Binding Energy, Specificity, and Enzymic Catalysis: The Circe Effect

Some Factors in the Interpretation of Protein Denaturation

1959 • 4,817 citations

Catalysis in chemistry and enzymology

1969 • 3,236 citations

Stereochemistry of Cooperative Effects in Haemoglobin: Haem–Haem Interaction and the Problem of Allostery

1970 • 2,874 citations

Application of a Theory of Enzyme Specificity to Protein Synthesis

1958 • 2,272 citations

The Structure and Properties of Water

1969 • 1,899 citations

Molecular Orbital Studies of Hydrogen Bonds. III. C=O···H–O Hydrogen Bond in H2CO···H2O and H2CO···2H2O

1971 • 1,791 citations

The Solubility of Amino Acids and Two Glycine Peptides in Aqueous Ethanol and Dioxane Solutions

1971 • 1,417 citations

Mechanism of adenosine triphosphate hydrolysis by actomyosin

1971 • 1,289 citations

Catalysis in micellar and macromolecular systems

1978 • 1,285 citations

Physical Organic Chemistry

1941 • 1,182 citations

Enthalpy–entropy compensation phenomena in water solutions of proteins and small molecules: A ubiquitous properly of water

1970 • 1,173 citations

Physics and Chemistry of the Organic Solid State.

1964 • 989 citations

Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate Effect

1971 • 980 citations

Protic-dipolar aprotic solvent effects on rates of bimolecular reactions

1969 • 937 citations

The interpretation of protein structures: Total volume, group volume distributions and packing density

1974 • 906 citations

Molecular Architecture and Biological Reactions

1946 • 835 citations

Ionic processes in solution

1953 • 835 citations

The Solubility of Amino Acids and Related Compounds in Aqueous Urea Solutions

1963 • 657 citations

Design of organic complexing agents Strategies towards properties

2005 • 640 citations

Further considerations on the thermodynamics of chemical equilibria and reaction rates

1936 • 635 citations

Metalloenzymes: the entatic nature of their active sites.

1968 • 625 citations

The Catalytic and Regulatory Properties of Enzymes

1968 • 603 citations

Analog approaches to the structure of the transition state in enzyme reactions

1972 • 599 citations

P1,P5-Di(adenosine-5′)pentaphosphate, a Potent Multisubstrate Inhibitor of Adenylate Kinase

1973 • 524 citations

THE HEN EGG-WHITE LYSOZYME MOLECULE

1967 • 505 citations

Enzymatic Catalysis and Transition-State Theory

1973 • 501 citations

General acid-base catalysis of complex reactions in water

1972 • 480 citations

Mechanism of Action of Proteolytic Enzymes

1965 • 473 citations

Conformation of Biopolymers

1967 • 463 citations

Structure of crystalline α-chymotrypsin

1968 • 435 citations

Aspartate Transcarbamylase

1971 • 422 citations

Specific Binding of 4-Amino Folic Acid Analogues by Folic Acid Reductase

1961 • 389 citations

Subtilisin. Stereochemical mechanism involving transition-state stabilization

1972 • 376 citations

Hydrogen Bonds between Model Peptide Groups in Solution

1962 • 370 citations

Enzyme Kinetics

1967 • 368 citations

Nature of Haem–Haem Interaction

1972 • 360 citations

Conformational energy estimates for statistically coiling polypeptide chains

1967 • 349 citations

The Binding of Oligosaccharides Containing N-Acetylglucosamine and N-Acetylmuramic Acid to Lysozyme

1967 • 347 citations

Structure of crystalline α-chymotrypsin

1970 • 344 citations

Mechanism of the aminolysis of acetate esters

1974 • 320 citations

Antibody affinity—III the role of multivalence

1972 • 318 citations

The Reversible Hydration of Carbonyl Compounds

1966 • 285 citations

Standard Gibbs Free Energy, Enthalpy, and Entropy Changes as a Function of pH and pMg for Several Reactions Involving Adenosine Phosphates

