Down syndrome, Alzheimer's disease and the trisomy 16 mouse

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1983 • 3,028 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

1985 • 1,125 citations

The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome.

1973 • 340 citations

Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and down's syndrome

1983 • 250 citations

The neurobiologie consequences of down syndrome

1986 • 249 citations

Systematic approach to the study of trisomy in the mouse. II

1975 • 210 citations

Abnormalities of the nucleus basalis in Down's syndrome

1985 • 199 citations

Relationship between plaques, tangles, and dementia in Down syndrome

1980 • 189 citations

NON-CHOLINERGIC NEUROTRANSMITTER ABNORMALITIES IN ALZHEIMER'S DISEASE

1986 • 188 citations

Genetic basis for a mouse model of down syndrome

1986 • 93 citations

Autosomal aneuploidy in mice: Generation and developmental consequences

1986 • 90 citations

Familial aggregation in Alzheimer dementia—I. A model for the age-dependent expression of an autosomal dominant gene

1986 • 75 citations

Down's Syndrome in Adults: Brain Metabolism

1983 • 68 citations

The Neurobiology of Down syndrome

1986 • 68 citations

Thyrotropin-releasing hormone, luteinizing hormone-releasing hormone and substance P immuno-reactivity in post-mortem brain from cases of alzheimer-type dementia and Down's syndrome

1983 • 62 citations

Genetic mapping of <i>Prm-1, Igl-1, Smst, Mtv-6, Sod-1,</i> and <i>Ets-2</i>and localization of the Down syndrome region on mouse chromosome 16

1987 • 62 citations

Morphologic and neurochemical studies of embryonic brain development in murine trisomy 16

1984 • 60 citations

Neurochemical Changes in Murine Trisomy 16: Delay in Cholinergic and Catecholaminergic Systems

1984 • 47 citations

The mouse homolog of the human amyloid β protein (AD-AP) gene is located on the distal end of mouse chromosome 16: Further extension of the homology between human chromosome 21 and mouse chromosome 16

1987 • 44 citations

THE LOCUS ENCODING αA-CRYSTALLIN IS CLOSELY LINKED TO H-2K ON MOUSE CHROMOSOME 17

1985 • 43 citations

Mouse chimeras composed of trisomy 16 and normal (2n) cells: Preliminary studies

1986 • 32 citations

44 NUCLEUS BASALIS IN DOWNʼS SYNDROME

1984 • 7 citations