Rate constants for a mechanism including intermediates in the interconversion of ternary complexes by horse liver alcohol dehydrogenase

[6] Statistical analysis of enzyme kinetic data

1979 • 2,002 citations

Analysis of numerical methods for computer simulation of kinetic processes: Development of KINSIM—A flexible, portable system

1983 • 597 citations

Studies on Liver Alcohol Dehydrogenase. I. Equilibria and Initial Reaction Velocities.

1951 • 446 citations

[29] Solvent isotope effects on enzyme systems

1982 • 394 citations

Structure of a triclinic ternary complex of horse liver alcohol dehydrogenase at 2.9 Å resolution

1981 • 373 citations

Binding of substrate in a ternary complex of horse liver alcohol dehydrogenase.

1982 • 255 citations

Product Inhibition Studies on Yeast and Liver Alcohol Dehydrogenases^*

1963 • 241 citations

Liver alcohol dehydrogenase.

1987 • 169 citations

Structures and isotopic fractionation factors of complexes, A1HA2-

1980 • 158 citations

Interdomain motion in liver alcohol dehydrogenase. Structural and energetic analysis of the hinge bending mode.

1986 • 156 citations

Mechanistic deductions from isotope effects in multireactant enzyme mechanisms

1981 • 142 citations

Structures and isotopic fractionation factors of complexes AHA-1

1977 • 133 citations

pH Variation of isotope effects in enzyme-catalyzed reactions. 1. Isotope- and pH-dependent steps the same

1981 • 118 citations

Equilibrium Reaction Rates and the Mechanisms of Liver and Yeast Alcohol Dehydrogenase

1964 • 110 citations

Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions

1980 • 107 citations

pH Variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase

1981 • 100 citations

Comparison of substrate specificity of alcohol dehydrogenases from human liver, horse liver, and yeast towards saturated and 2-enoic alcohols and aldehydes

1973 • 100 citations

Proton equilibriums and kinetics in the liver alcohol dehydrogenase reaction mechanism

1974 • 93 citations

Carboxyl groups near the active site zinc contribute to catalysis in yeast alcohol dehydrogenase.

1988 • 80 citations

Effect of pH on Coenzyme Binding to Liver Alcohol Dehydrogenase

1979 • 71 citations

Effect of pH on the Process of Ternary‐Complex Interconversion in the liver‐Alcohol‐Dehydrogenase Reaction

1978 • 71 citations

Transition structure for hydride transfer to pyridinium cation from methanolate. Modeling of LADH catalyzed reaction

1988 • 70 citations

Catalytic steps during the single-turnover reduction of aldehydes by alcohol dehydrogenase

1972 • 69 citations

Transition-state structure in the yeast alcohol dehydrogenase reaction: the magnitude of solvent and .alpha.-secondary hydrogen isotope effects

1980 • 64 citations

The Effects of pH and Temperature on Hydrogen Transfer in the Liver Alcohol Dehydrogenase Mechanism

1972 • 61 citations

Kinetics of native and activated isozymes of horse liver alcohol dehydrogenase

1977 • 58 citations

Effect of substrate structure on the rate of the catalytic step in the liver alcohol dehydrogenase mechanism

1971 • 57 citations

Horse Liver Alcohol Dehydrogenase

1973 • 56 citations

Variation of transition-state structure as a function of the nucleotide in reactions catalyzed by dehydrogenases. 1. Liver alcohol dehydrogenase with benzyl alcohol and yeast aldehyde dehydrogenase with benzaldehyde

1984 • 55 citations

Electronic substituent effects during the liver alcohol dehydrogenase catalyzed reduction of aromatic aldehydes

1974 • 53 citations

Mechanism of binding of horse liver alcohol dehydrogenase and nicotinamide adenine dinucleotide

1988 • 52 citations

Divalent cation binding to the high- and low-affinity sites on G-actin

1987 • 51 citations

Involvement of histidine residues in the activity of horse liver alcohol dehydrogenase

1983 • 50 citations

Activity of liver alcohol dehydrogenase with various substituents on the amino groups

1974 • 44 citations

Solvent deuterium isotope effect on the liver alcohol dehydrogenase reaction

1979 • 39 citations

Active-site cobalt(II)-substituted horse liver alcohol dehydrogenase: characterization of intermediates in the oxidation and reduction processes as a function of pH

1987 • 39 citations

The Reaction of Liver Alcohol Dehydrogenase with Reduced Diphosphopyridine Nucleotide

1967 • 36 citations

Kinetic Transients in the Reduction of Aldehydes Catalysed by Liver Alcohol Dehydrogenase

1976 • 35 citations

Evidence that hydride transfer precedes proton transfer in the liver alcohol dehydrogenase catalyzed reduction of trans-4-(N,N-dimethylamino)cinnamaldehyde

1980 • 34 citations

Active site cobalt(II)-substituted liver alcohol dehydrogenase: characterization of intermediates in the reduction of p-nitrobenzaldehyde by rapid-scanning UV-visible spectroscopy

1983 • 31 citations

Pressure relaxation studies of isomerisations of horse liver alcohol dehydrogenase linked to NAD⁺ binding

1977 • 30 citations

On calculation of rate and dissociation constants from kinetic constants for the Ordered Bi Bi mechanism of liver alcohol dehydrogenase

1973 • 29 citations

Kinetics and native and modified liver alcohol dehydrogenase with coenzyme analogs: isomerization of enzyme-nicotinamide adenine dinucleotide complex

1986 • 23 citations

Primary deuterium and tritium isotope effects upon V/K in the liver alcohol dehydrogenase reaction with ethanol

1981 • 23 citations

Reactivity of horse liver alcohol dehydrogenase with 3-methylcyclohexanols

1988 • 18 citations