1969 • 273 citations

AVIDIN. 3. THE NATURE OF THE BIOTIN-BINDING SITE

1963 • 267 citations

Molecular motion and structure of aqueous mixtures with nonelectrolytes as studied by nuclear magnetic relaxation methods

1970 • 258 citations

Lactate Dehydrogenases: Structure and Function

1973 • 258 citations

Conformational equilibria in α- and δ-chymotrypsin

1972 • 250 citations

The reversibility of adenosine triphosphate cleavage by myosin

1973 • 249 citations

Binding of Xenon to Sperm Whale Myoglobin

1965 • 235 citations

Micellar Catalysis in Organic Reactions: Kinetic and Mechanistic Implications

1970 • 227 citations

Catalysis, binding and enzyme-substrate complementarity

1974 • 222 citations

A non-empirical study of the hydrogen bond between peptide units

1970 • 215 citations

The Effect of Geminal Substitution Ring Size and Rotamer Distribution on the Intramolecular Nucleophilic Catalysis of the Hydrolysis of Monophenyl Esters of Dibasic Acids and the Solvolysis of the Intermediate Anhydrides

1960 • 209 citations

Transition-state stabilization and enzymic catalysis. Kinetic and molecular orbital studies of the rearrangement of chorismate to prephenate

1973 • 198 citations

Binding of the by-product analog benzylsuccinic acid by carboxypeptidase A

1973 • 193 citations

Free Volumes and Free Rotation in Simple Liquids and Liquid Saturated Hydrocarbons

1954 • 191 citations

Interactions of urea and other polar compounds in water

1975 • 190 citations

Handbook of Biochemistry

2018 • 190 citations

Recognition of tRNA by isoleucyl-tRNA synthetase

1969 • 186 citations

The energetics of neighbouring group participation

1973 • 185 citations

Evidence for an Aspartyl Phosphate Residue at the Active Site of Sodium and Potassium Ion Transport Adenosine Triphosphatase

1973 • 183 citations

Use of peptide aldehydes to generate transition-state analogs of elastase

1973 • 181 citations

Substrate binding site in bovine chymotrypsin A_γ. Crystallographic study using peptide chloromethyl ketones as site-specific inhibitors

1971 • 181 citations

The Anatomy of an Enzymatic Catalysis. α-Chymotrypsin

1964 • 179 citations

Flip‐Flop Mechanisms in Enzymology

1971 • 174 citations

Aldehydes as Inhibitors of Papain

1972 • 169 citations

X-ray crystallographic study of the binding of peptide chloromethyl ketone inhibitors to subtilisin BPN

1972 • 168 citations

Equilibria for additions to the carbonyl group

1968 • 162 citations

Progress in Solid-State Chemistry

1974 • 162 citations

Relation between structure, co-operativity and spectra in a model of hemoglobin action

1973 • 160 citations

Organic Reactions Occurring in or on Micelles. I. Reaction Rate Studies of the Alkaline Fading of Triphenylmethane Dyes and Sulfonphthalein Indicators in the Presence of Detergent Salts¹

1959 • 159 citations

Thiol Addition to the Carbonyl Group. Equilibria and Kinetics¹

1966 • 157 citations

Stereopopulation control. I. Rate enhancement in the lactonizations of o-hydroxyhydrocinnamic acids

1972 • 156 citations

Crystal structure of a lysozyme-tetrasaccharide lactone complex

1974 • 155 citations

Concerted Displacement Reactions. VII. The Mechanism of Acid—Base Catalysis in Non-aqueous Solvents¹

1952 • 154 citations

A Source for the Special Catalytic Power of Enzymes: Orbital Steering

1970 • 153 citations

Equilibrium and rate constants for the interconversion of two conformations of α-chymotrypsin

