histological sections.

1990 • 67 citations

Stromal-epithelial interactions in the progression of ovarian cancer: influence and source of tumor stromal cells

2001 • 64 citations

Binding of TGF-β1 latency-associated peptide (LAP) to αvβ6 integrin modulates behaviour of squamous carcinoma cells

2002 • 63 citations

Morphology, cytoskeletal organization, and myosin dynamics of mouse embryonic fibroblasts cultured on nanofibrillar surfaces

2007 • 56 citations

Human antibody derivatives against the fibroblast activation protein for tumor stroma targeting of carcinomas

2001 • 52 citations

Tissue homeostasis and the control of the neoplastic phenotype in epithelial cancers

2004 • 51 citations

Identification of oncofetal fibronectin in patients with advanced epithelial ovarian cancer

1998 • 44 citations

Recurrent neural networks can be trained to be maximum a posteriori probability classifiers

1995 • 43 citations

Novel antitenascin antibody with increased tumour localisation for Pretargeted Antibody-Guided RadioImmunoTherapy (PAGRIT)

2003 • 42 citations

Modelling molecular mechanisms of breast cancer and invasion: lessons from the normal gland

2007 • 41 citations

Three-dimensional Culture Regulates Raf-1 Expression to Modulate Fibronectin Matrix Assembly

2006 • 30 citations

Regulation of cell growth and the expression of extracellular matrix proteins in colorectal adenocarcinoma: a fibroblast-tumor cell coculture model to study tumor-host interactions in vitro

2003 • 27 citations

Over‐expression of tenascin‐C in malignant pleural mesothelioma

2003 • 25 citations

Markers for the development of early prostate cancer

2003 • 21 citations

6 Markers for the development of early prostate cancer

2002 • 2 citations