Aldose reductase: model for a new paradigm of enzymic perfection in detoxification catalysts

The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver

1967 • 1,821 citations

Binding Energy, Specificity, and Enzymic Catalysis: The Circe Effect

1975 • 844 citations

Evolution of enzyme function and the development of catalytic efficiency

1976 • 604 citations

The Aldo-Keto Reductase Superfamily

1989 • 455 citations

An Unlikely Sugar Substrate Site in the 1.65 Å Structure of the Human Aldose Reductase Holoenzyme Implicated in Diabetic Complications

1992 • 431 citations

The enzymes of detoxication.

1990 • 419 citations

Perfection in enzyme catalysis: the energetics of triosephosphate isomerase

1977 • 359 citations

REDUCTION OF α,γ-DIKETO AND α-KETO ACIDS CATALYZED BY MUSCLE PREPARATIONS AND BY CRYS-TALLINE LACTIC DEHYDROGENASE

1950 • 263 citations

Formaldehyde as a probe of DNA structure. I. Reaction with exocyclic amino groups of DNA bases

1975 • 228 citations

Catalysis, binding and enzyme-substrate complementarity

1974 • 222 citations

Novel NADPH-binding domain revealed by the crystal structure of aldose reductase

1992 • 193 citations

Aldose reductase and ϱ‐crystallin belong to the same protein superfamily as aldehyde reductase

1987 • 175 citations

LACTIC DEHYDROGENASE

1956 • 173 citations

An ABA and GA modulated gene expressed in the barley embryo encodes an aldose reductase related protein.

1991 • 165 citations

Equilibria for additions to the carbonyl group

1968 • 162 citations

SIGNIFICANCE OF SUBSTRATE INHIBITION OF DEHYDROGENASES*

1968 • 153 citations

Efficiency and Evolution of Enzyme Catalysis

1977 • 151 citations

Evolutionary optimization of the catalytic effectiveness of an enzyme

1989 • 145 citations

Kinetic and electrophoretic properties of native and recombined isoenzymes of human liver alcohol dehydrogenase

1983 • 141 citations

Amino Acid Composition and Properties of Crystalline Lactate Dehydrogenase X from Mouse Testes

1972 • 133 citations

Kinetic properties of human liver alcohol dehydrogenase: oxidation of alcohols by class I isoenzymes

1983 • 122 citations

The Mechanism of Enzyme-catalyzed Reduced Nicotinamide Adenine Dinucleotide-dependent Reductions

1972 • 114 citations

Properties of the testicular lactate dehydrogenase isoenzyme

1976 • 106 citations

Dissection of the catalytic mechanism of isozyme 4-4 of glutathione S-transferase with alternative substrates

1988 • 106 citations

Rate constants for a mechanism including intermediates in the interconversion of ternary complexes by horse liver alcohol dehydrogenase

1990 • 105 citations

Studies on pig muscle aldose reductase. Kinetic mechanism and evidence for a slow conformational change upon coenzyme binding.

1992 • 105 citations

On the origin of the lactate dehydrogenase induced rate effect

1984 • 103 citations

pH Variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase

1981 • 100 citations

PURIFICATION AND CHARACTERIZATION OF AN NADP ⁺ ‐LINKED ALCOHOL OXIDO‐REDUCTASE WHICH CATALYZES THE INTERCONVERSION OF γ‐HYDROXYBUTYRATE and SUCCINIC SEMIALDEHYDE¹

1979 • 69 citations

Mechanistic basis for nonlinear kinetics of aldehyde reduction catalyzed by aldose reductase

1990 • 68 citations

Designs for a broad substrate specificity keto acid dehydrogenase

1990 • 67 citations

Sequence analysis of bovine lens aldose reductase.

1990 • 66 citations

Production of methane in two non-ruminant herbivores

1978 • 64 citations

Kinetic and structural effects of activation of bovine kidney aldose reductase

1989 • 62 citations

Effect of evolution on the kinetic properties of enzymes

1989 • 61 citations

Human liver alcohol dehydrogenase isozymes: reduction of aldehydes and ketones

1984 • 59 citations

Specific and non‐specific succinic semialdehyde reductases from rat brain: Isolation and properties

1980 • 57 citations

Purification and properties of an NADP+-dependent glycerol dehydrogenase from rabbit skeletal muscle

1972 • 57 citations

Ring opening and closing rates for thiosugars

1979 • 47 citations

Tissue distribution of mammalian aldose reductase and related enzymes

1983 • 45 citations

Purification and steady-state kinetic characterization of human liver .beta.3.beta.3 alcohol dehydrogenase

1989 • 45 citations

Internal thermodynamics of enzymes determined by equilibrium quench: values of Kint for enolase and creatine kinase

1989 • 39 citations

Immunoquantitation of aldose reductase in human tissues

1989 • 39 citations

Aldehyde Oxidizing Enzymes

1980 • 37 citations

Mechanistic study of the addition of pyruvate to NAD⁺ catalyzed by lactate dehydrogenase

1978 • 34 citations

Purification and characterization of the multiple forms of aldehyde reductase in ox kidney

1982 • 32 citations

Pyruvate-induced inhibition in the dogfish lactate dehydrogenase system. Mechanistic comparison with the iodination of pyruvate

1974 • 29 citations

Purification and biochemical studies of lactate dehydrogenase-X from mouse

1977 • 26 citations

Bimodal substrate inhibition of lactate dehydrogenase. Factors affecting the enzyme in vivo

1978 • 25 citations

A study of the oxidation of butan-1-ol and propan-2-ol by nicotinamide-adenine dinucleotide catalysed by yeast alcohol dehydrogenase.

1975 • 25 citations

Lactate dehydrogenase catalyzed pyruvate adduct reaction: simulation general acid-base catalysis involving an enzyme and an external catalyst

1984 • 24 citations

Perfect enzymes: is the equilibrium constant between the enzyme's bound species unity?

1983 • 24 citations

Cross-linking of proteins by aldotriose: reaction of the carbonyl function of the keto amines generated in situ with amino groups

1988 • 22 citations

13C-NMR and transient kinetic studies on lactate dehydrogenase [Cys(13CN)165]. Direct measurement of a rate-limiting rearrangement in protein structure

1986 • 15 citations

Spectroscopic and kinetic characterization of nonenzymic and aldose reductase mediated covalent NADP-glycolaldehyde adduct formation

1990 • 14 citations

Phylogenetic conservation of epitopes in mammalian aldose reductase: Application to immunoquantitation

1986 • 11 citations

[49] Tartronic semialdehyde reductase (crystalline)

1966 • 6 citations

Enantiospecific change in products for aldose reductase-mediated reaction of glyceraldehyde with bound NADP+

1991 • 2 citations

[60] Propanediol dehydrogenase

1966 • 2 citations