1971 • 150 citations

On the nature of the protein interior

1971 • 149 citations

Camphor binding of Pseudomonas putida cytochrome P-450. Kinetics and thermodynamics of the reaction

1972 • 146 citations

The Mechanism of Enzyme Action

1954 • 146 citations

Entropies of Activation and Mechanisms of Reactions in Solution

1963 • 145 citations

Studies on the Mechanism of Action and the Structure of the Electrophilic Center of Histidine Ammonia Lyase

1969 • 144 citations

Hydrophobic nature of the active site of firefly luciferase

1969 • 136 citations

Mechanisms of thiamine-catalyzed reactions. Decarboxylation of 2-(1-carboxy-l-hydroxyethyl)-3,4-dimethylthiazolium chloride

1970 • 135 citations

Thermodynamics of micellization of N-alkyl betaines

1965 • 133 citations

EFFECTS OF MICELLIZATION ON THE KINETICS OF THE HYDROLYSIS OF MONOALKYL SULFATES

1962 • 132 citations

Rate Acceleration by Stereopopulation Control: Models for Enzyme Action

1970 • 132 citations

The entropy of solution

1938 • 131 citations

Molecular Orbital Studies of Hydrogen Bonds: Dimeric H2O with the Slater Minimal Basis Set

1970 • 131 citations

Subsite mapping of enzymes. Studies on Bacillus subtilis amylase

1970 • 127 citations

Micellar effects upon nucleophilic aromatic and aliphatic substitution

1968 • 126 citations

Induced Fit in Yeast Hexokinase

1970 • 125 citations

Studies on the Specificity of Pepsin^*

1967 • 125 citations

The effect of long-chain salts on indicators: the valence-type of indicators and the protein error

1934 • 125 citations

Leaving group specificity in the chymotrypsin-catalyzed hydrolysis of peptides. Stereochemical interpretation

1973 • 125 citations

THE HYDROPHOBIC CONTRIBUTION TO MICELLE FORMATION: THE SOLUBILITY OF ETHANE, PROPANE, BUTANE, AND PENTANE IN SODIUM DODECYL SULFATE SOLUTION¹

1963 • 122 citations

Transfer of amino acid from a transfer ribonucleic acid synthetase-aminoacyl adenylate complex to transfer ribonucleic acid

1972 • 122 citations

Substrate synergism and phosphoenzyme formation in catalysis by succinyl coenzyme A synthetase

1968 • 116 citations

Nonpolar contributions to the rate of nucleophilic displacements of p-nitrophenyl esters in micelles

1968 • 115 citations

Sodium-Potassium-activated Adenosine Triphosphatase

1969 • 114 citations

Neighboring Carbon and Hydrogen. XIV. Participation in Solvolysis of Some Primary Benzenesulfonates¹

1953 • 114 citations

The Reactivities of the Histidine Residues at the Active Site of Ribonuclease toward Halo Acids of Different Structures

1965 • 113 citations

Dependence of the kinetic parameters for elastase-catalyzed amide hydrolysis on the length of peptide substrates

1973 • 110 citations

Studies of the activity of chymotrypsin

1970 • 108 citations

Reporter group at the active site of acetoacetate decarboxylase. II. Ionization constant of the amino group

1971 • 108 citations

INTRAMOLECULAR MODELS DEPICTING THE KINETIC IMPORTANCE OF „FIT” IN ENZYMATIC CATALYSIS

1960 • 107 citations

The Hexokinases: Kinetic, Physical, and Regulatory Properties

1973 • 107 citations

Subsite Mapping of Enzymes

1971 • 106 citations

Thermodynamic group contributions from ion pair extraction equilibriums for use in the prediction of partition coefficients. Correlation of surface area with group contributions

1973 • 106 citations

1 The Hexokinases

1973 • 106 citations

Conformational Adaptability in Enzymes

1973 • 105 citations

Equilibria and Rates for Acetyl Transfer among Substituted Phenyl Acetates, Acetylimidazole, O-Acylhydroxamic Acids, and Thiol Esters

1964 • 104 citations

Catalytic Accelerations of 10 ¹² -Fold by an Enzyme-Like Synthetic Polymer

1972 • 104 citations

Kinetic specificity in papain-catalysed hydrolyses

1971 • 103 citations

The Active Site and Enzyme Action

1960 • 102 citations

Malic Dehydrogenase

1968 • 101 citations

ENZYMES OF FATTY ACID METABOLISM

1956 • 99 citations

The Compensation in ΔH[UNK] and ΔS[UNK] Accompanying the Conversion of Lower Order Nucleophilic Displacement Reactions to Higher Order Catalytic Processes. The Temperature Dependence of the Hydrazinolysis and Imidazole-Catalyzed Hydrolysis of Substituted Phenyl Acetates

1964 • 97 citations

Conditions for the self-catalysed inactivation of carnitine acetyltransferase. A novel form of enzyme inhibition

1969 • 96 citations

Specificity and stereospecificity of α-chymotrypsin

1967 • 94 citations

Mechanism of Hydrolysis of Adenosinetriphosphate by Muscle Proteins and Its Relation to Muscular Contraction

1959 • 94 citations

Indication of the magnitude of orientation factors in esterification

1972 • 93 citations

Kinetic Investigation of the α‐Chymotrypsin‐Catalyzed Hydrolysis of Peptide Substrates

1973 • 93 citations

The Reactivity of Nucleophilic Reagents with Furoyl-chymotrypsin

1965 • 92 citations

The specificity of enzymic reactions aminoacyl-soluble RNA ligases

1966 • 91 citations

Enzyme catalysis: Conflicting requirements of substrate access and transition state affinity

1974 • 91 citations

Mechanism of micellar effects on acylation of aryl oximes by p-nitrophenyl carboxylates

1971 • 90 citations

Adenosine Triphosphatase Activity of Yeast Hexokinase and Its Relation to the Mechanism of the Hexokinase Reaction

1965 • 89 citations

Brookhaven Symposium in Biology

1955 • 87 citations

Lactic Dehydrogenase

1967 • 86 citations

The Mechanism of Chymotrypsin-catalyzed Reactions. III

1959 • 86 citations

Pyridoxamine-Pyruvate Transaminase. II. Characteristics of the Enzyme^*

1963 • 85 citations

THERMODYNAMICS OF HYDROLYSIS OF PEPTIDE BONDS

1952 • 84 citations

Steric Course and Specificity of α-Chymotrypsin-catalyzed Reactions. II

1962 • 84 citations

Mechanism of Enzyme Catalysis

1964 • 81 citations

The crystal structure of hexam ethylenetetramine I. X -ray studies at 298, 100 and 34 °K

1963 • 81 citations

Implications of X-Ray Crystallographic Studies of Protein Structure

1968 • 80 citations

Mechanism of chymotrypsin. Structure, reactivity, and nonproductive binding relations

1973 • 80 citations

The comparison of non-enzymic and enzymic reaction velocities

1962 • 80 citations

PAPAIN-CATALYSED HYDROLYSIS OF SOME HIPPURIC ESTERS. A NEW MECHANISM FOR PAPAIN-CATALYSED HYDROLYSIS

1965 • 78 citations

Relative Strength of Picric, Acetic, and Trichloroacetic Acids in Various Environments. Dispersion Effects in Acid-Base Equilibria

1964 • 78 citations

THE STRUCTURE OF CARBOXYPEPTIDASE A, IX. THE X-RAY DIFFRACTION RESULTS IN THE LIGHT OF THE CHEMICAL SEQUENCE

1969 • 74 citations

Conformational changes in proteins as measured by difference sedimentation studies. II. Effect of stereospecific ligands on the catalytic subunit of aspartate transcarbamylase

1971 • 73 citations

Reactivity and Catalysis in Reactions of the Serine Hydroxyl Group and of O-Acyl Serines

1961 • 73 citations

Reporter group at the active site of acetoacetate decarboxylase. I. Ionization constant of the nitrophenol

1971 • 71 citations

105. The ionisation functions of di-isopropylcyanoacetic acid in relation to hydration equilibria and the compensation law

1965 • 71 citations

Micellar effects on kinetics and equilibrium of synthesis and hydrolysis of benzylideneaniline

1973 • 71 citations

Hydroxyl Group Catalysis. II. The Reactivity of the Hydroxyl Group of Serine. The Nucleophilicity of Alcohols and the Ease of Hydrolysis of Their Acetyl Esters as Related to Their pKa'^*

1962 • 70 citations

Intramolecular Carboxylate Attack on Ester Groups. The Hydrolysis of Substituted Phenyl Acid Succinates and Phenyl Acid Glutarates¹

1960 • 70 citations

A Transition State Analog for Lysozyme

1972 • 69 citations

Catalysis of ionic reactions by polyelectrolytes. Reaction of pentaamminechlorocobalt(III) ion and pentaamminebromocobalt(III) ion with mercuric ion in poly(sulfonic acid) solution

1969 • 68 citations

Secondary enzyme-substrate interactions and the specificity of pepsin

1970 • 67 citations

Molecular complexes and their spectra. XX. Gas-phase electron donor-acceptor complexes

1968 • 66 citations

Effect of ligand solvation on the stability of metal complexes in solution. Explanation of the macrocyclic effect

1974 • 65 citations

The Observation of Acyl-Enzyme Intermediates in the α-Chymotrypsin-Catalyzed Reactions of N-Acetyl-L-tryptophan Derivatives at Low pH

1964 • 65 citations

Comparison of the crystal structures of chymotrypsinogen-A and α-chymotrypsin

1973 • 64 citations

Decarboxylation of benzisoxazole-3-carboxylic acids. Catalysis by extraction of possible relevance to the problem of enzymic mechanism

1970 • 63 citations

CARBOXYPEPTIDASE A: APPROACHES TO THE CHEMICAL NATURE OF THE ACTIVE CENTER AND THE MECHANISMS OF ACTION

1963 • 63 citations

Theoretical Aspects of Orbital Steering

1971 • 63 citations

Solvation of ions. XVII. Free energies, heats, and entropies of transfer of single ions from protic to dipolar aprotic solvents

1973 • 62 citations

Conformational Changes in Aspartate Transcarbamylase

1972 • 60 citations

Cryptates: control over bivalent/monovalent cation selectivity

1973 • 59 citations

Molecular Theory of the Helix–Coil Transition in Polyamino Acids. III. Evaluation and Analysis of s and σ for Polyglycine and Poly-<scp>l</scp>-alanine in Water

1971 • 58 citations

The influence of ring size upon the stability of metal chelates

1954 • 57 citations

Molekül‐ und Gitterschwingungen des orthorhombischen und ferroelektrischen Thioharnstoffs: II. Berechnung der innermolekularen und zwischenmolekularen Kraftkonstanten

1971 • 56 citations

Relations between the energy and entropy of solution and their significance

1937 • 56 citations

pH dependencies of individual rate constants in papain-catalyzed reactions

1969 • 55 citations

Active site topography of isoleucyl transfer ribonucleic acid synthetase of Escherichia coli B

1973 • 54 citations

Direct and ¹⁸O-Exchange Measurements Relevant to Possible Activated or Phosphorylated States of Myosin^*

1966 • 54 citations

Secondary valence force catalysis. XII. Enhanced reactivity and affinity of cyanide ion toward N-substituted 3-carbamoylpyridinium ions elicited by ionic surfactants and biological lipids

1972 • 54 citations

Methotrexate Binding to Dihydrofolate Reductase from a Methotrexate-resistant Strain of Escherichia coli

1973 • 53 citations

Near Infrared Investigation of Interamide Hydrogen Bonding in Aqueous Solution

1964 • 52 citations

The reactivity of his-57 in chymotrypsin to alkylation

1971 • 52 citations

1 The Hydrolysis of Sulfate Esters

1971 • 52 citations

The Entatic State

1972 • 50 citations

Intramolecular Catalysis of Hydrolytic Reactions. IV. A Comparison of Intramolecular and Intermolecular Catalysis^1,2

1958 • 50 citations

Free energy of hydrolysis of the phosphoryl-enzyme intermediate in alkaline phosphatase-catalyzed reactions

1969 • 49 citations

Separation of a cyclic 3',5'-adenosine monophosphate binding protein from yeast

1972 • 48 citations

4 Proximity Effects and Enzyme Catalysis

1970 • 48 citations

The Kinetics of Yeast Hexokinase in the Light of the Induced Fit Involved in the Binding of its Sugar Substrate

1970 • 47 citations

Binding of peptides to elastase. Implications for the mechanism of substrate hydrolysis

1974 • 47 citations

The Structure of the Abortive Diphosphopyridine Nucleotide-Pyruvate-Lactate Dehydrogenase Ternary Complex as Determined by Proton Magnetic Resonance Analysis

1974 • 47 citations

Specificity of α-Chymotrypsin

1961 • 46 citations

Catalysis by reversed micelles in nonpolar solvents. Mutarotation of 2,3,4,6-tetramethyl-.alpha.-D-glucose in benzene and in cyclohexane

1972 • 46 citations

Specificity of the Valyl Ribonucleic Acid Synthetase from Escherichia coli in the Binding of Valine Analogues

1970 • 46 citations

Mechanism of Enzyme Inhibition by Phosphate Esters

1959 • 45 citations

Regulatory properties of adenosine triphosphate-<scp>l</scp>-methionine S-adenosyltransferase of rat liver

1973 • 45 citations

Free energies of hydrolysis of amides and peptides in aqueous solution at 25.deg.

1971 • 45 citations

Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Analysis of the phenylalanine binding site

1971 • 44 citations

Molekül‐ und Gitterschwingungen des orthorhombischen und ferroelektrischen Thioharnstoffs I. Temperaturabhängigkeit der Infrarot‐ und Ramanspektren und der berechneten Entropie

1971 • 44 citations

New model of liquid water

1972 • 44 citations

Solvation of ions. XVIII. Protic-dipolar aprotic solvent effects on the free energies, enthalpies, and entropies of activation of an SNAr reaction

1973 • 44 citations

Studies of protein and bound coenzyme fluorescence of lactate dehydrogenases

1964 • 44 citations

CONFORMATIONAL ENERGY CALCULATIONS OF ENZYME‐SUBSTRATE INTERACTIONS. II. Computation of the Binding Energy for Substrates in the Active Site of α‐Chymotrypsin

1972 • 43 citations

Dramatic rate enhancement of the aquation of the tris(oxalato)chromate(III) anion by surfactant solubilized water in benzene

1973 • 43 citations

Enzymatic Activities of Carboxypeptidase A's in Solution and in Crystals

1973 • 43 citations

Activation of Methionine for Transmethylation

1963 • 42 citations

Catalysis of ionic reactions by micelles. Reaction of chloropenteamminecobalt ion with mercury (II) ion in sodium alkyl sulfate solutions

1972 • 41 citations

4 N5-Methyltetrahydrofolate-Homocysteine Meihyltransferases

1973 • 41 citations

Über den Mechanismus der Wasserstoffübertragung mit Pyridinnucleotiden, XI Die nichtenzymatische Reduktion von Chinonen mit DPNH‐Modellen

1959 • 41 citations

Binding interactions between two ligands and a monomeric protein

1970 • 40 citations

Deuterium solvent isotope effects on reactions involving the aqueous hydroxide ion

1972 • 39 citations

Enhancement of micellar catalysis by added electrolytes

1971 • 38 citations

Protein densities from X-ray crystallographic coordinates

1974 • 37 citations

Thermodynamics and kinetics of the reactive site peptide-bond hydrolysis in bovine pancreatic secretory trypsin inhibitor (Kazal)

1973 • 37 citations

Nuclearmagnetic resonance studies of selectively hindered internal motion of substrate analogs at the active site of pyruvate kinase

1972 • 37 citations

Active Site of α-Chymotrypsin Activation by Association-Desolvation

1970 • 36 citations

Kinetics and mechanism of the morpholine-borane reduction of methyl alkyl ketones

1970 • 36 citations

“Orbital steering”, entropy, and rate accelerations

1974 • 35 citations

Ionization Behavior of the Histidine Residue in the Catalytic Triad of Serine Proteases

1973 • 35 citations

Mechanism of the Reaction Catalyzed by the Catalytic Subunit of Asparate Transcarbamylase. Kinetic Studies with Carbamyl Phosphate as Substrate

1973 • 35 citations

Benzoylamidoacetonitrile as an inhibitor of papain

1973 • 35 citations

Micellar Effects upon Aromatic Nucleophilic Substitution by Amines

1970 • 34 citations

Specificity of elastase. Hydrolysis of peptide p-nitrobenzyl esters

1972 • 33 citations

Acid anhydride-free acid equilibria in water in some substituted succinic acid systems and their interaction with aniline

1967 • 31 citations

11 Coenzyme A Transferases

1973 • 31 citations

KINETICS OF PAPAIN ACTION

1958 • 30 citations

Substrate specificity at the alkane binding sites of hemoglobin and myoglobin

1969 • 27 citations

Intramolecular general base catalysis in the aminolysis of acetylimidazole and methyl formate by diamines

1972 • 27 citations

Investigations of the Chymotrypsin-catalyzed Hydrolysis of Specific Substrates

1971 • 26 citations

The Free Energy of Hydrolysis of Acetic Anhydride¹

1966 • 25 citations

Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Analysis of the adenosine triphosphate binding site

1971 • 25 citations

Analysis of the binding of phenylalanine to phenylalanyl-tRNA synthetase

1973 • 25 citations

Vapor-phase charge-transfer complexes. VII. Iodine complexes with diethyl sulfide and dimethyl sulfide

1972 • 24 citations

The role of entropy and enthalpy factors in kinetic specificity of α-chymotrypsin

1972 • 24 citations

Biochemical aspects of the visual process

1970 • 23 citations

Catalysis by surfactant and phospholipid reversed micelles in nonpolar solvents. Decomposition of Meisenheimer complexes

1973 • 23 citations

ALTERNATING PATHS OF PHOSPHORYLATION OF THE SODIUM AND POTASSIUM ION PUMP OF PLASMA MEMBRANES

1973 • 23 citations

Solvation and approximation. Solvent effects on the bimolecular and intramolecular nucleophilic attack of carboxyl anion on phenyl esters

1970 • 23 citations

Effects of hydrophobic interaction on the kinetics of the reactions of long chain alkylamines with long chain carboxylic esters of 4-nitrophenol

1973 • 23 citations

The Entropy of Chelation

1956 • 22 citations

Electrolyte effects on bimolecular nucleophilic displacements

1968 • 22 citations

On the specificity of tryptic catalysis

1971 • 21 citations

Catalysis by reversed micelles in non-polar solvents: aquation and electron-transfer reactions of chromium(III) and cobalt(III) complexes in benzene

1974 • 21 citations

Substrate distortion in catalysis by lysozyme. Interaction of lysozyme with oligosaccharides containing N-acetylxylosamine

1972 • 20 citations

The contribution of proximity and orientation to catalytic reaction rates

1973 • 19 citations

Micellar effects upon phosphorylation and phosphate ester hydrolysis

1969 • 19 citations

Charge-Transfer Complex between Sulphur Dioxide and Trimethylamine in the Gas Phase and in Heptane

1967 • 19 citations

On the relationship between structure and reactivity of α‐chymotrypsin substrates

1971 • 19 citations

Substitution at saturated carbon. Part XII. Calculation of the electrostatic contribution to free energies of transfer from methanol to aqueous methanol and to water of solutes and transition states. A new method for the examination of transition states

1971 • 19 citations

The magnitude of enzyme transition state analog binding constants

1974 • 18 citations

Amine catalysis of .beta.-ketol dehydration. II. Catalysis via iminium ion formation. General analysis of nucleophilic amine catalysis

1973 • 18 citations

Equilibria in the Fibrinogen-Fibrin Conversion. V. Reversibility and Thermodynamics of the Proteolytic Action of Thrombin on Fibrinogen^1,2

1960 • 18 citations

A quantitative analysis of the binding of N-acyl derivatives of alpha-aminoamides by alpha-chymotrypsin.

1966 • 17 citations

The Time Dependence of the Activity of δ‐Chymotrypsin at High pH

1973 • 17 citations

Rate of ligand-promoted isomerization of proteins. Relaxation study of the “alkaline-transition” of δ-chymotrypsin

1971 • 17 citations

Neutral hydrolysis of p-nitrophenyl dichloroacetate in highly aqueous tert-butyl alcohol. Effects due to solvent structural integrity

1974 • 15 citations

Polar substituent effects and the ionization of acids

1971 • 15 citations

Chemical Specificity in Biological Interactions.

1955 • 14 citations

The Enzyme-Inhibitor Dissociation Constants of α-Chymotrypsin and Three Enantiomorphic Pairs of Competitive Inhibitors¹

1951 • 14 citations

Decarboxylation of Schiff bases

1973 • 13 citations

Mechanism of the reaction of phenylpropargylaldehyde with aqueous sodium hydroxide to give phenylacetylene and sodium formate

1971 • 13 citations

Deuterium solvent isotope effects in methanol solution. Part I. Fractionation factors for lyonium and lyate ions

1971 • 13 citations

Organic Reaction Mechanisms

1968 • 13 citations

A comparison of the utilization of methyl and p-nitrophenyl esters in determining the specificity of α-chymotrypsin

1972 • 13 citations

Entropy contributions to rate accelerations of intramolecular reactions in water VS non-structured solvents

1973 • 12 citations

Reactions in the gas and liquid phases: Comparison of kinetic and thermodynamic data

1973 • 11 citations

Kinetic Study of the Reaction Between Phosphine Imines and p-Nitrobenzaldehyde.

1972 • 10 citations

Thermodynamic and Kinetic Aspects of the Reaction of γ-Fluoroglutamate with d-Glutamate Cyclase

1971 • 9 citations

Change in rate-determining step for a simple carbonyl addition reaction. Kinetically significant proton transfer step in acid-catalyzed O-methyloxime formation

1973 • 9 citations

Inhibition of chymotrypsin A.alpha. with N-acyl- and N-peptidyl-2-phenylethylamines. Subsite binding free energies

1974 • 9 citations

The Effect of Hydroxylamine on the Kinetics of α-Chymotrypsin-catalyzed Reactions of Hippuric Acid Esters

1964 • 7 citations

710. Entropies of vaporization, and internal order in liquids

1950 • 7 citations

Activation parameters for semicarbazone formation

1967 • 7 citations

The Acylation of α-Chymotrypsin by N-Acetyl-L-tryptophan

1964 • 7 citations

Discrete effects of the acylamino proton in a chymotrypsin substrate on different processes in catalysis

1972 • 6 citations

The effect of lysozyme on some glycosides which contain N-acetylxylosamine residues

1974 • 2 citations

Bio-organic chemistry and mechanisms

1972 • 1 citations